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Christopher G. Hubert, Ph.D. - Publications

Affiliations: 
2012 Molecular and Cellular Biology University of Washington, Seattle, Seattle, WA 
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Song X, Tiek D, Miki S, Huang T, Lu M, Goenka A, Iglesia RP, Yu X, Wu R, Walker MN, Zeng C, Shah H, Weng SHS, Huff A, Zhang W, ... ... Hubert CG, et al. RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic targets in adult glioma. The Journal of Clinical Investigation. PMID 38662454 DOI: 10.1172/JCI173789  0.361
2023 Verduin M, Hoosemans L, Vanmechelen M, van Heumen M, Piepers JAF, Astuti G, Ackermans L, Schijns OEMG, Kampen KR, Tjan-Heijnen VCG, de Barbanson BA, Postma AA, Eekers DBP, Broen MPG, Beckervordersandforth J, ... ... Hubert CG, et al. Patient-derived glioblastoma organoids reflect tumor heterogeneity and treatment sensitivity. Neuro-Oncology Advances. 5: vdad152. PMID 38130902 DOI: 10.1093/noajnl/vdad152  0.333
2023 Hubert CG, Stauffer SR, Lathia JD. A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer. Plos Biology. 21: e3002295. PMID 37713380 DOI: 10.1371/journal.pbio.3002295  0.437
2023 Mitchell K, Sprowls SA, Arora S, Shakya S, Silver DJ, Goins CM, Wallace L, Roversi G, Schafer R, Kay K, Miller TE, Lauko A, Bassett J, Kashyap A, D'Amato Kass J, ... ... Hubert CG, et al. WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma. Genes & Development. PMID 36732025 DOI: 10.1101/gad.349803.122  0.466
2022 Sundar SJ, Shakya S, Recinos V, Hubert CG. Maintaining Human Glioblastoma Cellular Diversity Ex vivo using Three-Dimensional Organoid Culture. Journal of Visualized Experiments : Jove. PMID 36094291 DOI: 10.3791/63745  0.37
2022 Shields JA, Meier SR, Bandi M, Mulkearns-Hubert EE, Hajdari N, Dam Ferdinez M, Engel JL, Silver DJ, Shen B, Zhang W, Hubert CG, Mitchell K, Shakya S, Zhao SC, Bejnood A, et al. VRK1 is a Synthetic Lethal Target in VRK2-deficient Glioblastoma. Cancer Research. PMID 36069976 DOI: 10.1158/0008-5472.CAN-21-4443  0.384
2022 Hubert CG, Rich JN. Patient-derived explants as tumor models. Cancer Cell. 40: 348-350. PMID 35364017 DOI: 10.1016/j.ccell.2022.03.004  0.383
2021 Knudsen AM, Halle B, Cédile O, Burton M, Baun C, Thisgaard H, Anand A, Hubert C, Thomassen M, Michaelsen SR, Olsen BB, Dahlrot RH, Bjerkvig R, Lathia JD, Kristensen BW. Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors. Neuro-Oncology. PMID 34964899 DOI: 10.1093/neuonc/noab302  0.328
2021 Sundar SJ, Shakya S, Barnett A, Wallace LC, Jeon H, Sloan A, Recinos V, Hubert CG. Three-dimensional organoid culture unveils resistance to clinical therapies in adult and pediatric glioblastoma. Translational Oncology. 15: 101251. PMID 34700192 DOI: 10.1016/j.tranon.2021.101251  0.326
2021 Shakya S, Gromovsky AD, Hale JS, Knudsen AM, Prager B, Wallace LC, Penalva LOF, Brown HA, Kristensen BW, Rich JN, Lathia JD, Brown JM, Hubert CG. Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches. Acta Neuropathologica Communications. 9: 101. PMID 34059134 DOI: 10.1186/s40478-021-01205-7  0.363
2020 Prager BC, Bhargava S, Mahadev V, Hubert CG, Rich JN. Glioblastoma Stem Cells: Driving Resilience through Chaos. Trends in Cancer. 6: 223-235. PMID 32101725 DOI: 10.1016/j.trecan.2020.01.009  0.399
2019 Wallace L, Gromovsky A, Hale J, Knudsen A, Prager B, Silver D, Sloan A, Kristensen B, Lathia J, Mark Brown J, Rich J, Hubert C. STEM-26. ALTERED LIPID METABOLISM MARKS GLIOBLASTOMA STEM AND NON-STEM CELLS IN SEPARATE TUMOR NICHES Neuro-Oncology. 21: vi239-vi239. DOI: 10.1093/neuonc/noz175.999  0.403
2018 Yi C, Li G, Ivanov DN, Wang Z, Velasco M, Hernandez G, Kaundal S, Villarreal J, Gupta YK, Qiao M, Hubert CG, Hart MJ, Penalva LOF. Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells. Rna Biology. PMID 30362859 DOI: 10.1080/15476286.2018.1539607  0.483
2018 Wang X, Prager BC, Wu Q, Kim LJY, Gimple RC, Shi Y, Yang K, Morton AR, Zhou W, Zhu Z, Obara EAA, Miller TE, Song A, Lai S, Hubert CG, et al. Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression. Cell Stem Cell. 22: 514-528.e5. PMID 29625067 DOI: 10.1016/J.Stem.2018.03.011  0.505
2017 Mack SC, Pajtler KW, Chavez L, Okonechnikov K, Bertrand KC, Wang X, Erkek S, Federation A, Song A, Lee C, Wang X, McDonald L, Morrow JJ, Saiakhova A, Sin-Chan P, ... ... Hubert CG, et al. Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling. Nature. PMID 29258295 DOI: 10.1038/Nature25169  0.335
2017 Zhu Z, Gorman MJ, McKenzie LD, Chai JN, Hubert CG, Prager BC, Fernandez E, Richner JM, Zhang R, Shan C, Tycksen E, Wang X, Shi PY, Diamond MS, Rich JN, et al. Correction: Zika virus has oncolytic activity against glioblastoma stem cells. The Journal of Experimental Medicine. PMID 28916645 DOI: 10.1084/Jem.2017109309122017C  0.365
2017 Zhu Z, Gorman MJ, McKenzie LD, Chai JN, Hubert CG, Prager BC, Fernandez E, Richner JM, Zhang R, Shan C, Wang X, Shi PY, Diamond MS, Rich JN, Chheda MG. Zika virus has oncolytic activity against glioblastoma stem cells. The Journal of Experimental Medicine. PMID 28874392 DOI: 10.1084/Jem.20171093  0.426
2017 Wang X, Huang Z, Wu Q, Prager BC, Mack SC, Yang K, Kim LJY, Gimple RC, Shi Y, Lai S, Xie Q, Miller TE, Hubert CG, Song A, Dong Z, et al. MYC-regulated Mevalonate Metabolism Maintains Brain Tumor Initiating Cells. Cancer Research. PMID 28729418 DOI: 10.1158/0008-5472.Can-17-0114  0.457
2017 Miller TE, Liau BB, Wallace LC, Morton AR, Xie Q, Dixit D, Factor DC, Kim LJY, Morrow JJ, Wu Q, Mack SC, Hubert CG, Gillespie SM, Flavahan WA, Hoffmann T, et al. Transcription elongation factors represent in vivo cancer dependencies in glioblastoma. Nature. PMID 28678782 DOI: 10.1038/Nature23000  0.379
2017 Marcelino Meliso F, Hubert CG, Favoretto Galante PA, Penalva LO. RNA processing as an alternative route to attack glioblastoma. Human Genetics. PMID 28608251 DOI: 10.1007/s00439-017-1819-2  0.438
2017 Jung J, Kim LJY, Wang X, Wu Q, Sanvoranart T, Hubert CG, Prager BC, Wallace LC, Jin X, Mack SC, Rich JN. Nicotinamide metabolism regulates glioblastoma stem cell maintenance. Jci Insight. 2. PMID 28515364 DOI: 10.1172/jci.insight.90019  0.38
2017 Wang X, Yang K, Xie Q, Wu Q, Mack SC, Shi Y, Kim LJ, Prager BC, Flavahan WA, Liu X, Singer M, Hubert CG, Miller TE, Zhou W, Huang Z, et al. Purine synthesis promotes maintenance of brain tumor initiating cells in glioma. Nature Neuroscience. PMID 28346452 DOI: 10.1038/Nn.4537  0.475
2017 Ayuso JM, Monge R, Martínez-González A, Virumbrales-Muñoz M, Llamazares GA, Berganzo J, Hernández-Laín A, Santolaria J, Doblaré M, Hubert C, Rich JN, Sánchez-Gómez P, Pérez-García VM, Ochoa I, Fernández LJ. Glioblastoma on a microfluidic chip: Generating pseudopalisades and enhancing aggressiveness through blood vessel obstruction events. Neuro-Oncology. PMID 28062831 DOI: 10.1093/Neuonc/Now230  0.31
2017 Miller TE, Liau B, Wallace LC, Morton A, Xie Q, Dixit D, Factor D, Kim L, Morrow J, Wu Q, Mack S, Hubert C, Paddison PJ, Horbinski C, Bernstein B, et al. GENE-30. TRANSCRIPTION ELONGATION FACTORS REPRESENT IN VIVO CANCER DEPENDENCIES IN GLIOBLASTOMA Neuro-Oncology. 19: vi99-vi99. DOI: 10.1093/Neuonc/Nox168.404  0.355
2017 Hubert C, Rivera M, Wallace LC, Wu Q, Mack S, Prager B, Miller TE, Couce M, McLendon R, Sloan A, Rich J. TMOD-16. MODELING GLIOBLASTOMA THROUGH CANCER STEM CELL ORGANOIDS Neuro-Oncology. 19: vi257-vi257. DOI: 10.1093/Neuonc/Nox168.1054  0.458
2016 Hubert CG, Rivera M, Spangler LC, Wu Q, Mack SC, Prager BC, Couce M, McLendon RE, Sloan AE, Rich JN. A three-dimensional organoid culture system derived from human glioblastomas recapitulates the hypoxic gradients and cancer stem cell heterogeneity of tumors found in vivo. Cancer Research. PMID 26896279 DOI: 10.1158/0008-5472.Can-15-2402  0.499
2015 Mack SC, Hubert CG, Miller TE, Taylor MD, Rich JN. An epigenetic gateway to brain tumor cell identity. Nature Neuroscience. 19: 10-9. PMID 26713744 DOI: 10.1038/nn.4190  0.461
2015 Hitomi M, Deleyrolle LP, Mulkearns-Hubert EE, Jarrar A, Li M, Sinyuk M, Otvos B, Brunet S, Flavahan WA, Hubert CG, Goan W, Hale JS, Alvarado AG, Zhang A, Rohaus M, et al. Differential connexin function enhances self-renewal in glioblastoma. Cell Reports. 11: 1031-42. PMID 25959821 DOI: 10.1016/J.Celrep.2015.04.021  0.375
2015 Xie Q, Wu Q, Mack SC, Yang K, Kim L, Hubert CG, Flavahan WA, Chu C, Bao S, Rich JN. CDC20 maintains tumor initiating cells. Oncotarget. 6: 13241-54. PMID 25938542 DOI: 10.18632/Oncotarget.3676  0.486
2015 Adorno-Cruz V, Kibria G, Liu X, Doherty M, Junk DJ, Guan D, Hubert C, Venere M, Mulkearns-Hubert E, Sinyuk M, Alvarado A, Caplan AI, Rich J, Gerson SL, Lathia J, et al. Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance. Cancer Research. 75: 924-9. PMID 25604264 DOI: 10.1158/0008-5472.Can-14-3225  0.451
2013 Hubert CG, Bradley RK, Ding Y, Toledo CM, Herman J, Skutt-Kakaria K, Girard EJ, Davison J, Berndt J, Corrin P, Hardcastle J, Basom R, Delrow JJ, Webb T, Pollard SM, et al. Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A. Genes & Development. 27: 1032-45. PMID 23651857 DOI: 10.1101/Gad.212548.112  0.645
2013 Ding Y, Hubert CG, Herman J, Corrin P, Toledo CM, Skutt-Kakaria K, Vazquez J, Basom R, Zhang B, Risler JK, Pollard SM, Nam DH, Delrow JJ, Zhu J, Lee J, et al. Cancer-Specific requirement for BUB1B/BUBR1 in human brain tumor isolates and genetically transformed cells. Cancer Discovery. 3: 198-211. PMID 23154965 DOI: 10.1158/2159-8290.Cd-12-0353  0.648
2013 Hubert CG, Bradley RK, Ding Y, Chad TM, Skutt-Kakaria K, Girard EJ, Davison J, Berndt J, Corrin P, Basom R, Delrow JJ, Webb T, Pollard SM, Lee J, Olson JM, et al. Abstract A20: Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-A20  0.653
2013 Ding Y, Hubert C, Herman J, DeLuca J, Olson J, Paddison P. Abstract A05: Functional genetic approach identifies cancer-specific requirement for BUB1B/BubR1 in human brain tumor isolates and genetically transformed cells Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-A05  0.653
2012 Hubert CG, Ding Y, Toledo C, Paddison PJ, Olson JM, Berndt J. Abstract 5118: A functional genetic approach in patient-derived glioblastoma stem cells reveals pre-mRNA splicing components to be cancer-lethal gene targets Cancer Research. 72: 5118-5118. DOI: 10.1158/1538-7445.Am2012-5118  0.651
2012 Leonard A, Wolff J, Sengupta R, Marassa J, Piwnica-Worms D, Rubin J, Pollack I, Jakacki R, Butterfield L, Okada H, Fangusaro J, Warren KE, Mullins C, Jurgen P, Julia S, ... ... Hubert C, et al. HIGH GRADE GLIOMAS Neuro-Oncology. 14: i56-i68. DOI: 10.1093/Neuonc/Nos102  0.383
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