Kenneth C. Keiler

Affiliations: 
Pennsylvania State University, State College, PA, United States 
Area:
Microbiology Biology, Genetics
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"Kenneth Keiler"
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Publications

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Marathe N, Nguyen HA, Alumasa JN, et al. (2023) Antibiotic that inhibits -translation blocks binding of EF-Tu to tmRNA but not to tRNA. Mbio. e0146123
Srinivas P, Keiler KC, Dunham CM. (2022) Druggable differences: Targeting mechanistic differences between trans-translation and translation for selective antibiotic action. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e2200046
Aron ZD, Mehrani A, Hoffer ED, et al. (2021) trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo. Nature Communications. 12: 1799
Huang Y, Alumasa JN, Callaghan LT, et al. (2019) A Small-Molecule Inhibitor of -Translation Synergistically Interacts with Cathelicidin Antimicrobial Peptides To Impair Survival of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 63
Mehrani A, Hoffer ED, Goralski TD, et al. (2019) Investigating the Structural Mechanism of the Stalled Bacterial Ribosome Bound to a Drug that Targets Trans-Translation Biophysical Journal. 116: 573a-574a
Goralski TDP, Kirimanjeswara GS, Keiler KC. (2018) A New Mechanism for Ribosome Rescue Can Recruit RF1 or RF2 to Nonstop Ribosomes. Mbio. 9
Simonson AW, Lawanprasert A, Goralski TDP, et al. (2018) Bioresponsive peptide-polysaccharide nanogels - A versatile delivery system to augment the utility of bioactive cargo. Nanomedicine : Nanotechnology, Biology, and Medicine
Alumasa JN, Manzanillo PS, Peterson ND, et al. (2017) Ribosome Rescue Inhibitors Kill Actively Growing and Non-replicating Persister Mycobacterium tuberculosis Cells. Acs Infectious Diseases
Alumasa JN, Goralski TDP, Keiler KC. (2017) Tetrazole-Based trans-Translation Inhibitors Kill Bacillus anthracis Spores to Protect Host Cells. Antimicrobial Agents and Chemotherapy
Dillon NA, Peterson ND, Feaga HA, et al. (2017) Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA. Scientific Reports. 7: 6135
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