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Zachary T. Britton, Ph.D.

Affiliations: 
2012 Department of Chemical Engineering University of Delaware, Newark, DE, United States 
Area:
Chemical Engineering, Biochemistry
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Anne Skaja Robinson grad student 2012 University of Delaware
 (Novel approaches to the expression and purification of G protein-coupled receptors.)

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Dodd R, Schofield DJ, Wilkinson T, et al. (2020) Generating therapeutic monoclonal antibodies to complex multi-spanning membrane targets: Overcoming the antigen challenge and enabling discovery strategies. Methods (San Diego, Calif.)
Jain AR, Britton ZT, Markwalter CE, et al. (2020) Improved ligand-binding- and signaling-competent human NK2R yields in yeast using a chimera with the rat NK2R C-terminus enable NK2R-G protein signaling platform. Protein Engineering, Design & Selection : Peds
Britton ZT, London TB, Carrell J, et al. (2019) Tag-on-Demand: exploiting amber codon suppression technology for the enrichment of high-expressing membrane protein cell lines. Protein Engineering, Design & Selection : Peds
Blocker KM, Britton ZT, Naranjo AN, et al. (2015) Recombinant G protein-coupled receptor expression in Saccharomyces cerevisiae for protein characterization. Methods in Enzymology. 556: 165-83
Britton ZT, Hanle EI, Robinson AS. (2012) An expression and purification system for the biosynthesis of adenosine receptor peptides for biophysical and structural characterization. Protein Expression and Purification. 84: 224-35
Young CL, Britton ZT, Robinson AS. (2012) Recombinant protein expression and purification: a comprehensive review of affinity tags and microbial applications. Biotechnology Journal. 7: 620-34
Britton ZT, Hanle EI, Robinson AS. (2011) Expression and Purification of G Protein-Coupled Receptor (GPCR) Transmembrane Peptides Biophysical Journal. 100: 381a
O'Malley MA, Lazarova T, Britton ZT, et al. (2007) High-level expression in Saccharomyces cerevisiae enables isolation and spectroscopic characterization of functional human adenosine A2a receptor. Journal of Structural Biology. 159: 166-78
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