Jessica H. Brehm, Ph.D.
Affiliations: | 2010 | University of Pittsburgh, Pittsburgh, PA, United States |
Area:
Virology Biology, Biochemistry, GeneticsGoogle:
"Jessica Brehm"Parents
Sign in to add mentor| John W. Mellors | grad student | 2010 | University of Pittsburgh | |
| (Novel mechanisms of resistance to HIV-1 reverse transcriptase (RT) inhibitors: a molecular and clinical characterization of mutations in the connection and RNase H domains of RT.) | ||||
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Publications
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| Okoye AA, Fromentin R, Takata H, et al. (2022) The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription. Plos Pathogens. 18: e1010245 |
| Nixon CC, Mavigner M, Sampey GC, et al. (2020) Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo. Nature |
| Gavegnano C, Brehm JH, Dupuy FP, et al. (2017) Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors. Plos Pathogens. 13: e1006740 |
| Procopio FA, Fromentin R, Kulpa DA, et al. (2015) A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals Ebiomedicine |
| Brehm JH, Koontz DL, Wallis CL, et al. (2012) Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 55: 737-45 |
| Brehm JH, Scott Y, Koontz DL, et al. (2012) Zidovudine (AZT) monotherapy selects for the A360V mutation in the connection domain of HIV-1 reverse transcriptase. Plos One. 7: e31558 |
| Brehm JH, Lalama CM, Hughes MD, et al. (2011) Failure of initial therapy with two nucleosides and efavirenz is not associated with early emergence of mutations in the C-terminus of HIV-1 reverse transcriptase. Journal of Acquired Immune Deficiency Syndromes (1999). 56: 344-8 |
| Brehm JH, Mellors JW, Sluis-Cremer N. (2008) Mechanism by which a glutamine to leucine substitution at residue 509 in the ribonuclease H domain of HIV-1 reverse transcriptase confers zidovudine resistance. Biochemistry. 47: 14020-7 |
| Brehm JH, Koontz D, Meteer JD, et al. (2007) Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine. Journal of Virology. 81: 7852-9 |