Timothy G. Alefantis, Ph.D.

Affiliations: 
2003 Pennsylvania State University, State College, PA, United States 
Area:
Microbiology Biology, Immunology, Cell Biology
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"Timothy Alefantis"

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Brian Wigdahl grad student 2003 Penn State
 (Analysis of amino acid signals within the human T cell leukemia virus type I transactivator protein Tax that control nuclear export, cytoplasmic intracellular localization, and secretion.)
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Publications

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Jain P, Mostoller K, Flaig KE, et al. (2007) Identification of human T cell leukemia virus type 1 tax amino acid signals and cellular factors involved in secretion of the viral oncoprotein. The Journal of Biological Chemistry. 282: 34581-93
Alefantis T, Flaig KE, Wigdahl B, et al. (2007) Interaction of HTLV-1 Tax protein with calreticulin: implications for Tax nuclear export and secretion. Biomedicine & Pharmacotherapy = BioméDecine & PharmacothéRapie. 61: 194-200
Grant C, Jain P, Nonnemacher M, et al. (2006) AP-1-directed human T cell leukemia virus type 1 viral gene expression during monocytic differentiation. Journal of Leukocyte Biology. 80: 640-50
Yao J, Grant C, Harhaj E, et al. (2006) Regulation of human T-cell leukemia virus type 1 gene expression by Sp1 and Sp3 interaction with TRE-1 repeat III. Dna and Cell Biology. 25: 262-76
Alefantis T, Jain P, Ahuja J, et al. (2005) HTLV-1 Tax nucleocytoplasmic shuttling, interaction with the secretory pathway, extracellular signaling, and implications for neurologic disease. Journal of Biomedical Science. 12: 961-74
Harhaj EW, Harhaj NS, Grant C, et al. (2005) Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway. Virology. 333: 145-58
Alefantis T, Mostoller K, Jain P, et al. (2005) Secretion of the human T cell leukemia virus type I transactivator protein tax. The Journal of Biological Chemistry. 280: 17353-62
Barmak K, Harhaj E, Grant C, et al. (2003) Human T cell leukemia virus type I-induced disease: pathways to cancer and neurodegeneration. Virology. 308: 1-12
Alefantis T, Barmak K, Harhaj EW, et al. (2003) Characterization of a nuclear export signal within the human T cell leukemia virus type I transactivator protein Tax. The Journal of Biological Chemistry. 278: 21814-22
Grant C, Barmak K, Alefantis T, et al. (2002) Human T cell leukemia virus type I and neurologic disease: events in bone marrow, peripheral blood, and central nervous system during normal immune surveillance and neuroinflammation. Journal of Cellular Physiology. 190: 133-59
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