Kathleen Sprouffske, Ph.D.
Affiliations: | 2011 | University of Pennsylvania, Philadelphia, PA, United States |
Area:
Genetics, Medicine and Surgery, Cell BiologyGoogle:
"Kathleen Sprouffske"Parents
Sign in to add mentor| Carlo C. Maley | grad student | 2011 | Penn | |
| (Modeling the evolutionary and differentiation dynamics of neoplastic progression.) | ||||
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Publications
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| Elgrail MM, Sprouffske K, Dartey JO, et al. (2024) Emergence of a multilocus mutator genotype in mutator Escherichia coli experimental populations under repeated lethal selection. Journal of Evolutionary Biology |
| Mermet-Meillon F, Mercan S, Bauer-Probst B, et al. (2024) Protein destabilization underlies pathogenic missense mutations in ARID1B. Nature Structural & Molecular Biology |
| Rago F, Rodrigues LU, Bonney M, et al. (2021) Exquisite Sensitivity to Dual BRG1/BRM ATPase Inhibitors Reveals Broad SWI/SNF Dependencies in Acute Myeloid Leukemia. Molecular Cancer Research : McR |
| Merlo LMF, Sprouffske K, Howard TC, et al. (2020) Application of simultaneous selective pressures slows adaptation. Evolutionary Applications. 13: 1615-1625 |
| Rago F, Elliott G, Li A, et al. (2020) The discovery of SWI/SNF chromatin remodeling activity as a novel and targetable dependency in uveal melanoma. Molecular Cancer Therapeutics |
| Sprouffske K, Kerr G, Li C, et al. (2020) Genetic heterogeneity and clonal evolution during metastasis in breast cancer patient-derived tumor xenograft models. Computational and Structural Biotechnology Journal. 18: 323-331 |
| Bleu M, Gaulis S, Lopes R, et al. (2019) PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma. Nature Communications. 10: 3739 |
| Cotton JL, KrishnamurthyRadhakrishna V, Chen J, et al. (2019) Abstract A122: Molecular barcoding and single cell approaches to investigate drug tolerance in EGFRmut NSCLC Molecular Cancer Therapeutics. 18 |
| Sprouffske K, Aguílar-Rodríguez J, Sniegowski P, et al. (2018) High mutation rates limit evolutionary adaptation in Escherichia coli. Plos Genetics. 14: e1007324 |
| Chu HY, Sprouffske K, Wagner A. (2018) Assessing the benefits of horizontal gene transfer by laboratory evolution and genome sequencing. Bmc Evolutionary Biology. 18: 54 |