| Year |
Citation |
Score |
| 2023 |
Rao A, Chen N, Kim MJ, Blumenfeld J, Yip O, Hao Y, Liang Z, Nelson MR, Koutsodendris N, Grone B, Ding L, Yoon SY, Arriola P, Huang Y. Microglia Depletion Reduces Human Neuronal APOE4-Driven Pathologies in a Chimeric Alzheimer's Disease Model. Biorxiv : the Preprint Server For Biology. PMID 38014339 DOI: 10.1101/2023.11.10.566510 |
0.367 |
|
| 2023 |
Krogsaeter EK, McKetney J, Marquez A, Cakir Z, Stevenson E, Jang GM, Rao A, Zhou A, Huang Y, Krogan NJ, Swaney DL. Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction. Biorxiv : the Preprint Server For Biology. PMID 37873080 DOI: 10.1101/2023.10.02.560519 |
0.305 |
|
| 2023 |
Koutsodendris N, Blumenfeld J, Agrawal A, Traglia M, Yip O, Rao A, Kim MJ, Nelson MR, Wang YH, Grone B, Hao Y, Thomas R, Zilberter M, Yoon SY, Arriola P, ... Huang Y, et al. APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release. Cell Reports. 113252. PMID 37863057 DOI: 10.1016/j.celrep.2023.113252 |
0.329 |
|
| 2023 |
Jang SS, Tabuena DR, Grone B, Yip O, Blumenfeld J, Koutsodendris N, Ding L, Xu Q, Yoon SY, Huang Y, Zilberter M. Neuronal apoE4 induces early hyperexcitability in select populations of hippocampal neurons by altering Nell2 expression. Biorxiv : the Preprint Server For Biology. PMID 37693533 DOI: 10.1101/2023.08.28.555153 |
0.339 |
|
| 2023 |
Koutsodendris N, Blumenfeld J, Agrawal A, Traglia M, Grone B, Zilberter M, Yip O, Rao A, Nelson MR, Hao Y, Thomas R, Yoon SY, Arriola P, Huang Y. Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits. Nature Aging. 3: 275-296. PMID 37118426 DOI: 10.1038/s43587-023-00368-3 |
0.307 |
|
| 2021 |
Aery Jones EA, Rao A, Zilberter M, Djukic B, Bant JS, Gillespie AK, Koutsodendris N, Nelson M, Yoon SY, Huang K, Yuan H, Gill TM, Huang Y, Frank LM. Dentate gyrus and CA3 GABAergic interneurons bidirectionally modulate signatures of internal and external drive to CA1. Cell Reports. 37: 110159. PMID 34965435 DOI: 10.1016/j.celrep.2021.110159 |
0.699 |
|
| 2021 |
Zalocusky KA, Najm R, Taubes AL, Hao Y, Yoon SY, Koutsodendris N, Nelson MR, Rao A, Bennett DA, Bant J, Amornkul DJ, Xu Q, An A, Cisne-Thomson O, Huang Y. Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer's disease. Nature Neuroscience. PMID 33958804 DOI: 10.1038/s41593-021-00851-3 |
0.773 |
|
| 2020 |
Najm R, Zalocusky KA, Zilberter M, Yoon SY, Hao Y, Koutsodendris N, Nelson M, Rao A, Taubes A, Jones EA, Huang Y. In Vivo Chimeric Alzheimer's Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons. Cell Reports. 32: 107962. PMID 32726626 DOI: 10.1016/J.Celrep.2020.107962 |
0.421 |
|
| 2020 |
Najm R, Rao A, Huang Y. Too Much Tau in Interneurons Impairs Adult Hippocampal Neurogenesis in Alzheimer's Disease. Cell Stem Cell. 26: 297-299. PMID 32142656 DOI: 10.1016/J.Stem.2020.02.004 |
0.385 |
|
| 2019 |
Jones EA, Gillespie AK, Yoon SY, Frank LM, Huang Y. Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer's Disease Mouse Model. Cell Reports. 29: 2123-2133.e4. PMID 31747587 DOI: 10.1016/J.Celrep.2019.10.056 |
0.759 |
|
| 2019 |
Najm R, Jones EA, Huang Y. Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease. Molecular Neurodegeneration. 14: 24. PMID 31186040 DOI: 10.1186/S13024-019-0324-6 |
0.423 |
|
| 2018 |
Geier EG, Bourdenx M, Storm NJ, Cochran JN, Sirkis DW, Hwang JH, Bonham LW, Ramos EM, Diaz A, Van Berlo V, Dokuru D, Nana AL, Karydas A, Balestra ME, Huang Y, et al. Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia. Acta Neuropathologica. PMID 30382371 DOI: 10.1007/S00401-018-1925-9 |
0.328 |
|
| 2018 |
Wang C, Najm R, Xu Q, Jeong DE, Walker D, Balestra ME, Yoon SY, Yuan H, Li G, Miller ZA, Miller BL, Malloy MJ, Huang Y. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nature Medicine. PMID 29632371 DOI: 10.1038/S41591-018-0004-Z |
0.44 |
|
| 2017 |
Steele NZ, Carr JS, Bonham LW, Geier EG, Damotte V, Miller ZA, Desikan RS, Boehme KL, Mukherjee S, Crane PK, Kauwe JS, Kramer JH, Miller BL, Coppola G, Hollenbach JA, ... Huang Y, et al. Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study. Plos Medicine. 14: e1002272. PMID 28350795 DOI: 10.1371/Journal.Pmed.1002272 |
0.348 |
|
| 2017 |
Gillespie AK, Jones EA, Huang Y. Approaching Alzheimer's disease from a network level. Oncotarget. PMID 28099927 DOI: 10.18632/Oncotarget.14617 |
0.753 |
|
| 2016 |
Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MH, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, et al. Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability. Stem Cell Reports. PMID 27594585 DOI: 10.1016/J.Stemcr.2016.08.001 |
0.391 |
|
| 2016 |
Gillespie AK, Jones EA, Lin YH, Karlsson MP, Kay K, Yoon SY, Tong LM, Nova P, Carr JS, Frank LM, Huang Y. Apolipoprotein E4 Causes Age-Dependent Disruption of Slow Gamma Oscillations during Hippocampal Sharp-Wave Ripples. Neuron. PMID 27161522 DOI: 10.1016/J.Neuron.2016.04.009 |
0.767 |
|
| 2016 |
Tong LM, Yoon SY, Andrews-Zwilling Y, Yang A, Lin V, Lei H, Huang Y. Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 2316-22. PMID 26888940 DOI: 10.1523/Jneurosci.3815-15.2016 |
0.43 |
|
| 2016 |
Lalli MA, Jang J, Park JC, Wang Y, Guzman E, Zhou H, Audouard M, Bridges D, Tovar KR, Papuc SM, Tutulan-Cunita AC, Huang Y, Budisteanu M, Arghir A, Kosik KS. Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways. Human Molecular Genetics. PMID 26755828 DOI: 10.1093/Hmg/Ddw010 |
0.33 |
|
| 2016 |
Wang C, Walker D, Zhu L, Huang Y. P4-287: Eliminating TAU in Human Neurons is Neuroprotective Alzheimer's & Dementia. 12: P1143-P1143. DOI: 10.1016/J.Jalz.2016.07.029 |
0.332 |
|
| 2015 |
Wang C, Fong H, Huang Y. Direct Reprogramming of RESTing Astrocytes. Cell Stem Cell. 17: 1-3. PMID 26140600 DOI: 10.1016/J.Stem.2015.06.011 |
0.315 |
|
| 2015 |
Tong LM, Fong H, Huang Y. Stem cell therapy for Alzheimer's disease and related disorders: current status and future perspectives. Experimental & Molecular Medicine. 47: e151. PMID 25766620 DOI: 10.1038/Emm.2014.124 |
0.353 |
|
| 2014 |
Knoferle J, Yoon SY, Walker D, Leung L, Gillespie AK, Tong LM, Bien-Ly N, Huang Y. Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 14069-78. PMID 25319703 DOI: 10.1523/Jneurosci.2281-14.2014 |
0.757 |
|
| 2014 |
Huang Y, Mahley RW. Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases. Neurobiology of Disease. 72: 3-12. PMID 25173806 DOI: 10.1016/J.Nbd.2014.08.025 |
0.373 |
|
| 2014 |
Tong LM, Djukic B, Arnold C, Gillespie AK, Yoon SY, Wang MM, Zhang O, Knoferle J, Rubenstein JL, Alvarez-Buylla A, Huang Y. Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aβ accumulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 9506-15. PMID 25031394 DOI: 10.1523/Jneurosci.0693-14.2014 |
0.749 |
|
| 2014 |
Lehmann M, Ghosh PM, Madison C, Karydas A, Coppola G, O'Neil JP, Huang Y, Miller BL, Jagust WJ, Rabinovici GD. Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients. Journal of Neurology, Neurosurgery, and Psychiatry. 85: 266-73. PMID 23965289 DOI: 10.1136/Jnnp-2013-305858 |
0.328 |
|
| 2013 |
Fong H, Wang C, Knoferle J, Walker D, Balestra ME, Tong LM, Leung L, Ring KL, Seeley WW, Karydas A, Kshirsagar MA, Boxer AL, Kosik KS, Miller BL, Huang Y. Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells. Stem Cell Reports. 1: 226-34. PMID 24319659 DOI: 10.1016/J.Stemcr.2013.08.001 |
0.575 |
|
| 2013 |
Jain S, Yoon SY, Leung L, Knoferle J, Huang Y. Cellular source-specific effects of apolipoprotein (apo) E4 on dendrite arborization and dendritic spine development. Plos One. 8: e59478. PMID 23527202 DOI: 10.1371/Journal.Pone.0059478 |
0.466 |
|
| 2013 |
Vossel KA, Bien-Ly N, Bernardo A, Rascovsky K, Karydas A, Rabinovici GD, Sidhu M, Huang EJ, Miller BL, Huang Y, Seeley WW. ApoE and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron disease. Neurocase. 19: 295-301. PMID 22512241 DOI: 10.1080/13554794.2012.667124 |
0.396 |
|
| 2013 |
Andrews-Zwilling Y, Gillespie AK, Kravitz AV, Nelson AB, Devidze N, Lo I, Yoon SY, Bien-Ly N, Ring K, Zwilling D, Potter GB, Rubenstein JLR, Kreitzer AC, Huang Y. Inhibition of hilar GABAergic interneuron activity impaired spatial memory retrieval but not memory retention. Plos One. DOI: 10.1371/Journal.Pone.0040555.G006 |
0.735 |
|
| 2013 |
Tong L, Djukic B, Arnold C, Yoon SY, Rubenstein J, Alvarez-Buylla A, Huang Y. P4-338: Hilar transplantation of MGE-derived inhibitory interneuron progenitors restores normal learning and memory in Alzheimer's disease mouse models Alzheimer's & Dementia. 9: P856-P856. DOI: 10.1016/J.Jalz.2013.08.172 |
0.371 |
|
| 2013 |
Leung L, Andrews-Zwilling Y, Yoon SY, Jain S, Ring K, Dai J, Wang MM, Tong L, Walker D, Huang Y. Age-dependent impairment of hilar GABAergic interneurons and cognitive function in Apolipoprotein E-ε4 knock-in mice is modified by sex Alzheimers & Dementia. 9: 357. DOI: 10.1016/J.Jalz.2013.05.679 |
0.587 |
|
| 2012 |
Leung L, Andrews-Zwilling Y, Yoon SY, Jain S, Ring K, Dai J, Wang MM, Tong L, Walker D, Huang Y. Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice. Plos One. 7: e53569. PMID 23300939 DOI: 10.1371/Journal.Pone.0053569 |
0.652 |
|
| 2012 |
Mahley RW, Huang Y. Apolipoprotein e sets the stage: response to injury triggers neuropathology. Neuron. 76: 871-85. PMID 23217737 DOI: 10.1016/J.Neuron.2012.11.020 |
0.372 |
|
| 2012 |
Jain S, Yoon SY, Zhu L, Brodbeck J, Dai J, Walker D, Huang Y. Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development. Plos One. 7: e46340. PMID 23050017 DOI: 10.1371/Journal.Pone.0046340 |
0.382 |
|
| 2012 |
Mahley RW, Huang Y. Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology. Journal of Medicinal Chemistry. 55: 8997-9008. PMID 23013167 DOI: 10.1021/Jm3008618 |
0.331 |
|
| 2012 |
Andrews-Zwilling Y, Gillespie AK, Kravitz AV, Nelson AB, Devidze N, Lo I, Yoon SY, Bien-Ly N, Ring K, Zwilling D, Potter GB, Rubenstein JL, Kreitzer AC, Huang Y. Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. Plos One. 7: e40555. PMID 22792368 DOI: 10.1016/J.Jalz.2013.08.035 |
0.772 |
|
| 2012 |
Ring KL, Tong LM, Balestra ME, Javier R, Andrews-Zwilling Y, Li G, Walker D, Zhang WR, Kreitzer AC, Huang Y. Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell. 11: 100-9. PMID 22683203 DOI: 10.1016/J.Stem.2012.05.018 |
0.563 |
|
| 2012 |
Bien-Ly N, Gillespie AK, Walker D, Yoon SY, Huang Y. Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 4803-11. PMID 22492035 DOI: 10.1523/Jneurosci.0033-12.2012 |
0.724 |
|
| 2012 |
Chen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, ... ... Huang Y, et al. Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons. The Journal of Biological Chemistry. 287: 5253-66. PMID 22158868 DOI: 10.1074/Jbc.M111.276162 |
0.353 |
|
| 2011 |
Huang Y. Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models. Biochemical Society Transactions. 39: 924-32. PMID 21787325 DOI: 10.1042/Bst0390924 |
0.47 |
|
| 2011 |
Zwilling D, Huang SY, Sathyasaikumar KV, Notarangelo FM, Guidetti P, Wu HQ, Lee J, Truong J, Andrews-Zwilling Y, Hsieh EW, Louie JY, Wu T, Scearce-Levie K, Patrick C, Adame A, ... ... Huang Y, et al. Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. Cell. 145: 863-74. PMID 21640374 DOI: 10.1016/J.Cell.2011.05.020 |
0.341 |
|
| 2011 |
Brodbeck J, McGuire J, Liu Z, Meyer-Franke A, Balestra ME, Jeong DE, Pleiss M, McComas C, Hess F, Witter D, Peterson S, Childers M, Goulet M, Liverton N, Hargreaves R, ... ... Huang Y, et al. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. The Journal of Biological Chemistry. 286: 17217-26. PMID 21454574 DOI: 10.1074/Jbc.M110.217380 |
0.397 |
|
| 2011 |
Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Wang C, Huang Y. C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 4236-41. PMID 21368138 DOI: 10.1073/Pnas.1018381108 |
0.448 |
|
| 2011 |
Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease. The Journal of Biological Chemistry. 286: 5215-21. PMID 21118811 DOI: 10.1074/Jbc.M110.151084 |
0.352 |
|
| 2010 |
Andrews-Zwilling Y, Bien-Ly N, Xu Q, Li G, Bernardo A, Yoon SY, Zwilling D, Yan TX, Chen L, Huang Y. Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13707-17. PMID 20943911 DOI: 10.1523/Jneurosci.4040-10.2010 |
0.442 |
|
| 2010 |
Buttini M, Masliah E, Yu GQ, Palop JJ, Chang S, Bernardo A, Lin C, Wyss-Coray T, Huang Y, Mucke L. Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice. The American Journal of Pathology. 177: 563-9. PMID 20595630 DOI: 10.2353/Ajpath.2010.090973 |
0.445 |
|
| 2010 |
Huang Y. Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease. Trends in Molecular Medicine. 16: 287-94. PMID 20537952 DOI: 10.1016/J.Molmed.2010.04.004 |
0.416 |
|
| 2010 |
Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Huang Y. P1-281: C-terminal-truncated apoE4 inefficiently clears amyloid-beta peptides and synergizes with Abeta to elicit Alzheimer-like deficits in mice Alzheimer's & Dementia. 6: S255-S255. DOI: 10.1016/J.Jalz.2010.05.833 |
0.31 |
|
| 2010 |
Andrews-Zwilling YS, Bien-ly N, Xu Q, Li G, Bernardo A, Yoon SY, Zwilling D, Yan TX, Chen L, Huang Y. O4-02-02: Apolipoprotein E4 causes tau-dependent hilar GABAergic interneuron impairment, leading to learning and memory deficits in mice Alzheimer's & Dementia. 6: S153-S153. DOI: 10.1016/J.Jalz.2010.05.474 |
0.404 |
|
| 2010 |
Zwilling D, Truong J, Andrews-Zwilling Y, Hsieh E, Louie J, Huang Y, Muchowski JM, Masliah E, Schwarcz R, Muchowski PJ. An inhibitor of kynurenine 3-monooxygenase is neuroprotective in a mouse model of Alzheimer's disease Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.1975 |
0.314 |
|
| 2010 |
Jain S, Brodbeck J, Bernardo A, Walker D, Huang Y. P2-248: Arf4 regulates dendritic spine development in mouse primary neurons Alzheimer's & Dementia. 6: S387-S387. DOI: 10.1016/J.Jalz.2010.05.1297 |
0.313 |
|
| 2009 |
Li G, Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Ring K, Halabisky B, Deng C, Mahley RW, Huang Y. GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice. Cell Stem Cell. 5: 634-45. PMID 19951691 DOI: 10.1016/J.Stem.2009.10.015 |
0.659 |
|
| 2009 |
Mahley RW, Huang Y. Alzheimer disease: multiple causes, multiple effects of apolipoprotein E4, and multiple therapeutic approaches. Annals of Neurology. 65: 623-5. PMID 19557874 DOI: 10.1002/Ana.21736 |
0.308 |
|
| 2009 |
Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS. Journal of Lipid Research. 50: S183-8. PMID 19106071 DOI: 10.1194/Jlr.R800069-Jlr200 |
0.34 |
|
| 2009 |
Dellovade T, Kennan R, Wang X, Huang Y, Mahley R, Shearman MS. P4-016: Neuroimaging analysis of human apolipoprotein E targeted replacement mice that overexpress amyloid precursor protein Alzheimer's & Dementia. 5: P436-P436. DOI: 10.1016/J.Jalz.2009.04.886 |
0.351 |
|
| 2009 |
Xu Q, Savage MJ, Jeong M, Wu G, Brecht WJ, Hsieh S, Steele MX, Joachim C, Smith AD, Freedman SB, Weisgraber KH, Mahley RW, Huang Y. Apolipoprotein E fragmentation in human brain and CSF samples is isoform and Alzheimer's disease dependent Alzheimers & Dementia. 5. DOI: 10.1016/J.Jalz.2009.04.470 |
0.33 |
|
| 2008 |
Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK. Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. Proceedings of the National Academy of Sciences of the United States of America. 105: 8718-23. PMID 18562290 DOI: 10.1073/Pnas.0803526105 |
0.31 |
|
| 2008 |
Xu Q, Walker D, Bernardo A, Brodbeck J, Balestra ME, Huang Y. Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the CNS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1452-9. PMID 18256266 DOI: 10.1523/Jneurosci.3253-07.2008 |
0.423 |
|
| 2008 |
Brodbeck J, Balestra ME, Saunders AM, Roses AD, Mahley RW, Huang Y. Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons. Proceedings of the National Academy of Sciences of the United States of America. 105: 1343-6. PMID 18212130 DOI: 10.1073/Pnas.0709906104 |
0.386 |
|
| 2008 |
Huang Y. S3-02-05: APOE expression in different types of cells in the CNS: Roles in neurobiology and Alzheimer's disease Alzheimer's & Dementia. 4: T152-T152. DOI: 10.1016/J.Jalz.2008.05.382 |
0.339 |
|
| 2007 |
Mahley RW, Huang Y, Weisgraber KH. Detrimental effects of apolipoprotein E4: potential therapeutic targets in Alzheimer's disease. Current Alzheimer Research. 4: 537-40. PMID 18220516 DOI: 10.2174/156720507783018334 |
0.395 |
|
| 2006 |
Huang Y, Mahley RW. Commentary on "Perspective on a pathogenesis and treatment of Alzheimer's disease." Apolipoprotein E and the mitochondrial metabolic hypothesis. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2: 71-3. PMID 19595858 DOI: 10.1016/J.Jalz.2005.12.006 |
0.32 |
|
| 2006 |
Mahley RW, Huang Y. Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology. Acta Neurologica Scandinavica. 114: 8-14. PMID 16866905 DOI: 10.1111/J.1600-0404.2006.00679.X |
0.396 |
|
| 2006 |
Xu Q, Bernardo A, Walker D, Kanegawa T, Mahley RW, Huang Y. Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 4985-94. PMID 16687490 DOI: 10.1523/Jneurosci.5476-05.2006 |
0.4 |
|
| 2006 |
Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 103: 5644-51. PMID 16567625 DOI: 10.1073/Pnas.0600549103 |
0.394 |
|
| 2006 |
Huang Y. Apolipoprotein E and Alzheimer disease. Neurology. 66: S79-85. PMID 16432152 DOI: 10.1212/01.Wnl.0000192102.41141.9E |
0.394 |
|
| 2006 |
Ji ZS, Müllendorff K, Cheng IH, Miranda RD, Huang Y, Mahley RW. Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration. The Journal of Biological Chemistry. 281: 2683-92. PMID 16298992 DOI: 10.1074/Jbc.M506646200 |
0.339 |
|
| 2006 |
Xu Q, Bernardo A, Walker D, Kanegawa T, Mahley RW, Huang Y. O4-01-05: Profile and regulation of APOE expression in central nervous system in mice with targeting of green fluorescent protein gene to the APOE locus Alzheimer's & Dementia. 2: S75-S76. DOI: 10.1016/J.Jalz.2006.05.295 |
0.32 |
|
| 2005 |
Chang S, ran Ma T, Miranda RD, Balestra ME, Mahley RW, Huang Y. Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 102: 18694-9. PMID 16344479 DOI: 10.1073/Pnas.0508254102 |
0.301 |
|
| 2005 |
Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW. Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proceedings of the National Academy of Sciences of the United States of America. 102: 18700-5. PMID 16344478 DOI: 10.1073/Pnas.0508693102 |
0.359 |
|
| 2005 |
Ramaswamy G, Xu Q, Huang Y, Weisgraber KH. Effect of domain interaction on apolipoprotein E levels in mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10658-63. PMID 16291938 DOI: 10.1523/Jneurosci.1922-05.2005 |
0.39 |
|
| 2004 |
Harris FM, Brecht WJ, Xu Q, Mahley RW, Huang Y. Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc. The Journal of Biological Chemistry. 279: 44795-801. PMID 15322121 DOI: 10.1074/Jbc.M408127200 |
0.383 |
|
| 2004 |
Huang Y, Weisgraber KH, Mucke L, Mahley RW. Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 23: 189-204. PMID 15181247 DOI: 10.1385/Jmn:23:3:189 |
0.417 |
|
| 2004 |
Raber J, Huang Y, Ashford JW. ApoE genotype accounts for the vast majority of AD risk and AD pathology. Neurobiology of Aging. 25: 641-50. PMID 15172743 DOI: 10.1016/J.Neurobiolaging.2003.12.023 |
0.389 |
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| 2004 |
Xu Q, Brecht WJ, Weisgraber KH, Mahley RW, Huang Y. Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer. The Journal of Biological Chemistry. 279: 25511-6. PMID 15054100 DOI: 10.1074/Jbc.M311256200 |
0.301 |
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| 2004 |
Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2527-34. PMID 15014128 DOI: 10.1523/Jneurosci.4315-03.2004 |
0.456 |
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| 2004 |
Harris FM, Tesseur I, Brecht WJ, Xu Q, Mullendorff K, Chang S, Wyss-Coray T, Mahley RW, Huang Y. Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease. The Journal of Biological Chemistry. 279: 3862-8. PMID 14585838 DOI: 10.1074/Jbc.M309475200 |
0.403 |
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| 2004 |
Brecht WJ, Harris FM, Chang S, Tesseur I, Yu G, Fish JD, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y. P2-292 Neuron-specific apoE4 proteolysis is associated with increased tau phosphorylation in the brains of transgenic mice Neurobiology of Aging. 25: S316. DOI: 10.1016/S0197-4580(04)81037-6 |
0.374 |
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| 2004 |
Xu Q, Brecht WJ, Dee Fish J, Walker D, Yu G, Mahley RW, Huang Y. O1-03-03 APOE in degenerating neurons is produced by neurons rather than taken up from astrocytes Neurobiology of Aging. 25: S14. DOI: 10.1016/S0197-4580(04)80046-0 |
0.324 |
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| 2003 |
Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 10966-71. PMID 12939405 DOI: 10.1073/Pnas.1434398100 |
0.492 |
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| 2003 |
Hopkins PC, Huang Y, McGuire JG, Pitas RE. Evidence for differential effects of apoE3 and apoE4 on HDL metabolism. Journal of Lipid Research. 43: 1881-9. PMID 12401887 DOI: 10.1194/Jlr.M200172-Jlr200 |
0.383 |
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| 2002 |
Buttini M, Yu GQ, Shockley K, Huang Y, Jones B, Masliah E, Mallory M, Yeo T, Longo FM, Mucke L. Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10539-48. PMID 12486146 DOI: 10.1523/Jneurosci.22-24-10539.2002 |
0.434 |
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| 2002 |
Ji ZS, Miranda RD, Newhouse YM, Weisgraber KH, Huang Y, Mahley RW. Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells. The Journal of Biological Chemistry. 277: 21821-8. PMID 11912196 DOI: 10.1074/Jbc.M112109200 |
0.319 |
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| 2001 |
Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW. Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons. Proceedings of the National Academy of Sciences of the United States of America. 98: 8838-43. PMID 11447277 DOI: 10.1073/Pnas.151254698 |
0.426 |
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| 2000 |
Langer C, Huang Y, Cullen P, Wiesenhütter B, Mahley RW, Assmann G, Eckardstein Av. Endogenous apolipoprotein E modulates cholesterol efflux and cholesteryl ester hydrolysis mediated by high-density lipoprotein-3 and lipid-free apolipoproteins in mouse peritoneal macrophages Journal of Molecular Medicine. 78: 217-227. PMID 10933584 DOI: 10.1007/S001090000096 |
0.302 |
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| 2000 |
Huang Y, Liu XQ, Mahley RW. Differential effects of cytosolic apolipoprotein (APO) E3 and APOE4 on neurite outgrowth and the cytoskeleton Neurobiology of Aging. 21: 216. DOI: 10.1016/S0197-4580(00)83304-7 |
0.336 |
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| 1999 |
Huang Y, Ji ZS, Brecht WJ, Rall SC, Taylor JM, Mahley RW. Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis. Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 2952-9. PMID 10591675 DOI: 10.1161/01.Atv.19.12.2952 |
0.313 |
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| 1999 |
Mahley RW, Huang Y. Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond. Current Opinion in Lipidology. 10: 207-218. PMID 10431657 DOI: 10.1097/00041433-199906000-00003 |
0.336 |
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| 1998 |
Huang Y, Liu XQ, Rall SC, Taylor JM, Eckardstein AV, Assmann G, Mahley RW. Overexpression and Accumulation of Apolipoprotein E as a Cause of Hypertriglyceridemia Journal of Biological Chemistry. 273: 26388-26393. PMID 9756870 DOI: 10.1074/Jbc.273.41.26388 |
0.375 |
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| 1998 |
Huang Y, Liu XQ, Rall SC, Mahley RW. Apolipoprotein E2 Reduces The Low Density Lipoprotein Level In Transgenic Mice By Impairing Lipoprotein Lipase-Mediated Lipolysis Of Triglyceride-Rich Lipoproteins Journal of Biological Chemistry. 273: 17483-17490. PMID 9651338 DOI: 10.1074/Jbc.273.28.17483 |
0.343 |
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| 1998 |
Fan J, Ji Z-, Huang Y, Silva HD, Sanan D, Mahley RW, Innerarity TL, Taylor JM. Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma. Journal of Clinical Investigation. 101: 2151-2164. PMID 9593771 DOI: 10.1172/Jci1599 |
0.344 |
|
| 1997 |
Huang Y, Rall SC, Mahley RW. Genetic Factors Precipitating Type III Hyperlipoproteinemia in Hypolipidemic Transgenic Mice Expressing Human Apolipoprotein E2 Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 2817-2824. PMID 9409260 DOI: 10.1161/01.Atv.17.11.2817 |
0.352 |
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| 1997 |
Huang Y, Zhu Y, Langer C, Raabe M, Wu S, Wiesenhütter B, Seedorf U, Maeda N, Assmann G, von Eckardstein A. Effects of genotype and diet on cholesterol efflux into plasma and lipoproteins of normal, apolipoprotein A-I-, and apolipoprotein E-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 2010-9. PMID 9351366 DOI: 10.1161/01.Atv.17.10.2010 |
0.322 |
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| 1997 |
Huang Y, Schwendner SW, Rall SC, Sanan DA, Mahley RW. Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis Journal of Biological Chemistry. 272: 22685-22694. PMID 9312550 DOI: 10.1074/Jbc.272.36.22685 |
0.3 |
|
| 1997 |
von Eckardstein A, Zhu Y, Huang Y, Langer C, Wiesenhütter B, Assmann G. 4.P.397 Cholesterol efflux into plasma and lipoproteins of normal, ApoA-I, and ApoE-deficient mice Atherosclerosis. 134: 380. DOI: 10.1016/S0021-9150(97)89922-4 |
0.326 |
|
| 1996 |
Huang Y, Schwendner SW, Rall SC, Mahley RW. Hypolipidemic and Hyperlipidemic Phenotypes in Transgenic Mice Expressing Human Apolipoprotein E2 Journal of Biological Chemistry. 271: 29146-29151. PMID 8910571 DOI: 10.1074/Jbc.271.46.29146 |
0.385 |
|
| 1994 |
Huang Y, Eckardstein AV, Wu S, Maeda N, Assmann G. A plasma lipoprotein containing only apolipoprotein E and with gamma mobility on electrophoresis releases cholesterol from cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 1834-1838. PMID 8127890 DOI: 10.1073/Pnas.91.5.1834 |
0.324 |
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