Matthew R. Durk

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2009-2014 Pharmaceutical Sciences University of Toronto, Toronto, ON, Canada 
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Peng HB, Bukuroshi P, Durk MR, et al. (2021) Impact of age, hypercholesterolemia and the vitamin D receptor (VDR) on brain endogenous β-amyloid peptide accumulation in mice. Biopharmaceutics & Drug Disposition
Durk MR, Fan J, Sun H, et al. (2015) Vitamin D receptor activation induces P-glycoprotein and increases brain efflux of quinidine: an intracerebral microdialysis study in conscious rats. Pharmaceutical Research. 32: 1128-40
Durk MR, Han K, Chow EC, et al. (2014) 1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 7091-101
Chow EC, Magomedova L, Quach HP, et al. (2014) Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol. Gastroenterology. 146: 1048-59
Chow EC, Durk MR, Maeng HJ, et al. (2013) Comparative effects of 1α-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on transporters and enzymes in fxr(+/+) and fxr(-/-) mice. Biopharmaceutics & Drug Disposition. 34: 402-16
Durk MR, Chan GN, Campos CR, et al. (2012) 1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells. Journal of Neurochemistry. 123: 944-53
Chow EC, Durk MR, Cummins CL, et al. (2011) 1Alpha,25-dihydroxyvitamin D3 up-regulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of digoxin in mice in vivo. The Journal of Pharmacology and Experimental Therapeutics. 337: 846-59
Maeng HJ, Durk MR, Chow EC, et al. (2011) 1α,25-dihydroxyvitamin D3 on intestinal transporter function: studies with the rat everted intestinal sac. Biopharmaceutics & Drug Disposition. 32: 112-25
Pang KS, Durk MR. (2010) Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion. Journal of Pharmacokinetics and Pharmacodynamics. 37: 591-615
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