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George Z. Cheng, Ph.D.

Affiliations: 
2007 Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Area:
Molecular Biology, Oncology
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"George Cheng"
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Lu-Hai Wang grad student 2007 Mount Sinai School of Medicine
 (Twist in cancer progression and metastatic program.)

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Publications

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Lang UE, Kocabayoglu P, Cheng GZ, et al. (2013) GSK3β phosphorylation of the KLF6 tumor suppressor promotes its transactivation of p21. Oncogene. 32: 4557-64
Zhang W, Cheng GZ, Gong J, et al. (2008) RACK1 and CIS mediate the degradation of BimEL in cancer cells. The Journal of Biological Chemistry. 283: 16416-26
Cheng GZ, Zhang WZ, Sun M, et al. (2008) Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function. The Journal of Biological Chemistry. 283: 14665-73
Cheng GZ, Park S, Shu S, et al. (2008) Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery. Current Cancer Drug Targets. 8: 2-6
Cheng GZ, Zhang W, Wang LH. (2008) Regulation of cancer cell survival, migration, and invasion by Twist: AKT2 comes to interplay. Cancer Research. 68: 957-60
Cheng GZ, Chan J, Wang Q, et al. (2007) Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel. Cancer Research. 67: 1979-87
Yang L, Sun M, Sun XM, et al. (2007) Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212. The Journal of Biological Chemistry. 282: 10981-7
Kim D, Cheng GZ, Lindsley CW, et al. (2005) Targeting the phosphatidylinositol-3 kinase/Akt pathway for the treatment of cancer. Current Opinion in Investigational Drugs (London, England : 2000). 6: 1250-8
Cheng JQ, Lindsley CW, Cheng GZ, et al. (2005) The Akt/PKB pathway: molecular target for cancer drug discovery. Oncogene. 24: 7482-92
Benzeno S, Narla G, Allina J, et al. (2004) Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1. Cancer Research. 64: 3885-91
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