Sepideh Afshar, Ph.D.
Affiliations: | 2009 | University of California, Los Angeles, Los Angeles, CA |
Area:
Immunology, Biochemistry, Pharmaceutical ChemistryGoogle:
"Sepideh Afshar"Parents
Sign in to add mentorSherie L. Morrison | grad student | 2009 | UCLA | |
(Engineering an all human component Antibody Enzyme Prodrug Therapy (ADEPT) to overcome its current clinical limitations.) |
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Publications
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Afshar S, Olafsen T, Wu AM, et al. (2009) Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT. Journal of Experimental & Clinical Cancer Research : Cr. 28: 147 |
Afshar S, Sawaya MR, Morrison SL. (2009) Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2'-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine. Protein Science : a Publication of the Protein Society. 18: 1107-14 |
Afshar S, Asai T, Morrison SL. (2009) Humanized ADEPT comprised of an engineered human purine nucleoside phosphorylase and a tumor targeting peptide for treatment of cancer. Molecular Cancer Therapeutics. 8: 185-93 |
Afshar S, Johnson E, de Vries S, et al. (2001) Properties of a thermostable nitrate reductase from the hyperthermophilic archaeon Pyrobaculum aerophilum. Journal of Bacteriology. 183: 5491-5 |