Aakash Saha, MS
Affiliations: | 2018- | Bioengineering | University of California, Riverside, Riverside, CA, United States |
Area:
Computational Chemistry, Biophysics, Computational Biology, Molecular Dynamics Simulations, Molecular Biology, Animal Cell CultureGoogle:
"Aakash Saha"Bio:
After earning my undergraduate degree in Biotechnology from India, I pursued my passion for research by entering into a doctoral program at University of California, Riverside. My current research is focused on understanding CRISPR-Cas systems using state-of-the-art computational tools, and multi-scale classical and enhanced molecular dynamics approaches. I intend to understand and ameliorate the functioning by providing the groundwork for protein engineering strategies for this intriguing system that has revolutionized genome-editing technology, and gives hope to millions of people for a better day for them and their loved ones.
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Publications
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Kumar A, Arantes PR, Saha A, et al. (2023) GPU-Enhanced DFTB Metadynamics for Efficiently Predicting Free Energies of Biochemical Systems. Molecules (Basel, Switzerland). 28 |
Pacesa M, Lin CH, Cléry A, et al. (2022) Structural basis for Cas9 off-target activity. Cell. 185: 4067-4081.e21 |
Rossetti M, Merlo R, Bagheri N, et al. (2022) Enhancement of CRISPR/Cas12a trans-cleavage activity using hairpin DNA reporters. Nucleic Acids Research |
Saha A, Arantes PR, Palermo G. (2022) Dynamics and mechanisms of CRISPR-Cas9 through the lens of computational methods. Current Opinion in Structural Biology. 75: 102400 |
Nierzwicki Ł, Arantes PR, Saha A, et al. (2021) Establishing the allosteric mechanism in CRISPR-Cas9. Wiley Interdisciplinary Reviews. Computational Molecular Science. 11 |
Palermo G, Spinello A, Saha A, et al. (2021) Frontiers of metal-coordinating drug design. Expert Opinion On Drug Discovery. 16: 497-511 |
Arantes PR, Saha A, Palermo G. (2020) Fighting COVID-19 Using Molecular Dynamics Simulations. Acs Central Science. 6: 1654-1656 |
Saha A, Arantes PR, Hsu RV, et al. (2020) Molecular Dynamics Reveals a DNA-Induced Dynamic Switch Triggering Activation of CRISPR-Cas12a. Journal of Chemical Information and Modeling |