☰

Irving Hyman Goldberg, Ph.D., M.D.

Affiliations: 
Biological Chemistry & Molecular Pharmacology Harvard Medical School, Boston, MA, United States 
Website:
http://bcmp.hms.harvard.edu/person/emeritus/irving-goldberg
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"Irving Goldberg"
Bio:

John Simon Guggenheim Memorial Foundation Fellowship, 1970
https://www.gf.org/fellows/all-fellows/irving-goldberg/
Gustavus Adolphus Pfeiffer Professor of Pharmacology, 1972-1983
Otto Krayer Professorship of Pharmacology, 1983 -

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Lawrence F. Povirk research scientist 1982-1985 Harvard Medical School

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Ma D, Lin Y, Xiao Z, et al. (2009) Designed DNA probes from the neocarzinostatin family: impact of glycosyl linkage stereochemistry on bulge base binding. Bioorganic & Medicinal Chemistry. 17: 2428-32
Jones GB, Lin Y, Ma D, et al. (2008) Congeners of the enediyne neocarzinostatin chromophore: designed agents for bulged nucleic acid targets. Current Topics in Medicinal Chemistry. 8: 436-47
Zhang N, Lin Y, Xiao Z, et al. (2007) Solution structure of a designed spirocyclic helical ligand binding at a two-base bulge site in DNA. Biochemistry. 46: 4793-803
Kappen LS, Lin Y, Jones GB, et al. (2007) Probing DNA bulges with designed helical spirocyclic molecules. Biochemistry. 46: 561-7
Jones GB, Lin Y, Xiao Z, et al. (2007) Molecular probes of DNA bulges: functional assay and spectroscopic analysis. Bioorganic & Medicinal Chemistry. 15: 784-90
Xiao Z, Kappen LS, Goldberg IH. (2006) Development of new simple molecular probes of DNA bulged structures. Bioorganic & Medicinal Chemistry Letters. 16: 2895-9
Lin Y, Jones GB, Hwang GS, et al. (2005) Convenient synthesis of NCS-chromophore metabolite isosteres: binding agents for bulged DNA microenvironments. Organic Letters. 7: 71-4
Gaikwad NW, Hwang GS, Goldberg IH. (2004) Synthesis and NMR binding study of a chiral spirocyclic helical analogue of a natural DNA bulge binder. Organic Letters. 6: 4833-6
Fouad FS, Xi Z, Goldberg IH, et al. (2004) Preparation of alkylation agents for bulged DNA microenvironments. Bioorganic & Medicinal Chemistry Letters. 14: 3337-9
Hwang GS, Jones GB, Goldberg IH. (2004) Stereochemical control of small molecule binding to bulged DNA: comparison of structures of spirocyclic enantiomer-bulged DNA complexes. Biochemistry. 43: 641-50
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