Jared D. Pitts, Ph.D.
Affiliations: | 2014 | Molecular Microbiology | Sackler School of Graduate Biomedical Sciences (Tufts University) |
Area:
Microbiology Biology, Virology BiologyGoogle:
"Jared Pitts"Parents
Sign in to add mentor| Ekaterina Heldwein | grad student | 2014 | Sackler School of Graduate Biomedical Sciences (Tufts University) | |
| (Biochemical and Structural Characterization of Proteins of the Herpesvirus Inner Tegument.) | ||||
| Priscilla L. Yang | post-doc | Harvard (Chemistry Tree) | ||
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Publications
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| Mackman RL, Kalla RV, Babusis D, et al. (2023) Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys. Journal of Medicinal Chemistry |
| Pitts J, Li J, Perry JK, et al. (2022) Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants. Antimicrobial Agents and Chemotherapy. e0022222 |
| Vermillion MS, Murakami E, Ma B, et al. (2021) Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection. Science Translational Medicine. eabl828 |
| Mackman RL, Hui HC, Perron M, et al. (2021) Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine -Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV. Journal of Medicinal Chemistry |
| Koenigsberg AL, Pitts JD, Heldwein EE. (2020) Identification of Buffer Conditions for Optimal Thermostability and Solubility of Herpesviral Protein UL37 Using the Thermofluor Assay. Bio-Protocol. 10: e3662 |
| Pruijssers AJ, George AS, Schäfer A, et al. (2020) Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice. Cell Reports. 107940 |
| Pruijssers AJ, George AS, Schäfer A, et al. (2020) Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice. Biorxiv : the Preprint Server For Biology |
| Pitts J, Hsia CY, Lian W, et al. (2019) Identification of small molecule inhibitors targeting the Zika virus envelope protein. Antiviral Research |
| Li PC, Jang J, Hsia CY, et al. (2019) Small molecules targeting the flavivirus E protein with broad-spectrum activity and antiviral efficacy in vivo. Acs Infectious Diseases |
| de Wispelaere M, Lian W, Potisopon S, et al. (2018) Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein. Cell Chemical Biology |