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Paul Spear, Ph.D.

Affiliations: 
2013 Immunology and Microbiology Dartmouth College, Hanover, NH, United States 
Area:
Immunology, Microbiology Biology, General
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Charles L. Sentman grad student 2013 Dartmouth
 (Endogenous Leukocyte Activation by Chimeric Antigen Receptor T cell Immunotherapy.)

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Publications

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Spear P, Barber A, Rynda-Apple A, et al. (2014) Correction: Chimeric Antigen Receptor T Cells Shape Myeloid Cell Function within the Tumor Microenvironment through IFN-γ and GM-CSF The Journal of Immunology. 193: 1513.4-1513
Spear P, Wu MR, Sentman ML, et al. (2013) NKG2D ligands as therapeutic targets. Cancer Immunity. 13: 8
Spear P, Barber A, Sentman CL. (2013) Collaboration of chimeric antigen receptor (CAR)-expressing T cells and host T cells for optimal elimination of established ovarian tumors. Oncoimmunology. 2: e23564
Spear P, Barber A, Rynda-Apple A, et al. (2013) NKG2D CAR T-cell therapy inhibits the growth of NKG2D ligand heterogeneous tumors. Immunology and Cell Biology. 91: 435-40
Spear P, Barber A, Rynda-Apple A, et al. (2012) Chimeric antigen receptor T cells shape myeloid cell function within the tumor microenvironment through IFN-γ and GM-CSF. Journal of Immunology (Baltimore, Md. : 1950). 188: 6389-98
Yoon M, Kopp SJ, Taylor JM, et al. (2011) Functional interaction between herpes simplex virus type 2 gD and HVEM transiently dampens local chemokine production after murine mucosal infection. Plos One. 6: e16122
Cheung TC, Oborne LM, Steinberg MW, et al. (2009) T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment. Journal of Immunology (Baltimore, Md. : 1950). 183: 7286-96
Aubert M, Yoon M, Sloan DD, et al. (2009) The virological synapse facilitates herpes simplex virus entry into T cells. Journal of Virology. 83: 6171-83
Cheung TC, Steinberg MW, Oborne LM, et al. (2009) Unconventional ligand activation of herpesvirus entry mediator signals cell survival. Proceedings of the National Academy of Sciences of the United States of America. 106: 6244-9
Sloan DD, Han JY, Sandifer TK, et al. (2006) Inhibition of TCR signaling by herpes simplex virus. Journal of Immunology (Baltimore, Md. : 1950). 176: 1825-33
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