Kenneth C. Keiler
Affiliations: | Pennsylvania State University, State College, PA, United States |
Area:
Microbiology Biology, GeneticsGoogle:
"Kenneth Keiler"
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Publications
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Marathe N, Nguyen HA, Alumasa JN, et al. (2023) Antibiotic that inhibits -translation blocks binding of EF-Tu to tmRNA but not to tRNA. Mbio. e0146123 |
Srinivas P, Keiler KC, Dunham CM. (2022) Druggable differences: Targeting mechanistic differences between trans-translation and translation for selective antibiotic action. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e2200046 |
Aron ZD, Mehrani A, Hoffer ED, et al. (2021) trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo. Nature Communications. 12: 1799 |
Huang Y, Alumasa JN, Callaghan LT, et al. (2019) A Small-Molecule Inhibitor of -Translation Synergistically Interacts with Cathelicidin Antimicrobial Peptides To Impair Survival of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 63 |
Mehrani A, Hoffer ED, Goralski TD, et al. (2019) Investigating the Structural Mechanism of the Stalled Bacterial Ribosome Bound to a Drug that Targets Trans-Translation Biophysical Journal. 116: 573a-574a |
Goralski TDP, Kirimanjeswara GS, Keiler KC. (2018) A New Mechanism for Ribosome Rescue Can Recruit RF1 or RF2 to Nonstop Ribosomes. Mbio. 9 |
Simonson AW, Lawanprasert A, Goralski TDP, et al. (2018) Bioresponsive peptide-polysaccharide nanogels - A versatile delivery system to augment the utility of bioactive cargo. Nanomedicine : Nanotechnology, Biology, and Medicine |
Alumasa JN, Manzanillo PS, Peterson ND, et al. (2017) Ribosome Rescue Inhibitors Kill Actively Growing and Non-replicating Persister Mycobacterium tuberculosis Cells. Acs Infectious Diseases |
Alumasa JN, Goralski TDP, Keiler KC. (2017) Tetrazole-Based trans-Translation Inhibitors Kill Bacillus anthracis Spores to Protect Host Cells. Antimicrobial Agents and Chemotherapy |
Dillon NA, Peterson ND, Feaga HA, et al. (2017) Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA. Scientific Reports. 7: 6135 |