Brad E. Hoffman, Ph.D.
Affiliations: | 2006 | Temple University, Philadelphia, PA, United States |
Area:
Immunology, Animal Physiology BiologyGoogle:
"Brad Hoffman"Parents
Sign in to add mentor| Chris D. Platsoucas | grad student | 2006 | Temple University | |
| (Apoptosis and survival of T-cells infiltrating the CNS of Theiler's murine encephalomyelitis virus infected mice.) | ||||
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Publications
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| Gaddie CD, Senior KG, Chan C, et al. (2024) Upregulation of CD8 regulatory T cells following liver-directed AAV gene therapy. Cellular Immunology. 104806 |
| Keeler GD, Gaddie CD, Sagadevan AS, et al. (2022) Induction of antigen-specific tolerance by hepatic AAV immunotherapy regardless of T cell epitope usage or mouse strain background. Molecular Therapy. Methods & Clinical Development. 28: 177-189 |
| Yang H, Qing K, Keeler GD, et al. (2020) Enhanced Transduction of Human Hematopoietic Stem Cells by AAV6 Vectors: Implications in Gene Therapy and Genome Editing. Molecular Therapy. Nucleic Acids. 20: 451-458 |
| Yin L, Keeler GD, Zhang Y, et al. (2020) AAV3-miRNA vectors for growth suppression of human hepatocellular carcinoma cells in vitro and human liver tumors in a murine xenograft model in vivo. Gene Therapy |
| Shirley JL, Keeler GD, Sherman A, et al. (2019) Type I IFN Sensing by cDCs and CD4 T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8 T Cells. Molecular Therapy : the Journal of the American Society of Gene Therapy |
| Keeler GD, Markusic DM, Hoffman BE. (2017) Liver induced transgene tolerance with AAV vectors. Cellular Immunology |
| Keeler GD, Kumar S, Palaschak B, et al. (2017) Gene Therapy-Induced Antigen-Specific Tregs Inhibit Neuro-inflammation and Reverse Disease in a Mouse Model of Multiple Sclerosis. Molecular Therapy : the Journal of the American Society of Gene Therapy |
| Herzog RW, Cooper M, Perrin GQ, et al. (2017) Regulatory T cells and TLR9 activation shape antibody formation to a secreted transgene product in AAV muscle gene transfer. Cellular Immunology |
| Rogers GL, Shirley JL, Zolotukhin I, et al. (2017) Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8(+) T cells. Blood. 129: 3184-3195 |
| Kumar SR, Hoffman BE, Terhorst C, et al. (2017) The Balance between CD8(+) T Cell-Mediated Clearance of AAV-Encoded Antigen in the Liver and Tolerance Is Dependent on the Vector Dose. Molecular Therapy : the Journal of the American Society of Gene Therapy. 25: 880-891 |