Wayne Chou
Affiliations: | 2008- | Chemistry | Brown University, Providence, RI |
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Publications
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Blank PN, Harris GG, Chou WKW, et al. (2017) Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes. Biochemistry |
Pemberton TA, Chen M, Harris GG, et al. (2017) Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases. Biochemistry |
Chou WK, Gould CA, Cane DE. (2017) Incubation of 2-methylisoborneol synthase with the intermediate analog 2-methylneryl diphosphate. The Journal of Antibiotics |
Li Z, Gao R, Hao Q, et al. (2016) The T296V Mutant of Amorpha-4,11-diene Synthase Is Defective in Allylic Diphosphate Isomerization but Retains the Ability To Cyclize the Intermediate (3R)-Nerolidyl Diphosphate to Amorpha-4,11-diene. Biochemistry. 55: 6599-6604 |
Chen M, Chou WK, Al-Lami N, et al. (2016) Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase. Biochemistry |
Chen M, Chou WK, Toyomasu T, et al. (2016) Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase. Acs Chemical Biology |
Harris GG, Lombardi PM, Pemberton TA, et al. (2015) Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence. Biochemistry |
Li R, Chou WK, Himmelberger JA, et al. (2014) Reprogramming the chemodiversity of terpenoid cyclization by remolding the active site contour of epi-isozizaene synthase. Biochemistry. 53: 1155-68 |
Köksal M, Chou WK, Cane DE, et al. (2013) Unexpected reactivity of 2-fluorolinalyl diphosphate in the active site of crystalline 2-methylisoborneol synthase. Biochemistry. 52: 5247-55 |
Köksal M, Chou WK, Cane DE, et al. (2012) Structure of 2-methylisoborneol synthase from Streptomyces coelicolor and implications for the cyclization of a noncanonical C-methylated monoterpenoid substrate. Biochemistry. 51: 3011-20 |