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Mark I. Manzano, Ph.D.

Affiliations: 
2011 Microbiology & Immunology Georgetown University, Washington, DC 
Area:
Virology Biology, Microbiology Biology, Biochemistry
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"Mark Manzano"
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Radhakrishnan Padmanabhan grad student 2011 Georgetown
 (Identification of cis-acting elements in the 3'-untranslated region of the dengue virus type 2 RNA that modulate translation and replication.)

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Publications

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Manzano M, Günther T, Ju H, et al. (2020) Kaposi's Sarcoma-Associated Herpesvirus Drives a Super-Enhancer-Mediated Survival Gene Expression Program in Primary Effusion Lymphoma. Mbio. 11
Patil A, Manzano M, Gottwein E. (2019) Genome-wide CRISPR screens reveal genetic mediators of cereblon modulator toxicity in primary effusion lymphoma Blood Advances. 3: 2105-2117
Manzano M, Patil A, Waldrop A, et al. (2018) Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma. Nature Communications. 9: 3263
Patil A, Manzano M, Gottwein E. (2018) CK1α and IRF4 are essential and independent effectors of immunomodulatory drugs in primary effusion lymphoma Blood. 132: 577-586
Balasubramanian A, Manzano M, Teramoto T, et al. (2016) High-throughput screening for the identification of small-molecule inhibitors of the flaviviral protease. Antiviral Research
Zhang W, Nandakumar N, Shi Y, et al. (2014) Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma. Science Signaling. 7: ra42
Manzano M, Padia J, Padmanabhan R. (2014) Small molecule inhibitor discovery for dengue virus protease using high-throughput screening. Methods in Molecular Biology (Clifton, N.J.). 1138: 331-44
Manzano M, Padmanabhan R. (2014) Targeted mutagenesis of dengue virus type 2 replicon RNA by yeast in vivo recombination. Methods in Molecular Biology (Clifton, N.J.). 1138: 151-60
Boonyasuppayakorn S, Reichert ED, Manzano M, et al. (2014) Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity. Antiviral Research. 106: 125-34
Teramoto T, Chiang HS, Takhampunya R, et al. (2013) Gamma interferon-inducible lysosomal thioreductase (GILT) ablation renders mouse fibroblasts sensitive to dengue virus replication. Virology. 441: 146-51
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