Michael W. Handlogten, Ph.D.
Affiliations: | 2013 | University of Notre Dame, Notre Dame, IN, United States |
Area:
Biomedical Engineering, Biochemistry, Molecular BiologyGoogle:
"Michael Handlogten"Parents
Sign in to add mentor| Z. Başar Bilgiçer | grad student | 2013 | Notre Dame (Chemistry Tree) | |
| (Design of a heterobivalent inhibitor of allergy and more physiologically relevant allergy models.) | ||||
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Publications
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| Handlogten MW, Bosley S, Dunn S, et al. (2023) Accelerated cell culture process development and characterization for cilgavimab/tixagevimab (AZD7442) for the prevention and treatment of COVID-19. Biotechnology and Bioengineering |
| Handlogten MW, Peng L, Christian EA, et al. (2020) Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region. Mabs. 12: 1779974 |
| Handlogten MW, Wang J, Ahuja S. (2020) Online Control of Cell Culture Redox Potential Prevents Antibody Interchain Disulfide Bond Reduction. Biotechnology and Bioengineering |
| Swope N, Keen Chung W, Cao M, et al. (2020) Impact of enzymatic reduction on bivalent bispecific antibody fragmentation and loss of product purity upon reoxidation. Biotechnology and Bioengineering |
| Handlogten MW, Zhu M, Ahuja S. (2018) Intracellular response of CHO cells to oxidative stress and its influence on metabolism and antibody production Biochemical Engineering Journal. 133: 12-20 |
| Handlogten MW, Lee-O'Brien A, Roy G, et al. (2017) Intracellular Response to Process Optimization and Impact on Productivity and Product Aggregates for a high-titer CHO Cell Process. Biotechnology and Bioengineering |
| Handlogten MW, Zhu M, Ahuja S. (2017) Glutathione and thioredoxin systems contribute to recombinant monoclonal antibody interchain disulfide bond reduction during bioprocessing. Biotechnology and Bioengineering |
| Chung WK, Russell B, Yang Y, et al. (2017) Effects of antibody disulfide bond reduction on purification process performance and final drug substance stability. Biotechnology and Bioengineering |
| Handlogten MW, Deak PE, Bilgicer B. (2014) Two-allergen model reveals complex relationship between IgE crosslinking and degranulation. Chemistry & Biology. 21: 1445-51 |
| Handlogten MW, Stefanick JF, Deak PE, et al. (2014) Affinity-based precipitation via a bivalent peptidic hapten for the purification of monoclonal antibodies. The Analyst. 139: 4247-55 |