Alexander L Nielsen
Affiliations: | University of Copenhagen, København, Denmark |
Area:
Medicinal ChemistryGoogle:
"Alexander L Nielsen"Mean distance: (not calculated yet)
Parents
Sign in to add mentorKim David Janda | grad student | 2020-2020 | Scripps Institute | |
(Visiting Graduate Student) | ||||
Christian A. Olsen | grad student | 2017-2021 | Copenhagen University |
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Publications
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Bolding JE, Nielsen AL, Jensen I, et al. (2023) Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide-Activated Sirtuin 7. Angewandte Chemie (International Ed. in English). e202314597 |
Lin L, Patel EN, Nielsen AL, et al. (2023) Transformation of a Metal Chelate into a "Catch and Anchor" Inhibitor of Botulinum A Protease. International Journal of Molecular Sciences. 24 |
Rajabi N, Hansen TN, Nielsen AL, et al. (2022) Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme. Angewandte Chemie (International Ed. in English). e202115805 |
Moreno-Yruela C, Zhang D, Wei W, et al. (2022) Class I histone deacetylases (HDAC1-3) are histone lysine delactylases. Science Advances. 8: eabi6696 |
Troelsen KS, Bæk M, Nielsen AL, et al. (2021) Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase. Rsc Chemical Biology. 2: 627-635 |
Nielsen AL, Rajabi N, Kudo N, et al. (2021) Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration. Rsc Chemical Biology. 2: 612-626 |
Turner LD, Nielsen AL, Lin L, et al. (2021) Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A Protease. Acs Medicinal Chemistry Letters. 12: 1318-1324 |
Turner LD, Nielsen AL, Lin L, et al. (2021) Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach. Rsc Medicinal Chemistry. 12: 960-969 |
Shirey RJ, Hart JR, Sridharan B, et al. (2021) Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay. Bioorganic & Medicinal Chemistry. 42: 116246 |
Turner LD, Nielsen AL, Lin L, et al. (2021) COVALENT INHIBITION OF BOTULINUM NEUROTOXIN A - EXPLORATION OF WARHEAD REACTIVITY AND FUNCTION USING A BIFUNCTIONAL APPROACH. Toxicon : Official Journal of the International Society On Toxinology. 190: S72-S73 |