Brian K. Coombes, Ph.D.
Affiliations: | 2002 | McMaster University, Hamilton, ON, Canada |
Area:
Microbiology Biology, PathologyGoogle:
"Brian Coombes"Parents
Sign in to add mentor| James Mahony | grad student | 2002 | McMaster University | |
| (Cellular and molecular host -pathogen interactions during Chlamydia pneumoniae infection.) | ||||
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Publications
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| Tsai CN, Massicotte MA, MacNair CR, et al. (2023) Screening under infection-relevant conditions reveals chemical sensitivity in multidrug resistant invasive non-typhoidal (iNTS). Rsc Chemical Biology. 4: 600-612 |
| Popov G, Fiebig-Comyn A, Syriste L, et al. (2022) Distinct Molecular Features of NleG Type 3 Secreted Effectors Allow for Different Roles during Citrobacter rodentium Infection in Mice. Infection and Immunity. e0050522 |
| Elhenawy W, Hordienko S, Gould S, et al. (2021) High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn's disease-associated Escherichia coli. Nature Communications. 12: 2032 |
| Chau NYE, Pérez-Morales D, Elhenawy W, et al. (2020) (p)ppGpp-dependent regulation of the nucleotide hydrolase PpnN confers complement resistance in serovar Typhimurium. Infection and Immunity |
| Weber BS, De Jong AM, Guo ABY, et al. (2020) Genetic and Chemical Screening in Human Blood Serum Reveals Unique Antibacterial Targets and Compounds against Klebsiella pneumoniae. Cell Reports. 32: 107927 |
| Tsai CN, MacNair CR, Cao MPT, et al. (2020) Targeting Two-Component Systems Uncovers a Small-Molecule Inhibitor of Salmonella Virulence. Cell Chemical Biology |
| Culp EJ, Waglechner N, Wang W, et al. (2020) Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling. Nature |
| Carfrae LA, MacNair CR, Brown CM, et al. (2019) Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens. Nature Microbiology |
| Shaler CR, Elhenawy W, Coombes BK. (2019) The Unique Lifestyle of Crohn's Disease-Associated Adherent Invasive Escherichia coli. Journal of Molecular Biology |
| Caminero A, McCarville JL, Galipeau HJ, et al. (2019) Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2. Nature Communications. 10: 1198 |