Gregory D. Friedland, Ph.D.

Affiliations: 
Biophysics University of California, San Francisco, San Francisco, CA 
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"Gregory Friedland"

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Tanja Kortemme grad student 2008 UCSF
 (A correspondence between solution-state dynamics of an individual protein and the sequence and conformational diversity of its family: Implications for improving protein design.)
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Heins RA, Cheng X, Nath S, et al. (2014) Phylogenomically guided identification of industrially relevant GH1 β-glucosidases through DNA synthesis and nanostructure-initiator mass spectrometry. Acs Chemical Biology. 9: 2082-91
McAndrew RP, Park JI, Heins RA, et al. (2013) From soil to structure, a novel dimeric β-glucosidase belonging to glycoside hydrolase family 3 isolated from compost using metagenomic analysis. The Journal of Biological Chemistry. 288: 14985-92
Chen Z, Friedland GD, Pereira JH, et al. (2012) Tracing determinants of dual substrate specificity in glycoside hydrolase family 5. The Journal of Biological Chemistry. 287: 25335-43
Dey SS, Xue Y, Joachimiak MP, et al. (2012) Mutual information analysis reveals coevolving residues in Tat that compensate for two distinct functions in HIV-1 gene expression. The Journal of Biological Chemistry. 287: 7945-55
Friedland GD, Kortemme T. (2010) Designing ensembles in conformational and sequence space to characterize and engineer proteins. Current Opinion in Structural Biology. 20: 377-84
Friedland GD, Lakomek NA, Griesinger C, et al. (2009) A correspondence between solution-state dynamics of an individual protein and the sequence and conformational diversity of its family. Plos Computational Biology. 5: e1000393
Freedman TS, Sondermann H, Kuchment O, et al. (2009) Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1. Structure (London, England : 1993). 17: 41-53
Friedland GD, Linares AJ, Smith CA, et al. (2008) A simple model of backbone flexibility improves modeling of side-chain conformational variability. Journal of Molecular Biology. 380: 757-74
Freedman TS, Sondermann H, Friedland GD, et al. (2006) A Ras-induced conformational switch in the Ras activator Son of sevenless. Proceedings of the National Academy of Sciences of the United States of America. 103: 16692-7
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