Joel J. Bruegger, Ph.D.

Affiliations: 
2013 Biological Sciences University of California, Irvine, Irvine, CA 
Area:
Biochemistry
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"Joel Bruegger"

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Shiou-Chuan Tsai grad student 2013 UC Irvine
 (Pantetheine Analogues Reveal Novel Characteristics in Polyketide Synthase Protein-Protein and Protein-Substrate Interactions.)
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Publications

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Kahn-Kirby AH, Amagata A, Maeder CI, et al. (2019) Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy. Plos One. 14: e0214250
Hespen CW, Bruegger JJ, Guo Y, et al. (2018) Native alanine substitution in the glycine hinge modulates conformational flexibility of Heme Nitric oxide/Oxygen (H-NOX) sensing proteins. Acs Chemical Biology
Bruegger JJ, Smith BC, Wynia-Smith SL, et al. (2018) Comparative and integrative metabolomics reveal that S-nitrosation inhibits physiologically relevant metabolic enzymes. The Journal of Biological Chemistry
Hespen CW, Bruegger JJ, Phillips-Piro CM, et al. (2016) Structural and Functional Evidence Indicates Selective Oxygen Signaling in Caldanaerobacter subterraneus H-NOX. Acs Chemical Biology
Shakya G, Rivera H, Lee DJ, et al. (2014) Modeling linear and cyclic PKS intermediates through atom replacement. Journal of the American Chemical Society. 136: 16792-9
Nguyen C, Haushalter RW, Lee DJ, et al. (2014) Trapping the dynamic acyl carrier protein in fatty acid biosynthesis. Nature. 505: 427-31
Javidpour P, Bruegger J, Srithahan S, et al. (2013) The determinants of activity and specificity in actinorhodin type II polyketide ketoreductase. Chemistry & Biology. 20: 1225-34
Bruegger J, Haushalter RW, Haushalter B, et al. (2013) Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers. Chemistry & Biology. 20: 1135-46
Ames BD, Nguyen C, Bruegger J, et al. (2012) Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 109: 11144-9
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