Matthew Freeman
Affiliations: | MRC Laboratory of Molecular Biology, Cambridge, England, United Kingdom | ||
| University of Oxford, Oxford, United Kingdom |
Area:
cell biology, signalling, physiologyWebsite:
http://www2.mrc-lmb.cam.ac.uk/group-leaders/a-to-g/m-freemanGoogle:
"Matthew Freeman"Parents
Sign in to add mentor| David M. Glover | grad student | 1983-1987 | Imperial College |
| Gerald M. Rubin | post-doc | 1987-1992 | UC Berkeley |
Children
Sign in to add trainee| Luis M. Escudero | post-doc | Universidad de Sevilla | |
| George Angus McQuibban | post-doc | (Chemistry Tree) | |
| Kvido Stříšovský | post-doc | 2005-2011 | MRC-LMB |
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Publications
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| Grieve AG, Yeh YC, Chang YF, et al. (2021) Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation. Molecular Cell |
| Muliyil S, Levet C, Düsterhöft S, et al. (2020) ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet-mediated degeneration. The Embo Journal. e104415 |
| Liu G, Beaton SE, Grieve AG, et al. (2020) Bacterial rhomboid proteases mediate quality control of orphan membrane proteins. The Embo Journal. e102922 |
| Freeman M. (2020) Rhomboid Proteins in Cell Signaling The Faseb Journal. 34: 1-1 |
| Ikeda KN, Freeman M. (2019) Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4. The Journal of Biological Chemistry |
| Dulloo I, Muliyil S, Freeman M. (2019) The molecular, cellular and pathophysiological roles of iRhom pseudoproteases. Open Biology. 9: 190003 |
| Künzel U, Grieve AG, Meng Y, et al. (2018) FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex. Elife. 7 |
| Johnson N, Březinová J, Stephens E, et al. (2017) Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis. Scientific Reports. 7: 7283 |
| Düsterhöft S, Künzel U, Freeman M. (2017) Rhomboid proteases in human disease: Mechanisms and future prospects. Biochimica Et Biophysica Acta |
| Grieve AG, Xu H, Künzel U, et al. (2017) Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling. Elife. 6 |