Keith P. Romano
Affiliations: | 2017- | Harvard University, Cambridge, MA, United States |
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"Keith Romano"
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| Warrier T, Romano KP, Clatworthy AE, et al. (2022) Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation. Cell Chemical Biology. 29: 716-729 |
| Romano KP, Warrier T, Poulsen BE, et al. (2019) Mutations in confer cross-resistance between the LptD inhibitor POL7080 and colistin in . Antimicrobial Agents and Chemotherapy |
| Clatworthy AE, Romano KP, Hung DT. (2018) Whole-organism phenotypic screening for anti-infectives promoting host health. Nature Chemical Biology |
| Ali A, Aydin C, Gildemeister R, et al. (2013) Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance. Acs Chemical Biology. 8: 1469-78 |
| Romano KP, Ali A, Aydin C, et al. (2012) The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors. Plos Pathogens. 8: e1002832 |
| Romano KP, Laine JM, Deveau LM, et al. (2011) Molecular mechanisms of viral and host cell substrate recognition by hepatitis C virus NS3/4A protease. Journal of Virology. 85: 6106-16 |
| Romano KP, Ali A, Royer WE, et al. (2010) Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding. Proceedings of the National Academy of Sciences of the United States of America. 107: 20986-91 |
| Romano K. (2009) Analyzing drug-resistance in terms of substrate recognition by Hepatitis C Virus NS3 protease Biophysical Journal. 96 |
| Prabu-Jeyabalan M, Nalivaika EA, Romano K, et al. (2006) Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate. Journal of Virology. 80: 3607-16 |