David F. Bruhn, Ph.D.
Affiliations: | 2011 | Molecular & Cellular Biology | University of Massachusetts, Amherst, Amherst, MA |
Area:
Molecular Biology, Parasitology Biology, GeneticsGoogle:
"David Bruhn"Parents
Sign in to add mentor| Michele M. Klingbeil | grad student | 2011 | U Mass Amherst | |
| (Mitochondrial DNA polymerase IB: Functional characterization of a putative drug target for African sleeping sickness.) | ||||
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Publications
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| Liu J, Bruhn DF, Lee RB, et al. (2017) Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions. Acs Infectious Diseases. 3: 72-88 |
| Lin H, Bruhn DF, Maddox MM, et al. (2016) Synthesis and antibacterial evaluation of macrocyclic diarylheptanoid derivatives. Bioorganic & Medicinal Chemistry Letters |
| Rakesh, Bruhn DF, Scherman MS, et al. (2015) Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids. Bioorganic & Medicinal Chemistry Letters |
| Bruhn DF, Scherman MS, Liu J, et al. (2015) In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics. Scientific Reports. 5: 13985 |
| Bruhn DF, Waidyarachchi SL, Madhura DB, et al. (2015) Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections. Science Translational Medicine. 7: 288ra75 |
| Lee RE, Hurdle JG, Liu J, et al. (2014) Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux. Nature Medicine. 20: 152-8 |
| North EJ, Scherman MS, Bruhn DF, et al. (2013) Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties. Bioorganic & Medicinal Chemistry. 21: 2587-99 |
| Rakesh, Bruhn D, Madhura DB, et al. (2012) Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties. Bioorganic & Medicinal Chemistry. 20: 6063-72 |
| Bruhn DF, Sammartino MP, Klingbeil MM. (2011) Three mitochondrial DNA polymerases are essential for kinetoplast DNA replication and survival of bloodstream form Trypanosoma brucei. Eukaryotic Cell. 10: 734-43 |
| Springer AL, Bruhn DF, Kinzel KW, et al. (2011) Silencing of a putative inner arm dynein heavy chain results in flagellar immotility in Trypanosoma brucei. Molecular and Biochemical Parasitology. 175: 68-75 |