Chris A. Brosey, Ph.D.

Affiliations: 
2011 Biochemistry Vanderbilt University, Nashville, TN 
Area:
Biochemistry, General Biophysics, Molecular Biology
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"Chris Brosey"

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Walter J. Chazin grad student 2011 Vanderbilt
 (Investigating the architectural basis of RPA quaternary remodeling upon binding ssDNA.)
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Publications

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Brosey CA, Ahmed Z, Lees-Miller SP, et al. (2017) What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses. Methods in Enzymology. 592: 417-455
Brosey CA, Ho C, Long WZ, et al. (2016) Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor. Structure (London, England : 1993)
Brosey CA, Soss SE, Brooks S, et al. (2015) Functional dynamics in replication protein a DNA binding and protein recruitment domains. Structure (London, England : 1993). 23: 1028-38
Kim IK, Stegeman RA, Brosey CA, et al. (2015) A quantitative assay reveals ligand specificity of the DNA scaffold repair protein XRCC1 and efficient disassembly of complexes of XRCC1 and the poly(ADP-ribose) polymerase 1 by poly(ADP-ribose) glycohydrolase. The Journal of Biological Chemistry. 290: 3775-83
Kim IK, Stegeman RA, Brosey CA, et al. (2015) A quantitative assay reveals ligand specificity of the DNA scaffold repair protein XRCC1 and efficient disassembly of complexes of XRCC1 and the poly(ADP-ribose) polymerase 1 by poly(ADP-ribose) glycohydrolase Journal of Biological Chemistry. 290: 3775-3783
Brosey CA, Yan C, Tsutakawa SE, et al. (2013) A new structural framework for integrating replication protein A into DNA processing machinery. Nucleic Acids Research. 41: 2313-27
Brosey CA, Tsutakawa SE, Chazin WJ. (2012) Sample preparation methods to analyze DNA-induced structural changes in replication protein A. Methods in Molecular Biology (Clifton, N.J.). 922: 101-22
Brosey CA, Chagot ME, Chazin WJ. (2012) Preparation of the modular multi-domain protein RPA for study by NMR spectroscopy. Methods in Molecular Biology (Clifton, N.J.). 831: 181-95
Pretto DI, Tsutakawa S, Brosey CA, et al. (2010) Structural dynamics and single-stranded DNA binding activity of the three N-terminal domains of the large subunit of replication protein A from small angle X-ray scattering. Biochemistry. 49: 2880-9
Shell SM, Li Z, Shkriabai N, et al. (2009) Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A. The Journal of Biological Chemistry. 284: 24213-22
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