Lena Quambusch, Ph.D.
Affiliations: | 2017-2022 | Chemical Biology | TU Dortmund |
Area:
Chemical Biology, Stucture-Based Drug Design, Covalent-InhibitorsGoogle:
"Lena Quambusch"Mean distance: (not calculated yet)
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Publications
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| van der Westhuizen L, Weisner J, Taher A, et al. (2022) Covalent allosteric inhibitors of Akt generated using a click fragment approach. Chemmedchem |
| Quambusch L, Depta L, Landel I, et al. (2021) Cellular model system to dissect the isoform-selectivity of Akt inhibitors. Nature Communications. 12: 5297 |
| Landel I, Quambusch L, Depta L, et al. (2020) Spotlight on AKT: Current Therapeutic Challenges. Acs Medicinal Chemistry Letters. 11: 225-227 |
| Quambusch L, Landel I, Depta L, et al. (2019) Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity. Angewandte Chemie (International Ed. in English) |
| Uhlenbrock N, Smith S, Weisner J, et al. (2019) Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt. Chemical Science. 10: 3573-3585 |
| Weisner J, Landel I, Reintjes C, et al. (2019) Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-mutant Pancreatic and Colorectal Cancer. Cancer Research |
| Tesch R, Becker C, Müller MP, et al. (2018) An Unusual Intramolecular Halogen Bond guides Conformational Selection. Angewandte Chemie (International Ed. in English) |
| Rauh D, Bührmann M, Hardick J, et al. (2017) Covalent Lipid Pocket Ligands Targeting p38α MAPK Mutants. Angewandte Chemie (International Ed. in English) |