Clark Sehon
Affiliations: | 1997 | University of Virginia, Charlottesville, VA |
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| Harris PA, Faucher N, George N, et al. (2019) Discovery and Lead-optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. Journal of Medicinal Chemistry |
| Harris PA, Berger SB, Jeong JU, et al. (2017) Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases. Journal of Medicinal Chemistry |
| Mandal P, Berger SB, Pillay S, et al. (2014) RIP3 induces apoptosis independent of pronecrotic kinase activity. Molecular Cell. 56: 481-95 |
| Rickard DJ, Sehon CA, Kasparcova V, et al. (2014) Identification of selective small molecule inhibitors of the nucleotide-binding oligomerization domain 1 (NOD1) signaling pathway. Plos One. 9: e96737 |
| Kaiser WJ, Sridharan H, Huang C, et al. (2013) Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. The Journal of Biological Chemistry. 288: 31268-79 |
| Rickard DJ, Sehon CA, Kasparcova V, et al. (2013) Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. Plos One. 8: e69619 |
| Gatheral T, Reed DM, Moreno L, et al. (2012) A key role for the endothelium in NOD1 mediated vascular inflammation: comparison to TLR4 responses. Plos One. 7: e42386 |
| Wang GZ, Haile PA, Daniel T, et al. (2011) CCR2 receptor antagonists: optimization of biaryl sulfonamides to increase activity in whole blood. Bioorganic & Medicinal Chemistry Letters. 21: 7291-4 |
| Mapes CM, Mani NS, Deng X, et al. (2010) Practical and scalable synthesis of a selective CCK1 receptor antagonist. The Journal of Organic Chemistry. 75: 7950-3 |
| Behm DJ, Aiyar NV, Olzinski AR, et al. (2010) GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo. British Journal of Pharmacology. 161: 207-28 |