Thomas P. Kole, Ph.D.

Affiliations: 
2004 Johns Hopkins University, Baltimore, MD 
Area:
General Biophysics, Biomedical Engineering, Cell Biology
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"Thomas Kole"

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Denis Wirtz grad student 2004 Johns Hopkins
 (Intracellular mechanics of cell migration and RhoGTPase mediated cytoskeleton reorganization.)
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Publications

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Linde ME, Colquhoun DR, Ubaida Mohien C, et al. (2013) The conserved set of host proteins incorporated into HIV-1 virions suggests a common egress pathway in multiple cell types. Journal of Proteome Research. 12: 2045-54
Delgoffe GM, Kole TP, Cotter RJ, et al. (2009) Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation. Molecular Immunology. 46: 2694-8
Delgoffe GM, Kole TP, Zheng Y, et al. (2009) The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity. 30: 832-44
Delgoffe GM, Kole TP, Zheng Y, et al. (2008) TOR Complex 1 and TOR Complex 2 Differentially Regulate Effector and Regulatory T Cell Differentiation Blood. 112: 675-675
Panorchan P, Lee JS, Daniels BR, et al. (2007) Probing cellular mechanical responses to stimuli using ballistic intracellular nanorheology. Methods in Cell Biology. 83: 115-40
Zheng Y, Collins SL, Lutz MA, et al. (2007) A role for mammalian target of rapamycin in regulating T cell activation versus anergy. Journal of Immunology (Baltimore, Md. : 1950). 178: 2163-70
Panorchan P, Lee JS, Kole TP, et al. (2006) Microrheology and ROCK signaling of human endothelial cells embedded in a 3D matrix. Biophysical Journal. 91: 3499-507
Lee JS, Panorchan P, Hale CM, et al. (2006) Ballistic intracellular nanorheology reveals ROCK-hard cytoplasmic stiffening response to fluid flow. Journal of Cell Science. 119: 1760-8
Tseng Y, Kole TP, Lee JS, et al. (2005) How actin crosslinking and bundling proteins cooperate to generate an enhanced cell mechanical response. Biochemical and Biophysical Research Communications. 334: 183-92
Gupton SL, Anderson KL, Kole TP, et al. (2005) Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin. The Journal of Cell Biology. 168: 619-31
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