Melanie Mediavilla-Varela, Ph.D.
Affiliations: | 2009 | Loma Linda University, Loma Linda, United States |
Area:
Microbiology Biology, Genetics, Cell BiologyGoogle:
"Melanie Mediavilla-Varela"Parents
Sign in to add mentor| Carlos A. Casiano | grad student | 2009 | Loma Linda University | |
| (Contribution of LEDGF/p75 to prostate cancer chemoresistance.) | ||||
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Publications
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| Maharaj K, Powers JJ, Mediavilla-Varela M, et al. (2020) HDAC6 Inhibition Alleviates CLL-Induced T-Cell Dysfunction and Enhances Immune Checkpoint Blockade Efficacy in the Eμ-TCL1 Model. Frontiers in Immunology. 11: 590072 |
| Maharaj K, Powers JJ, Achille A, et al. (2020) The dual PI3Kδ/CK1ε inhibitor umbralisib exhibits unique immunomodulatory effects on CLL T cells. Blood Advances. 4: 3072-3084 |
| Mediavilla-Varela M, Agrawal V, Page MM, et al. (2019) Abstract 34: A high-content imaging platform for quantitative assessment of immunogenic tumor cell killing and T-cell proliferation in 3D tumoroids of fresh patient tumor samples Cancer Research. 79: 34-34 |
| Agrawal V, Mediavilla-Varela M, Page MM, et al. (2019) Abstract 42: The importance of intact tumor immune microenvironment in unpropagated 3D fresh patient tumoroids in immuno-oncology drug testing for immunogenic tumor cell death and T-cell activation Cancer Research. 79: 42-42 |
| Gray JE, Chiappori A, Williams CC, et al. (2018) A phase I/randomized phase II study of GM.CD40L vaccine in combination with CCL21 in patients with advanced lung adenocarcinoma. Cancer Immunology, Immunotherapy : Cii |
| Mediavilla-Varela M, Page MM, Kreahling J, et al. (2018) Abstract 1020: Characterization of the immune landscape and analysis of tumor response after anti-PD-1 blockade in a 3Dex vivosystem of non-small lung cancer Tumor Biology |
| Mediavilla-Varela M, Castro J, Chiappori A, et al. (2017) A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte Activity in the Context of the Tumor Microenvironment. Neoplasia (New York, N.Y.). 19: 530-536 |
| Mediavilla-Varela M, Page MM, Kreahling J, et al. (2017) Effect of bavituximab in combination with nivolumab on tumor immune response in a 3D ex vivo system of lung cancer patients. Journal of Clinical Oncology. 35: e23091-e23091 |
| Mediavilla-Varela M, Page MM, Kreahling J, et al. (2017) Anti-PD1 treatment to induce M1 polarization of tumor infiltrating macrophages in a 3D ex vivo system of lung cancer patients. Journal of Clinical Oncology. 35: e23090-e23090 |
| Mediavilla-Varela M, Boateng K, Noyes D, et al. (2016) The anti-fibrotic agent pirfenidone synergizes with cisplatin in killing tumor cells and cancer-associated fibroblasts. Bmc Cancer. 16: 176 |