Kalen R. Dionne, Ph.D.

Affiliations: 
2012 University of Colorado Anschutz Medical Campus, Denver, Aurora, CO 
Area:
Neuroscience Biology, Virology Biology, Immunology
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"Kalen Dionne"

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Kenneth L. Tyler grad student 2012 University of Colorado, Denver
 (Modeling reovirus encephalitis in brain slice cultures for investigation of CNS-specific antiviral immunity: Cytokine production, interferon signaling, and induction of interferon stimulated genes (PML and DAXX).)
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Publications

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Dionne KR, Tyler KL, Clarke P. (2021) Slice Culture Modeling of CNS Viral Infection. Methods in Molecular Biology (Clifton, N.J.). 2311: 109-130
Clarke P, Leser JS, Quick ED, et al. (2014) Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response. Journal of Virology. 88: 1080-9
Dionne KR, Tyler KL. (2013) Slice culture modeling of central nervous system (CNS) viral infection. Methods in Molecular Biology (Clifton, N.J.). 1078: 97-117
Dionne KR, Zhuang Y, Leser JS, et al. (2013) Daxx upregulation within the cytoplasm of reovirus-infected cells is mediated by interferon and contributes to apoptosis. Journal of Virology. 87: 3447-60
Schittone SA, Dionne KR, Tyler KL, et al. (2012) Activation of innate immune responses in the central nervous system during reovirus myelitis. Journal of Virology. 86: 8107-18
Dionne KR, Galvin JM, Schittone SA, et al. (2011) Type I interferon signaling limits reoviral tropism within the brain and prevents lethal systemic infection. Journal of Neurovirology. 17: 314-26
Dionne KR, Leser JS, Lorenzen KA, et al. (2011) A brain slice culture model of viral encephalitis reveals an innate CNS cytokine response profile and the therapeutic potential of caspase inhibition. Experimental Neurology. 228: 222-31
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