Philip E. Schaner, Ph.D.

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
globin gene switching, familial mediterranean fever, intestinal development
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"Philip Schaner"

Parents

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Deborah L. Gumucio grad student 2005 University of Michigan
 (A characterization of pyrin: Investigating the molecular pathophysiology of familial Mediterranean fever.)
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Publications

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Waite AL, Schaner P, Richards N, et al. (2009) Pyrin Modulates the Intracellular Distribution of PSTPIP1. Plos One. 4: e6147
Waite AL, Schaner P, Hu C, et al. (2009) Pyrin and ASC Co-localize to cellular sites that are rich in polymerizing actin Experimental Biology and Medicine. 234: 40-52
Balci-Peynircioglu B, Waite AL, Schaner P, et al. (2008) Expression of ASC in renal tissues of familial mediterranean fever patients with amyloidosis: postulating a role for ASC in AA type amyloid deposition. Experimental Biology and Medicine (Maywood, N.J.). 233: 1324-33
Schaner PE, Gumucio DL. (2005) Familial Mediterranean fever in the post-genomic era: How an ancient disease is providing new insights into inflammatory pathways Current Drug Targets: Inflammation and Allergy. 4: 67-76
Diaz A, Hu C, Kastner DL, et al. (2004) Lipopolysaccharide-induced expression of multiple alternatively spliced MEFV transcripts in human synovial fibroblasts: A prominent splice isoform lacks the C-terminal domain that is highly mutated in familial Mediterranean fever Arthritis and Rheumatism. 50: 3679-3689
Anderson JP, Mueller JL, Rosengren S, et al. (2004) Structural, expression, and evolutionary analysis of mouse CIAS1. Gene. 338: 25-34
Masumoto J, Dowds TA, Schaner P, et al. (2003) ASC is an activating adaptor for NF-κB and caspase-8-dependent apoptosis Biochemical and Biophysical Research Communications. 303: 69-73
Gumucio DL, Diaz A, Schaner P, et al. (2002) Fire and ICE: The role of pyrin domain-containing proteins in inflammation and apoptosis Clinical and Experimental Rheumatology. 20: S45-S53
Richards N, Schaner P, Diaz A, et al. (2001) Interaction between Pyrin and the Apoptotic Speck Protein (ASC) Modulates ASC-induced Apoptosis Journal of Biological Chemistry. 276: 39320-39329
Kennell JA, Richards NW, Schaner PE, et al. (2001) cDNA cloning, chromosomal localization and evolutionary analysis of mouse vacuolar ATPase subunit D, Atp6m Cytogenetics and Cell Genetics. 92: 337-341
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