David J McGee, Ph.D.

Affiliations: 
1988-1992 Biology Philadelphia College of Pharmacy and Science 
 1992-1997 Microbiology and Immunology Drexel University College of Medicine, Philadelphia, PA, United States 
 2001-2005 Microbiology and Immunology University of South Alabama, Mobile, AL, United States 
 2005- Microbiology and Immunology LSU Health Sciences Center-Shreveport 
Area:
Helicobacter pylori, Arcanobacterium haemolyticum, host-pathogen interactions, urease, arginase, toxins
Google:
"David McGee"
Bio:

BS in Microbiology from Philadelphia College of Pharmacy and Science (now University of Sciences in Philadelphia), trained with Kenneth W. Thomulka.
Ph. D. in Microbiology and Immunology from Allegheny University of the Health Sciences (was Hahnemann University, now Drexel University), trained with Richard F. Rest.
Postdoc in Microbiology and Immunology at University of Maryland Baltimore, trained with Harry L. T. Mobley.

Host-pathogen interactions of Nesseria gonorrhoeae (1992-97), Helicobacter pylori (1997-present), and Arcanobacterium haemolyticum (2004-present). Also studied water toxicity using bioluminescene as indicator (1989-1992). Has worked on urease, arginase, motility, LPS and other areas. Has trained over 100 people not listed here (including many undergraduate students, research technicians, medical students, and high school students). Listed are the graduate students and postdocs trained.

Parents

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Kenneth W. Thomulka research assistant 1989-1992 Philadelphia College of Pharmacy and Science
 (Bioluminescence as a water toxicity indicator)
Richard F. Rest grad student 1992-1997 Drexel Medical School
 (Neisseria gonorrhoeae)
Harry L. T. Mobley post-doc 1997-2001 University of Maryland, Baltimore (Chemistry Tree)
 (Helicobacter pylori, urease, arginase)
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Publications

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Gellings PS, McGee DJ. (2019) utilizes both Phospholipase D and Arcanolysin to mediate its uptake into non-phagocytic cells. Infection and Immunity
McGee DJ, Lu XH, Disbrow EA. (2018) Stomaching the Possibility of a Pathogenic Role for Helicobacter pylori in Parkinson's Disease. Journal of Parkinson's Disease
Gellings PS, McGee DJ. (2018) Phospholipase D Enzymatic Activity Promotes the Hemolytic Activity of the Cholesterol-Dependent Cytolysin Arcanolysin. Toxins. 10
Ruther HS, Phillips K, Ross D, et al. (2015) Smooth and Rough Biotypes of Arcanobacterium haemolyticum Can Be Genetically Distinguished at the Arcanolysin Locus. Plos One. 10: e0137346
Shimomura H, Hosoda K, Mcgee DJ, et al. (2013) Detoxification of 7-dehydrocholesterol fatal to Helicobacter pylori is a novel role of cholesterol glucosylation Journal of Bacteriology. 195: 359-367
Monceaux CP, Testerman TL, Boktor M, et al. (2013) <i>Helicobacter</i> infection decreases basal colon inflammation, but increases disease activity in experimental IBD Open Journal of Gastroenterology. 3: 177-189
Kim SH, Sierra RA, McGee DJ, et al. (2012) Transcriptional profiling of gastric epithelial cells infected with wild type or arginase-deficient Helicobacter pylori. Bmc Microbiology. 12: 175
Jost BH, Lucas EA, Billington SJ, et al. (2011) Arcanolysin is a cholesterol-dependent cytolysin of the human pathogen Arcanobacterium haemolyticum. Bmc Microbiology. 11: 239
Kim SH, Langford ML, Boucher JL, et al. (2011) Helicobacter pylori arginase mutant colonizes arginase II knockout mice. World Journal of Gastroenterology. 17: 3300-9
Senkovich OA, Yin J, Ekshyyan V, et al. (2011) Helicobacter pylori AlpA and AlpB bind host laminin and influence gastric inflammation in gerbils. Infection and Immunity. 79: 3106-16
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