Donald K Scott

Affiliations: 
Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Area:
Metabolic regulation of gene expression; beta cell biology
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"Donald Scott"
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Publications

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Katz LS, Brill G, Wang P, et al. (2023) Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes. Molecular Metabolism. 101848
Katz LS, Baumel-Alterzon S, Scott DK, et al. (2021) Adaptive and maladaptive roles for ChREBP in the liver and pancreatic islets. The Journal of Biological Chemistry. 100623
Ackeifi C, Wang P, Karakose E, et al. (2020) GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration. Science Translational Medicine. 12
Maachi H, Fergusson G, Ethier M, et al. (2019) HB-EGF Signaling is Required for Glucose-Induced Pancreatic β-cell Proliferation in Rats. Diabetes
Levasseur EM, Yamada K, Piñeros AR, et al. (2019) Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis. Science Signaling. 12
Rosselot C, Kumar A, Lakshmipathi J, et al. (2019) Myc Is Required for Adaptive ß-Cell Replication in Young Mice but Is not Sufficient in One-Year-Old Mice Fed with a High-Fat Diet. Diabetes
Baumel-Alterzon S, Katz LS, Brill G, et al. (2019) 2141-P: Nrf2 Mediates Glucose-Stimulated Beta-Cell Proliferation Diabetes. 68
Wang P, Karakose E, Liu H, et al. (2018) Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells. Cell Metabolism
Kumar A, Katz LS, Schulz AM, et al. (2018) Activation of Nrf2 is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation. Diabetes
Puri S, Roy N, Russ HA, et al. (2018) Replication confers β cell immaturity. Nature Communications. 9: 485
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