Xiaochao Wei, Ph.D.

Affiliations: 
2007 University of Rochester, Rochester, NY 
Area:
Pathology, Molecular Biology
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"Xiaochao Wei"

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Regis J. O'Keefe grad student 2007 Rochester
 (Studies of signaling pathways in cellular responses to titanium particles: Implications of cyclooxygenase-2/prostaglandin E2/RANK ligand induction in fibroblasts during wear debris-induced osteolysis.)
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Publications

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Wei X, Zhang X, Flick LM, et al. (2009) Titanium particles stimulate COX-2 expression in synovial fibroblasts through an oxidative stress-induced, calpain-dependent, NF-kappaB pathway. American Journal of Physiology. Cell Physiology. 297: C310-20
Tsutsumi R, Xie C, Wei X, et al. (2009) PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 1753-62
Wang Q, Wei X, Zhu T, et al. (2007) Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2. The Journal of Biological Chemistry. 282: 10742-8
Wei X, Zhang X, Zuscik MJ, et al. (2005) Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 20: 1136-48
Bukata SV, Gelinas J, Wei X, et al. (2004) PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 22: 6-12
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