Corinne K. Cusumano, Ph.D.
Affiliations: | 2009 | Biology & Biomedical Sciences (Molecular Microbiology & Microbial Pathogenesis) | Washington University, Saint Louis, St. Louis, MO |
Area:
Microbiology Biology, PathologyGoogle:
"Corinne Cusumano"Parents
Sign in to add mentor| Scott J. Hultgren | grad student | 2009 | Washington University | |
| (Uropathogenic Escherichia coli employ a conserved intracellular infection pathway that can be inhibited by novel anti-virulence therapeutics.) | ||||
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| Jarvis C, Han Z, Kalas V, et al. (2016) Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI. Chemmedchem |
| Jarvis C, Han Z, Kalas V, et al. (2016) Cover Picture: Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI (ChemMedChem 4/2016) Chemmedchem. 11: 351-351 |
| Guiton PS, Cusumano CK, Kline KA, et al. (2012) Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice. Antimicrobial Agents and Chemotherapy. 56: 4738-45 |
| Kostakioti M, Hadjifrangiskou M, Cusumano CK, et al. (2012) Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection Infection and Immunity. 80: 2826-2834 |
| Han Z, Pinkner JS, Ford B, et al. (2012) Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides. Journal of Medicinal Chemistry. 55: 3945-59 |
| Chorell E, Pinkner JS, Bengtsson C, et al. (2012) Design and synthesis of fluorescent pilicides and curlicides: bioactive tools to study bacterial virulence mechanisms. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 4522-32 |
| Cusumano CK, Pinkner JS, Han Z, et al. (2011) Treatment and prevention of urinary tract infection with orally active FimH inhibitors. Science Translational Medicine. 3: 109ra115 |
| Han Z, Pinkner JS, Ford B, et al. (2010) Structure-based drug design and optimization of mannoside bacterial FimH antagonists. Journal of Medicinal Chemistry. 53: 4779-92 |
| Cusumano CK, Hung CS, Chen SL, et al. (2010) Virulence plasmid harbored by uropathogenic Escherichia coli functions in acute stages of pathogenesis. Infection and Immunity. 78: 1457-67 |
| Chen SL, Hung CS, Pinkner JS, et al. (2009) Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding. Proceedings of the National Academy of Sciences of the United States of America. 106: 22439-44 |