Matthew D. Scharff
Affiliations: | Cell Biology | Albert Einstein College of Medicine, New York, New York, United States |
Area:
molecular and biochemical mechanisms of antibody variable region hypermutation and class switch recombinationWebsite:
http://www.einstein.yu.edu/faculty/1450/matthew-scharff/Google:
"Matthew D. Scharff"Bio:
http://www.einstein.yu.edu/departments/cell-biology/faculty/matthew-scharff/research.aspx
http://www.einstein.yu.edu/departments/cell-biology/faculty/matthew-scharff/biosketch.aspx
Cross-listing: Cell Biology Tree - Chemistry Tree
Parents
Sign in to add mentor| Leon Levintow | post-doc | 1961-1963 | National Institutes of Health, National Institute of Allergy and Infectious Diseases (FlyTree) |
Children
Sign in to add trainee| Donald J. Zack | grad student | 1977-1984 | Albert Einstein (Neurotree) |
| Samuel M. Behar | grad student | 1983-1988 | Albert Einstein (Microtree) |
| Valadon Philippe | post-doc | (Chemistry Tree) | |
| Barbara K. Birshtein | post-doc | 1971-1973 | Albert Einstein (Cell Biology Tree) |
| Ronald A. DePinho | post-doc | 1984-1985 | Albert Einstein (Telomere and Telomerase Tree) |
| Alberto Martin | research scientist | 2000-2003 | Albert Einstein (Cell Biology Tree) |
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Publications
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| Duan Z, Baughn LB, Wang X, et al. (2021) Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes. Proceedings of the National Academy of Sciences of the United States of America. 118 |
| Tang C, Bagnara D, Chiorazzi N, et al. (2020) AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes. Frontiers in Immunology. 11: 788 |
| Bartholdy BA, Wang X, Yan XJ, et al. (2020) CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation. Blood Advances. 4: 893-905 |
| Wang X, Duan Z, Yu G, et al. (2018) Human Immunodeficiency Virus Tat Protein Aids V Region Somatic Hypermutation in Human B Cells. Mbio. 9 |
| Wei L, Chahwan R, Wang S, et al. (2015) Overlapping hotspots in CDRs are critical sites for V region diversification. Proceedings of the National Academy of Sciences of the United States of America. 112: E728-37 |
| Varshney AK, Wang X, Aguilar JL, et al. (2014) Isotype switching increases efficacy of antibody protection against staphylococcal enterotoxin B-induced lethal shock and Staphylococcus aureus sepsis in mice. Mbio. 5: e01007-14 |
| Varshney AK, Wang X, Cook E, et al. (2014) Erratum: Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against Staphylococcal enterotoxin B-induced lethal shock (Journal of Biological Chemistry (2011) 286 (9737-9747)) Journal of Biological Chemistry. 289 |
| Schaetzlein S, Chahwan R, Avdievich E, et al. (2013) Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes. Proceedings of the National Academy of Sciences of the United States of America. 110: E2470-9 |
| Jaszczur M, Bertram JG, Pham P, et al. (2013) AID and Apobec3G haphazard deamination and mutational diversity. Cellular and Molecular Life Sciences : Cmls. 70: 3089-108 |
| Patten PE, Chu CC, Albesiano E, et al. (2012) IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions. Blood. 120: 4802-11 |