Shailesh Natvarbhai Mistry

Affiliations: 
University of Nottingham, Nottingham, England, United Kingdom 
Area:
GPCRs, medicinal chemistry, allosteric ligands, chemical biology tools
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"Shailesh Mistry"
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Parents

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Stephen Hill grad student 2005-2008 Nottingham
Barrie Kellam grad student 2005-2008 Nottingham
Barrie Kellam post-doc 2008-2012 Nottingham
Peter Scammells post-doc 2012-2014 Monash University

Children

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Sunil Rajput grad student 2013-2019 Nottingham
Timothy Fyfe grad student 2015-2019 University of Nottingham/Monash University
Emanuel Sousa grad student 2015-2020 Nottingham
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Publications

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Casella BM, Farmer JP, Nesheva DN, et al. (2023) Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2. Journal of Medicinal Chemistry
Farmer JP, Mistry SN, Laughton CA, et al. (2022) Development of fluorescent peptide G protein-coupled receptor activation biosensors for NanoBRET characterization of intracellular allosteric modulators. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 36: e22576
Kok ZY, Stoddart LA, Mistry SJ, et al. (2022) Optimization of Peptide Linker-Based Fluorescent Ligands for the Histamine H Receptor. Journal of Medicinal Chemistry. 65: 8258-8288
Soukarieh F, Liu R, Romero M, et al. (2020) Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown . Frontiers in Chemistry. 8: 204
Mistry SN, Marchand P, Kellam B. (2019) 27th Annual GP2A Medicinal Chemistry Conference. Pharmaceuticals (Basel, Switzerland). 12
Fyfe TJ, Kellam B, Sykes DA, et al. (2019) Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D Receptor. Journal of Medicinal Chemistry
Fyfe TJ, Kellam B, Mistry SN, et al. (2019) Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D receptor. European Journal of Medicinal Chemistry. 168: 474-490
van der Westhuizen ET, Spathis A, Khajehali E, et al. (2018) Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M Muscarinic Acetylcholine Receptors. Molecular Pharmacology. 94: 770-783
Fyfe TJ, Zarzycka B, Lim HD, et al. (2018) A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor. Journal of Medicinal Chemistry
Baker JG, Gardiner SM, Woolard J, et al. (2017) Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology
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