Aroop Sircar, Ph.D.
Affiliations: | 2010 | Johns Hopkins University, Baltimore, MD |
Area:
General Biophysics, Bioinformatics Biology, Chemical EngineeringGoogle:
"Aroop Sircar"Parents
Sign in to add mentor| Jeffrey J. Gray | grad student | 2010 | Johns Hopkins | |
| (Computational antibody structure prediction and antibody-antigen docking.) | ||||
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Publications
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| Lan Y, Zhang D, Xu C, et al. (2018) Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β. Science Translational Medicine. 10 |
| Miklos AE, Kluwe C, Der BS, et al. (2012) Structure-based design of supercharged, highly thermoresistant antibodies. Chemistry & Biology. 19: 449-55 |
| Sircar A. (2012) Methods for the homology modeling of antibody variable regions. Methods in Molecular Biology (Clifton, N.J.). 857: 301-11 |
| Fleishman SJ, Whitehead TA, Strauch EM, et al. (2011) Community-wide assessment of protein-interface modeling suggests improvements to design methodology. Journal of Molecular Biology. 414: 289-302 |
| Sircar A, Sanni KA, Shi J, et al. (2011) Analysis and modeling of the variable region of camelid single-domain antibodies Journal of Immunology. 186: 6357-6367 |
| Bocik WE, Sircar A, Gray JJ, et al. (2011) Mechanism of polyubiquitin chain recognition by the human ubiquitin conjugating enzyme Ube2g2. The Journal of Biological Chemistry. 286: 3981-91 |
| Sircar A, Chaudhury S, Kilambi KP, et al. (2010) A generalized approach to sampling backbone conformations with RosettaDock for CAPRI rounds 13-19 Proteins: Structure, Function and Bioinformatics. 78: 3115-3123 |
| Sircar A, Gray JJ. (2010) SnugDock: Paratope structural optimization during antibody-antigen docking compensates for errors in antibody homology models Plos Computational Biology. 6 |
| Sircar A, Kim ET, Gray JJ. (2009) RosettaAntibody: Antibody variable region homology modeling server Nucleic Acids Research. 37: W474-W479 |
| Sivasubramanian A, Sircar A, Chaudhury S, et al. (2009) Toward high-resolution homology modeling of antibody F v regions and application to antibody-antigen docking Proteins: Structure, Function and Bioinformatics. 74: 497-514 |