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Hiroshi Hiasa - Publications

Affiliations: 
University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Pharmacology, Biochemistry
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62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Aguirre AL, Chheda PR, Lentz SRC, Held HA, Groves NP, Hiasa H, Kerns RJ. Identification of an ethyl 5,6-dihydropyrazolo[1,5-c]quinazoline-1-carboxylate as a catalytic inhibitor of DNA gyrase. Bioorganic & Medicinal Chemistry. 115439. PMID 32234278 DOI: 10.1016/J.Bmc.2020.115439  0.493
2020 Fan BZ, Hiasa H, Lv W, Brody S, Yang ZY, Aldrich C, Cushman M, Liang JH. Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. European Journal of Medicinal Chemistry. 193: 112222. PMID 32200200 DOI: 10.1016/J.Ejmech.2020.112222  0.402
2019 Delgado JL, Lentz SRC, Kulkarni CA, Chheda PR, Held HA, Hiasa H, Kerns RJ. Probing structural requirements for human topoisomerase I inhibition by a novel N1-Biphenyl fluoroquinolone. European Journal of Medicinal Chemistry. 172: 109-130. PMID 30959322 DOI: 10.1016/J.Ejmech.2019.03.040  0.386
2019 Lentz SRC, Chheda PR, Oppegard LM, Towle TR, Kerns RJ, Hiasa H. The C7-aminomethylpyrrolidine group rescues the activity of a thio-fluoroquinolone. Biochimie. 160: 24-27. PMID 30763638 DOI: 10.1016/J.Biochi.2019.02.002  0.434
2018 Ostrer L, Khodursky RF, Johnson JR, Hiasa H, Khodursky A. Analysis of Mutational Patterns in Quinolone Resistance-Determining Regions of GyrA and ParC of Clinical Isolates. International Journal of Antimicrobial Agents. PMID 30582984 DOI: 10.1016/J.Ijantimicag.2018.12.004  0.362
2018 Oppegard LM, Delgado JL, Kulkarni CA, Towle TR, Hart DE, Williams BP, Lentz SRC, Norris BJ, Flory CM, Schumacher RJ, Murry DJ, Kerns RJ, Hiasa H. Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity. Investigational New Drugs. PMID 30198058 DOI: 10.1007/S10637-018-0666-X  0.453
2018 Towle TR, Kulkarni CA, Oppegard LM, Williams BP, Picha TA, Hiasa H, Kerns RJ. Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase. Bioorganic & Medicinal Chemistry Letters. PMID 29661533 DOI: 10.1016/J.Bmcl.2018.03.085  0.433
2018 Delgado JL, Hsieh CM, Chan NL, Hiasa H. Topoisomerases as anticancer targets. The Biochemical Journal. 475: 373-398. PMID 29363591 DOI: 10.1042/Bcj20160583  0.414
2018 Hiasa H. DNA Topoisomerases as Targets for Antibacterial Agents. Methods in Molecular Biology (Clifton, N.J.). 1703: 47-62. PMID 29177732 DOI: 10.1007/978-1-4939-7459-7_3  0.452
2016 Malik M, Mustaev A, Schwanz HA, Luan G, Shah N, Oppegard LM, de Souza EC, Hiasa H, Zhao X, Kerns RJ, Drlica K. Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones. Nucleic Acids Research. PMID 26984528 DOI: 10.1093/Nar/Gkw161  0.404
2016 Oppegard LM, Schwanz HA, Towle TR, Kerns RJ, Hiasa H. Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site. Biochimica Et Biophysica Acta. 1860: 569-75. PMID 26723176 DOI: 10.1016/J.Bbagen.2015.12.019  0.45
2014 Benoit AR, Schiaffo C, Salomon CE, Goodell JR, Hiasa H, Ferguson DM. Synthesis and evaluation of N-alkyl-9-aminoacridines with antibacterial activity. Bioorganic & Medicinal Chemistry Letters. 24: 3014-7. PMID 24908610 DOI: 10.1016/J.Bmcl.2014.05.037  0.312
2014 Mustaev A, Malik M, Zhao X, Kurepina N, Luan G, Oppegard LM, Hiasa H, Marks KR, Kerns RJ, Berger JM, Drlica K. Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding. The Journal of Biological Chemistry. 289: 12300-12. PMID 24497635 DOI: 10.1074/Jbc.M113.529164  0.522
2013 Verghese J, Nguyen T, Oppegard LM, Seivert LM, Hiasa H, Ellis KC. Flavone-based analogues inspired by the natural product simocyclinone D8 as DNA gyrase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 5874-7. PMID 24060488 DOI: 10.1016/J.Bmcl.2013.08.094  0.454
2013 Gottschalk S, Ifrah D, Lerche S, Gottlieb CT, Cohn MT, Hiasa H, Hansen PR, Gram L, Ingmer H, Thomsen LE. The antimicrobial lysine-peptoid hybrid LP5 inhibits DNA replication and induces the SOS response in Staphylococcus aureus. Bmc Microbiology. 13: 192. PMID 23945181 DOI: 10.1186/1471-2180-13-192  0.384
2013 Rusman Y, Oppegard LM, Hiasa H, Gelbmann C, Salomon CE. Solphenazines A-F, glycosylated phenazines from Streptomyces sp. strain DL-93. Journal of Natural Products. 76: 91-6. PMID 23317013 DOI: 10.1021/Np3007606  0.32
2012 Oppegard LM, Nguyen T, Ellis KC, Hiasa H. Inhibition of human topoisomerases I and II by simocyclinone D8. Journal of Natural Products. 75: 1485-9. PMID 22867097 DOI: 10.1021/Np300299Y  0.348
2012 Raza A, Jacobson BA, Benoit A, Patel MR, Jay-Dixon J, Hiasa H, Ferguson DM, Kratzke RA. Novel acridine-based agents with topoisomerase II inhibitor activity suppress mesothelioma cell proliferation and induce apoptosis. Investigational New Drugs. 30: 1443-8. PMID 21789510 DOI: 10.1007/S10637-011-9720-7  0.382
2010 Oppegard LM, Streck KR, Rosen JD, Schwanz HA, Drlica K, Kerns RJ, Hiasa H. Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones. Antimicrobial Agents and Chemotherapy. 54: 3011-4. PMID 20404126 DOI: 10.1128/Aac.00190-10  0.378
2010 Giri R, Goodell JR, Xing C, Benoit A, Kaur H, Hiasa H, Ferguson DM. Synthesis and cancer cell cytotoxicity of substituted xanthenes. Bioorganic & Medicinal Chemistry. 18: 1456-63. PMID 20129790 DOI: 10.1016/J.Bmc.2010.01.018  0.341
2010 Sadiq AA, Patel MR, Jacobson BA, Escobedo M, Ellis K, Oppegard LM, Hiasa H, Kratzke RA. Anti-proliferative effects of simocyclinone D8 (SD8), a novel catalytic inhibitor of topoisomerase II. Investigational New Drugs. 28: 20-5. PMID 19132295 DOI: 10.1007/S10637-008-9209-1  0.361
2009 Drlica K, Hiasa H, Kerns R, Malik M, Mustaev A, Zhao X. Quinolones: action and resistance updated. Current Topics in Medicinal Chemistry. 9: 981-98. PMID 19747119 DOI: 10.2174/156802609789630947  0.524
2009 Gálvez-Peralta M, Hackbarth JS, Flatten KS, Kaufmann SH, Hiasa H, Xing C, Ferguson DM. On the role of topoisomerase I in mediating the cytotoxicity of 9-aminoacridine-based anticancer agents. Bioorganic & Medicinal Chemistry Letters. 19: 4459-62. PMID 19501511 DOI: 10.1016/J.Bmcl.2009.05.037  0.356
2009 Oppegard LM, Hamann BL, Streck KR, Ellis KC, Fiedler HP, Khodursky AB, Hiasa H. In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus. Antimicrobial Agents and Chemotherapy. 53: 2110-9. PMID 19273673 DOI: 10.1128/Aac.01440-08  0.364
2009 Oppegard LM, Ougolkov AV, Luchini DN, Schoon RA, Goodell JR, Kaur H, Billadeau DD, Ferguson DM, Hiasa H. Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II. European Journal of Pharmacology. 602: 223-9. PMID 19071108 DOI: 10.1016/J.Ejphar.2008.11.044  0.364
2008 Goodell JR, Ougolkov AV, Hiasa H, Kaur H, Remmel R, Billadeau DD, Ferguson DM. Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis. Journal of Medicinal Chemistry. 51: 179-82. PMID 18163538 DOI: 10.1021/Jm701228E  0.414
2007 Morgan-Linnell SK, Hiasa H, Zechiedrich L, Nitiss JL. Assessing sensitivity to antibacterial topoisomerase II inhibitors. Current Protocols in Pharmacology / Editorial Board, S.J. Enna (Editor-in-Chief) ... [Et Al.]. Unit3.13. PMID 21948169 DOI: 10.1002/0471141755.Ph0313S39  0.455
2007 Pfeiffer ES, Hiasa H. Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. Antimicrobial Agents and Chemotherapy. 51: 3410-2. PMID 17606687 DOI: 10.1128/Aac.00362-07  0.647
2007 Reckinger AR, Jeong KS, Khodursky AB, Hiasa H. RecA can stimulate the relaxation activity of topoisomerase I: Molecular basis of topoisomerase-mediated genome-wide transcriptional responses in Escherichia coli. Nucleic Acids Research. 35: 79-86. PMID 17151069 DOI: 10.1093/Nar/Gkl981  0.386
2006 Jeong KS, Xie Y, Hiasa H, Khodursky AB. Analysis of pleiotropic transcriptional profiles: a case study of DNA gyrase inhibition. Plos Genetics. 2: e152. PMID 17009874 DOI: 10.1371/Journal.Pgen.0020152  0.383
2006 Goodell JR, Madhok AA, Hiasa H, Ferguson DM. Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity. Bioorganic & Medicinal Chemistry. 14: 5467-80. PMID 16713270 DOI: 10.1016/J.Bmc.2006.04.044  0.416
2006 Li Z, Hiasa H, DiGate R. Characterization of a unique type IA topoisomerase in Bacillus cereus. Molecular Microbiology. 60: 140-51. PMID 16556226 DOI: 10.1111/J.1365-2958.2006.05070.X  0.393
2006 Kramlinger VM, Hiasa H. The "GyrA-box" is required for the ability of DNA gyrase to wrap DNA and catalyze the supercoiling reaction. The Journal of Biological Chemistry. 281: 3738-42. PMID 16332690 DOI: 10.1074/Jbc.M511160200  0.479
2005 Li Z, Hiasa H, DiGate R. Bacillus cereus DNA topoisomerase I and IIIalpha: purification, characterization and complementation of Escherichia coli TopoIII activity. Nucleic Acids Research. 33: 5415-25. PMID 16192570 DOI: 10.1093/Nar/Gki846  0.492
2004 Pfeiffer ES, Hiasa H. Replacement of ParC alpha4 helix with that of GyrA increases the stability and cytotoxicity of topoisomerase IV-quinolone-DNA ternary complexes. Antimicrobial Agents and Chemotherapy. 48: 608-11. PMID 14742217 DOI: 10.1128/Aac.48.2.608-611.2004  0.667
2003 Shea ME, Hiasa H. The RuvAB branch migration complex can displace topoisomerase IV.quinolone.DNA ternary complexes. The Journal of Biological Chemistry. 278: 48485-90. PMID 13679378 DOI: 10.1074/Jbc.M304217200  0.483
2003 Hiasa H, Shea ME, Richardson CM, Gwynn MN. Staphylococcus aureus gyrase-quinolone-DNA ternary complexes fail to arrest replication fork progression in vitro. Effects of salt on the DNA binding mode and the catalytic activity of S. aureus gyrase. The Journal of Biological Chemistry. 278: 8861-8. PMID 12511566 DOI: 10.1074/Jbc.M209207200  0.48
2002 Hiasa H. The Glu-84 of the ParC subunit plays critical roles in both topoisomerase IV-quinolone and topoisomerase IV-DNA interactions. Biochemistry. 41: 11779-85. PMID 12269820 DOI: 10.1021/Bi026352V  0.445
2001 Lavasani LS, Hiasa H. A ParE-ParC fusion protein is a functional topoisomerase. Biochemistry. 40: 8438-43. PMID 11456480 DOI: 10.1021/Bi0155201  0.41
2001 Shea ME, Hiasa H. Replicative helicases can translocate through abasic site-induced covalent topoisomerase IV-DNA complexes. Nucleic Acids Research. 29: 614-21. PMID 11160881 DOI: 10.1093/Nar/29.3.614  0.485
2000 Hiasa H, Shea ME. DNA gyrase-mediated wrapping of the DNA strand is required for the replication fork arrest by the DNA gyrase-quinolone-DNA ternary complex. The Journal of Biological Chemistry. 275: 34780-6. PMID 11053451 DOI: 10.1074/Jbc.M001608200  0.49
2000 Shea ME, Hiasa H. Distinct effects of the UvrD helicase on topoisomerase-quinolone-DNA ternary complexes. The Journal of Biological Chemistry. 275: 14649-58. PMID 10799552 DOI: 10.1074/Jbc.275.19.14649  0.5
2000 Li Z, Mondragón A, Hiasa H, Marians KJ, DiGate RJ. Identification of a unique domain essential for Escherichia coli DNA topoisomerase III-catalysed decatenation of replication intermediates. Molecular Microbiology. 35: 888-95. PMID 10692165 DOI: 10.1046/J.1365-2958.2000.01763.X  0.475
1999 Hiasa H, Marians KJ. Initiation of bidirectional replication at the chromosomal origin is directed by the interaction between helicase and primase Journal of Biological Chemistry. 274: 27244-27248. PMID 10480943 DOI: 10.1074/Jbc.274.38.27244  0.388
1999 Shea ME, Hiasa H. Interactions between DNA helicases and frozen topoisomerase IV-quinolone-DNA ternary complexes. The Journal of Biological Chemistry. 274: 22747-54. PMID 10428858 DOI: 10.1074/Jbc.274.32.22747  0.494
1998 Peter BJ, Ullsperger C, Hiasa H, Marians KJ, Cozzarelli NR. The structure of supercoiled intermediates in DNA replication. Cell. 94: 819-27. PMID 9753328 DOI: 10.1016/S0092-8674(00)81740-7  0.452
1998 Levine C, Hiasa H, Marians KJ. DNA gyrase and topoisomerase IV: biochemical activities, physiological roles during chromosome replication, and drug sensitivities. Biochimica Et Biophysica Acta. 1400: 29-43. PMID 9748489 DOI: 10.1016/S0167-4781(98)00126-2  0.444
1998 Marians KJ, Hiasa H, Kim DR, McHenry CS. Role of the core DNA polymerase III subunits at the replication fork. Alpha is the only subunit required for processive replication. The Journal of Biological Chemistry. 273: 2452-7. PMID 9442096 DOI: 10.1074/Jbc.273.4.2452  0.412
1997 Li Z, Hiasa H, Kumar U, DiGate RJ. The traE gene of plasmid RP4 encodes a homologue of Escherichia coli DNA topoisomerase III. The Journal of Biological Chemistry. 272: 19582-7. PMID 9235964 DOI: 10.1074/Jbc.272.31.19582  0.432
1997 Marians KJ, Hiasa H. Mechanism of quinolone action. A drug-induced structural perturbation of the DNA precedes strand cleavage by topoisomerase IV Journal of Biological Chemistry. 272: 9401-9409. PMID 9083078 DOI: 10.1074/Jbc.272.14.9401  0.515
1996 Hiasa H, Yousef DO, Marians KJ. DNA strand cleavage is required for replication fork arrest by a frozen topoisomerase-quinolone-DNA ternary complex Journal of Biological Chemistry. 271: 26424-26429. PMID 8824300 DOI: 10.1074/Jbc.271.42.26424  0.53
1996 Hiasa H, Marians KJ. Two distinct modes of strand unlinking during θ-type DNA replication Journal of Biological Chemistry. 271: 21529-21535. PMID 8702938 DOI: 10.1074/Jbc.271.35.21529  0.456
1996 Zhang HL, Malpure S, Li Z, Hiasa H, DiGate RJ. The role of the carboxyl-terminal amino acid residues in Escherichia coli DNA topoisomerase III-mediated catalysis. The Journal of Biological Chemistry. 271: 9039-45. PMID 8621552 DOI: 10.1074/Jbc.271.15.9039  0.428
1995 Skokotas A, Hiasa H, Marians KJ, O'Donnell L, Hill TM. Mutations in the Escherichia coli Tus protein define a domain positioned close to the DNA in the Tus-Ter complex. The Journal of Biological Chemistry. 270: 30941-8. PMID 8537350 DOI: 10.1074/Jbc.270.52.30941  0.494
1994 Tanaka K, Rogi T, Hiasa H, Miao D, Honda Y, Nomura N, Sakai H, Komano T. Comparative analysis of functional and structural features in the primase-dependent priming signals, G sites, from phages and plasmids. Journal of Bacteriology. 176: 3606-3613. PMID 8206839 DOI: 10.1128/Jb.176.12.3606-3613.1994  0.307
1992 Ueda K, Hiasa H, Takebe S, Sakai H, Komano T. Alternative secondary structures in the phage G4 origin of the complementary DNA strand synthesis: effects of NaCl concentration on the bleomycin-DNA interaction. Bioscience, Biotechnology, and Biochemistry. 56: 394-398. PMID 1378328 DOI: 10.1271/Bbb.56.394  0.461
1991 Honda Y, Sakai H, Hiasa H, Tanaka K, Komano T, Bagdasarian M. Functional division and reconstruction of a plasmid replication origin: Molecular dissection of the oriV of the broad-host-range plasmid RSF1010 Proceedings of the National Academy of Sciences of the United States of America. 88: 179-183. PMID 1986363 DOI: 10.1073/Pnas.88.1.179  0.414
1991 Tanaka K, Sakai T, Honda Y, Hiasa H, Sakai H, Komano T. Plasmid colIb contains an ssi signal close to the replication origin Plasmid. 25: 125-130. PMID 1857752 DOI: 10.1016/0147-619X(91)90024-Q  0.384
1990 Hiasa H, Sakai H, Komano T, Godson GN. Structural features of the priming signal recognized by primase: mutational analysis of the phage G4 origin of complementary DNA strand synthesis Nucleic Acids Research. 18: 4825-4831. PMID 1697677 DOI: 10.1093/Nar/18.16.4825  0.391
1989 Hiasa H, Tanaka K, Sakai H, Yoshida K, Honda Y, Komano T, Godson GN. Distinct functional contributions of three potential secondary structures in the phage G4 origin of complementary DNA strand synthesis. Gene. 84: 17-22. PMID 2691335 DOI: 10.1016/0378-1119(89)90134-0  0.367
1989 Hiasa H, Sakai H, Tanaka K, Honda Y, Komano T, Godson GN. Mutational analysis of the primer RNA template region in the replication origin (oric) of bacteriophage G4: priming signal recognition by Escherichia coli primase. Gene. 84: 9-16. PMID 2558060 DOI: 10.1016/0378-1119(89)90133-9  0.331
1989 Hiasa H, Sakai H, Komano T. Identification of single-strand initiation signals in the terC region of the Escherichia coli chromosome. Febs Letters. 246: 21-24. PMID 2540037 DOI: 10.1016/0014-5793(89)80245-5  0.35
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