| Year |
Citation |
Score |
| 2022 |
Vengeliene V, Spanagel R. mGlu2 mechanism-based interventions to treat alcohol relapse. Frontiers in Pharmacology. 13: 985954. PMID 36188569 DOI: 10.3389/fphar.2022.985954 |
0.323 |
|
| 2022 |
Foo JC, Meinhardt MW, Skorodumov I, Spanagel R. Alcohol solution strength preference predicts compulsive-like drinking behavior in rats. Alcoholism, Clinical and Experimental Research. PMID 35871774 DOI: 10.1111/acer.14910 |
0.301 |
|
| 2021 |
Meinhardt MW, Giannone F, Hirth N, Bartsch D, Spampinato SM, Kelsch W, Spanagel R, Sommer WH, Hansson AC. Disrupted circadian expression of β-arrestin 2 affects reward-related µ-opioid receptor function in alcohol dependence. Journal of Neurochemistry. PMID 34919270 DOI: 10.1111/jnc.15559 |
0.318 |
|
| 2021 |
Wei S, Hertle S, Spanagel R, Bilbao A. NMDA Receptors in Accumbal D1 Neurons Influence Chronic Sugar Consumption and Relapse. Eneuro. 8. PMID 33906970 DOI: 10.1523/ENEURO.0029-21.2021 |
0.32 |
|
| 2020 |
Hansson AC, Spanagel R. No changes in the oxytocin system in alcohol-dependent female rodents and humans: Towards a sex-specific psychopharmacology in alcoholism. Addiction Biology. e12945. PMID 32761675 DOI: 10.1111/Adb.12945 |
0.382 |
|
| 2020 |
Meinhardt MW, Güngör C, Skorodumov I, Mertens LJ, Spanagel R. Psilocybin and LSD have no long-lasting effects in an animal model of alcohol relapse. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32369828 DOI: 10.1038/S41386-020-0694-Z |
0.379 |
|
| 2020 |
Bilbao A, Neuhofer D, Sepers M, Wei SP, Eisenhardt M, Hertle S, Lassalle O, Ramos-Uriarte A, Puente N, Lerner R, Grandes P, Lutz B, Manzoni OJ, Spanagel R. Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior. Iscience. 23: 100951. PMID 32179475 DOI: 10.1016/J.Isci.2020.100951 |
0.405 |
|
| 2020 |
Witt SH, Frank J, Frischknecht U, Treutlein J, Streit F, Foo JC, Sirignano L, Dukal H, Degenhardt F, Koopmann A, Hoffmann S, Koller G, Pogarell O, Preuss UW, Zill P, ... ... Spanagel R, et al. Acute alcohol withdrawal and recovery in men lead to profound changes in DNA methylation profiles - a longitudinal clinical study. Addiction (Abingdon, England). PMID 32080920 DOI: 10.1111/Add.15020 |
0.376 |
|
| 2019 |
Heinz A, Kiefer F, Smolka MN, Endrass T, Beste C, Beck A, Liu S, Genauck A, Romund L, Banaschewski T, Bermpohl F, Deserno L, Dolan RJ, Durstewitz D, Ebner-Priemer U, ... ... Spanagel R, et al. Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)-From trajectories to mechanisms and interventions. Addiction Biology. e12866. PMID 31859437 DOI: 10.1111/Adb.12866 |
0.328 |
|
| 2019 |
Egenrieder L, Mitricheva E, Spanagel R, Noori HR. No basal or drug-induced sex differences in striatal dopaminergic levels: a cluster and meta-analysis of rat microdialysis studies. Journal of Neurochemistry. PMID 31705667 DOI: 10.1111/Jnc.14911 |
0.333 |
|
| 2019 |
Takahashi TT, Vengeliene V, Enkel T, Reithofer S, Spanagel R. Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in Rats. Frontiers in Behavioral Neuroscience. 13: 129. PMID 31275122 DOI: 10.3389/Fnbeh.2019.00129 |
0.411 |
|
| 2019 |
Bilbao A, Leixner S, Wei S, Cantacorps L, Valverde O, Spanagel R. Reduced sensitivity to ethanol and excessive drinking in a mouse model of neuropathic pain. Addiction Biology. e12784. PMID 31237390 DOI: 10.1111/Adb.12784 |
0.365 |
|
| 2019 |
Bernardi RE, Olevska A, Morella I, Fasano S, Santos E, Brambilla R, Spanagel R. The inhibition of RasGRF2, but not RasGRF1, alters cocaine reward in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31182637 DOI: 10.1523/Jneurosci.1120-18.2019 |
0.378 |
|
| 2019 |
Foo JC, Vengeliene V, Noori HR, Yamaguchi I, Morita K, Nakamura T, Yamamoto Y, Spanagel R. Drinking Levels and Profiles of Alcohol Addicted Rats Predict Response to Nalmefene. Frontiers in Pharmacology. 10: 471. PMID 31133855 DOI: 10.3389/Fphar.2019.00471 |
0.426 |
|
| 2019 |
Witt S, Frank J, Treutlein J, Streit F, Frischknecht U, Foo J, Degenhardt F, Adorjan K, Nöthen M, Spanagel R, Kiefer F, Rietschel M. Sa63Methylation Profiles During Acute Alcohol Withdrawal In A Clinical Sample European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2018.08.285 |
0.358 |
|
| 2018 |
Hansson AC, Gründer G, Hirth N, Noori HR, Spanagel R, Sommer WH. Dopamine and opioid systems adaptation in alcoholism revisited: Convergent evidence from positron emission tomography and postmortem studies. Neuroscience and Biobehavioral Reviews. PMID 30243576 DOI: 10.1016/J.Neubiorev.2018.09.010 |
0.396 |
|
| 2018 |
van den Brink W, Addolorato G, Aubin HJ, Benyamina A, Caputo F, Dematteis M, Gual A, Lesch OM, Mann K, Maremmani I, Nutt D, Paille F, Perney P, Rehm J, Reynaud M, ... ... Spanagel R, et al. Efficacy and safety of sodium oxybate in alcohol-dependent patients with a very high drinking risk level. Addiction Biology. 23: 969-986. PMID 30043457 DOI: 10.1111/Adb.12645 |
0.393 |
|
| 2018 |
Cannella N, Oliveira AMM, Hemstedt T, Lissek T, Buechler E, Bading H, Spanagel R. Dnmt3a2 in the Nucleus Accumbens Shell Is Required for Reinstatement of Cocaine Seeking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 38: 7516-7528. PMID 30030395 DOI: 10.1523/Jneurosci.0600-18.2018 |
0.403 |
|
| 2018 |
Streit F, Treutlein J, Frischknecht U, Hermann D, Mann K, Kiefer F, Sack M, Hall ASM, Frank J, Witt SH, Foo JC, Degenhardt F, Heilmann-Heimbach S, Nöthen MM, Sommer WH, ... Spanagel R, et al. Glutamate concentration in the anterior cingulate cortex in alcohol dependence: association with alcohol withdrawal and exploration of contribution from glutamatergic candidate genes. Psychiatric Genetics. PMID 29985185 DOI: 10.1097/Ypg.0000000000000202 |
0.395 |
|
| 2018 |
Spanagel R. Aberrant choice behavior in alcoholism. Science (New York, N.Y.). 360: 1298-1299. PMID 29930124 DOI: 10.1126/Science.Aau0668 |
0.393 |
|
| 2018 |
Baron J, Bilbao A, Hörtnagl H, Birnbaumer L, Leixner S, Spanagel R, Ahnert-Hilger G, Brunk I. Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system. Journal of Neurochemistry. PMID 29747224 DOI: 10.1111/Jnc.14460 |
0.336 |
|
| 2018 |
Broccoli L, Uhrig S, von Jonquieres G, Schönig K, Bartsch D, Justice NJ, Spanagel R, Sommer WH, Klugmann M, Hansson AC. Targeted overexpression of CRH receptor subtype 1 in central amygdala neurons: effect on alcohol-seeking behavior. Psychopharmacology. 235: 1821-1833. PMID 29700576 DOI: 10.1007/S00213-018-4908-6 |
0.407 |
|
| 2018 |
Vengeliene V, Takahashi TT, Dravolina OA, Belozertseva I, Zvartau E, Bespalov AY, Spanagel R. Efficacy and side effects of baclofen and the novel GABA receptor positive allosteric modulator CMPPE in animal models for alcohol and cocaine addiction. Psychopharmacology. PMID 29651507 DOI: 10.1007/S00213-018-4893-9 |
0.34 |
|
| 2018 |
Pfarr S, Schaaf L, Reinert JK, Paul E, Herrmannsdörfer F, Roßmanith M, Kuner T, Hansson AC, Spanagel R, Körber C, Sommer WH. Choice for drug or natural reward engages largely overlapping neuronal ensembles in the infralimbic prefrontal cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29483279 DOI: 10.1523/Jneurosci.0026-18.2018 |
0.373 |
|
| 2018 |
Bazov I, Sarkisyan D, Kononenko O, Watanabe H, Yakovleva T, Hansson AC, Sommer WH, Spanagel R, Bakalkin G. Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics. Molecular Neurobiology. PMID 29383684 DOI: 10.1007/S12035-017-0844-4 |
0.428 |
|
| 2018 |
Vengeliene V, Rossmanith M, Takahashi TT, Alberati D, Behl B, Bespalov A, Spanagel R. Targeting Glycine Reuptake in Alcohol Seeking and Relapse. The Journal of Pharmacology and Experimental Therapeutics. PMID 29367277 DOI: 10.1124/Jpet.117.244822 |
0.444 |
|
| 2018 |
Treutlein J, Spanagel R. Genetische Aspekte bei Alkoholismus Biospektrum. 24: 260-263. DOI: 10.1007/S12268-018-0916-7 |
0.356 |
|
| 2017 |
Bernardi RE, Broccoli L, Hirth N, Justice NJ, Deussing JM, Hansson AC, Spanagel R. Dissociable Role of Corticotropin Releasing Hormone Receptor Subtype 1 on Dopaminergic and D1 Dopaminoceptive Neurons in Cocaine Seeking Behavior. Frontiers in Behavioral Neuroscience. 11: 221. PMID 29180955 DOI: 10.3389/Fnbeh.2017.00221 |
0.414 |
|
| 2017 |
Cannella N, Cosa-Linan A, Roscher M, Takahashi TT, Vogler N, Wängler B, Spanagel R. [18F]-Fluorodeoxyglucose-Positron Emission Tomography in Rats with Prolonged Cocaine Self-Administration Suggests Potential Brain Biomarkers for Addictive Behavior. Frontiers in Psychiatry. 8: 218. PMID 29163237 DOI: 10.3389/Fpsyt.2017.00218 |
0.38 |
|
| 2017 |
Hansson AC, Koopmann A, Uhrig S, Bühler S, Domi E, Kiessling E, Ciccocioppo R, Froemke RC, Grinevich V, Kiefer F, Sommer WH, Vollstädt-Klein S, Spanagel R. Oxytocin Reduces Alcohol Cue-Reactivity in Alcohol Dependent Rats and Humans. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29090683 DOI: 10.1038/Npp.2017.257 |
0.444 |
|
| 2017 |
Foo JC, Noori HR, Yamaguchi I, Vengeliene V, Cosa-Linan A, Nakamura T, Morita K, Spanagel R, Yamamoto Y. Dynamical state transitions into addictive behaviour and their early-warning signals. Proceedings. Biological Sciences. 284. PMID 28768888 DOI: 10.1098/Rspb.2017.0882 |
0.367 |
|
| 2017 |
Treutlein J, Frank J, Streit F, Reinbold CS, Juraeva D, Degenhardt F, Rietschel L, Witt SH, Forstner AJ, Ridinger M, Strohmaier J, Wodarz N, Dukal H, Foo JC, Hoffmann P, ... ... Spanagel R, et al. Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. Genes. 8. PMID 28714907 DOI: 10.3390/Genes8070183 |
0.363 |
|
| 2017 |
Gispert JD, Figueiras FP, Vengeliene V, Herance JR, Rojas S, Spanagel R. Changes in cerebral [(18)F]-FDG uptake induced by acute alcohol administration in a rat model of alcoholism. Behavioural Brain Research. PMID 28347826 DOI: 10.1016/J.Bbr.2017.03.038 |
0.385 |
|
| 2017 |
Takahashi TT, Vengeliene V, Spanagel R. Melatonin reduces motivation for cocaine self-administration and prevents relapse-like behavior in rats. Psychopharmacology. PMID 28246896 DOI: 10.1007/S00213-017-4576-Y |
0.365 |
|
| 2017 |
Perreau-Lenz S, Hoelters LS, Leixner S, Sanchis-Segura C, Hansson A, Bilbao A, Spanagel R. mPer1 promotes morphine-induced locomotor sensitization and conditioned place preference via histone deacetylase activity. Psychopharmacology. PMID 28243713 DOI: 10.1007/S00213-017-4574-0 |
0.34 |
|
| 2017 |
Cannella N, Cosa-Linan A, Büchler E, Falfan-Melgoza C, Weber-Fahr W, Spanagel R. In vivo structural imaging in rats reveals neuroanatomical correlates of behavioral sub-dimensions of cocaine addiction. Addiction Biology. PMID 28231635 DOI: 10.1111/Adb.12500 |
0.394 |
|
| 2017 |
Vengeliene V, Bespalov A, Roßmanith M, Horschitz S, Berger S, Relo AL, Noori HR, Schneider P, Enkel T, Bartsch D, Schneider M, Behl B, Hansson AC, Schloss P, Spanagel R. Towards trans-diagnostic mechanisms in psychiatry: Neurobehavioral profile of rats with a loss of function point mutation in the dopamine transporter gene. Disease Models & Mechanisms. PMID 28167616 DOI: 10.1242/Dmm.027623 |
0.341 |
|
| 2017 |
Frischknecht U, Hermann D, Tunc-Skarka N, Wang GY, Sack M, van Eijk J, Demirakca T, Falfan-Melgoza C, Krumm B, Dieter S, Spanagel R, Kiefer F, Mann KF, Sommer WH, Ende G, et al. Negative Association Between MR-Spectroscopic Glutamate Markers and Gray Matter Volume After Alcohol Withdrawal in the Hippocampus: A Translational Study in Humans and Rats. Alcoholism, Clinical and Experimental Research. PMID 28098946 DOI: 10.1111/Acer.13308 |
0.415 |
|
| 2017 |
Spanagel R. S11-4Oxytocin System And Alcohol Reward: From Rodents To Man Alcohol and Alcoholism. 52. DOI: 10.1093/Alcalc/Agx075.41 |
0.389 |
|
| 2017 |
Spanagel R, Cannella N, Vengeliene V, Cosa-Linan A, Takahashi T. Translational FDG-PET studies in alcohol and cocaine addicted rats Alcohol. 60: 215-216. DOI: 10.1016/J.Alcohol.2017.02.238 |
0.413 |
|
| 2016 |
Uhrig S, Vandael D, Marcantoni A, Dedic N, Bilbao A, Vogt MA, Hirth N, Broccoli L, Bernardi RE, Schönig K, Gass P, Bartsch D, Spanagel R, Deussing JM, Sommer WH, et al. Differential Roles for L-Type Calcium Channel Subtypes in Alcohol Dependence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27905406 DOI: 10.1038/Npp.2016.266 |
0.425 |
|
| 2016 |
Schuster R, Koopmann A, Grosshans M, Reinhard I, Spanagel R, Kiefer F. Association of plasma calcium concentrations with alcohol craving: New data on potential pathways. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 27890540 DOI: 10.1016/J.Euroneuro.2016.11.007 |
0.351 |
|
| 2016 |
Domi E, Uhrig S, Soverchia L, Spanagel R, Hansson AC, Barbier E, Heilig M, Ciccocioppo R, Ubaldi M. Genetic deletion of neuronal PPARγ enhances the emotional response to acute stress and exacerbates anxiety: An effect reversed by rescue of amygdala PPARγ function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 27810934 DOI: 10.1523/Jneurosci.4127-15.2016 |
0.305 |
|
| 2016 |
Luís C, Cannella N, Spanagel R, Köhr G. Persistent strengthening of the prefrontal cortex - nucleus accumbens pathway during incubation of cocaine-seeking behavior. Neurobiology of Learning and Memory. PMID 27720809 DOI: 10.1016/J.Nlm.2016.10.003 |
0.413 |
|
| 2016 |
Hadar R, Voget M, Vengeliene V, Haumesser JK, van Riesen C, Avchalumov Y, Spanagel R, Winter C. Altered neural oscillations and elevated dopamine levels in the reward pathway during alcohol relapse. Behavioural Brain Research. 316: 131-135. PMID 27569184 DOI: 10.1016/J.Bbr.2016.08.045 |
0.421 |
|
| 2016 |
Papale A, Morella IM, Indrigo MT, Eugene Bernardi R, Marrone L, Marchisella F, Brancale A, Spanagel R, Brambilla R, Fasano S. Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors. Elife. 5. PMID 27557444 DOI: 10.7554/Elife.17111 |
0.362 |
|
| 2016 |
Hermann D, Hirth N, Reimold M, Batra A, Smolka MN, Hoffmann S, Kiefer F, Noori HR, Sommer WH, Reischl G, la Fougère C, Mann K, Spanagel R, Hansson AC. Low μ-Opioid Receptor Status in Alcohol Dependence Identified by Combined Positron Emission Tomography and Post-Mortem Brain Analysis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27510425 DOI: 10.1038/Npp.2016.145 |
0.389 |
|
| 2016 |
Vengeliene V, Cannella N, Takahashi T, Spanagel R. Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse. Psychopharmacology. PMID 27475106 DOI: 10.1007/S00213-016-4384-9 |
0.385 |
|
| 2016 |
Noori HR, Cosa Linan A, Spanagel R. Largely overlapping neuronal substrates of reactivity to drug, gambling, food and sexual cues: A comprehensive meta-analysis. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 27397863 DOI: 10.1016/J.Euroneuro.2016.06.013 |
0.351 |
|
| 2016 |
Degenhardt F, Krämer L, Frank J, Treutlein J, Heilmann-Heimbach S, Hecker J, Fier HL, Lang M, Witt SH, Koller AC, Mann K, Hoffmann S, Kiefer F, Spanagel R, Rietschel M, et al. Analysis of Rare Variants in the Alcohol Dependence Candidate Gene GATA4. Alcoholism, Clinical and Experimental Research. PMID 27374936 DOI: 10.1111/Acer.13125 |
0.328 |
|
| 2016 |
Hadar R, Vengeliene V, Hlusicke EB, Canals S, Noori HR, Wieske F, Rummel J, Harnack D, Heinz A, Spanagel R, Winter C. Paradoxical augmented relapse in alcohol-dependent rats during deep-brain stimulation in the nucleus accumbens Translational Psychiatry. 6: 1-9. PMID 27327255 DOI: 10.1038/Tp.2016.100 |
0.381 |
|
| 2016 |
Heilig M, Sommer WH, Spanagel R. The Need for Treatment Responsive Translational Biomarkers in Alcoholism Research. Current Topics in Behavioral Neurosciences. PMID 27240677 DOI: 10.1007/7854_2015_5006 |
0.408 |
|
| 2016 |
Hirth N, Meinhardt MW, Noori HR, Salgado H, Torres-Ramirez O, Uhrig S, Broccoli L, Vengeliene V, Roßmanith M, Perreau-Lenz S, Köhr G, Sommer WH, Spanagel R, Hansson AC. Convergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protracted abstinence. Proceedings of the National Academy of Sciences of the United States of America. PMID 26903621 DOI: 10.1073/Pnas.1506012113 |
0.442 |
|
| 2016 |
Spanagel R, Vengeliene V, Kiefer F. Reply to: Does acamprosate really produce its anti-relapse effects via calcium? No support from the PREDICT study in human alcoholics. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 41: 661-2. PMID 26742861 DOI: 10.1038/Npp.2015.263 |
0.327 |
|
| 2016 |
Papale A, Morella IM, Indrigo MT, Bernardi RE, Marrone L, Marchisella F, Brancale A, Spanagel R, Brambilla R, Fasano S. Author response: Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors Elife. DOI: 10.7554/Elife.17111.021 |
0.327 |
|
| 2015 |
Stacey D, Lourdusamy A, Ruggeri B, Maroteaux M, Jia T, Cattrell A, Nymberg C, Banaschewski T, Bhattacharyya S, Band H, Barker G, Bokde A, Buchel C, Carvalho F, Conrod P, ... ... Spanagel R, et al. A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males. Journal of Psychiatry & Neuroscience : Jpn. 41: 150138. PMID 26679926 DOI: 10.1503/Jpn.150138 |
0.394 |
|
| 2015 |
Eisenhardt M, Leixner S, Luján R, Spanagel R, Bilbao A. Glutamate Receptors within the Mesolimbic Dopamine System Mediate Alcohol Relapse Behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 15523-38. PMID 26609150 DOI: 10.1523/Jneurosci.2970-15.2015 |
0.466 |
|
| 2015 |
Eisenhardt M, Leixner S, Spanagel R, Bilbao A. Quantification of alcohol drinking patterns in mice. Addiction Biology. PMID 26515884 DOI: 10.1111/Adb.12325 |
0.41 |
|
| 2015 |
Bernardi RE, Broccoli L, Spanagel R, Hansson AC. Sex differences in dopamine binding and modafinil conditioned place preference in mice. Drug and Alcohol Dependence. 155: 37-44. PMID 26342627 DOI: 10.1016/J.Drugalcdep.2015.08.016 |
0.335 |
|
| 2015 |
Vengeliene V, Olevska A, Spanagel R. Long-lasting effect of NMDA receptor antagonist memantine on ethanol-cue association and relapse. Journal of Neurochemistry. PMID 26342155 DOI: 10.1111/Jnc.13350 |
0.418 |
|
| 2015 |
Pfarr S, Meinhardt MW, Klee ML, Hansson AC, Vengeliene V, Schönig K, Bartsch D, Hope BT, Spanagel R, Sommer WH. Losing Control: Excessive Alcohol Seeking after Selective Inactivation of Cue-Responsive Neurons in the Infralimbic Cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10750-61. PMID 26224858 DOI: 10.1093/Alcalc/Agv080.67 |
0.402 |
|
| 2015 |
Vengeliene V, Moeller A, Meinhardt MW, Beardsley PM, Sommer WH, Spanagel R, Bespalov A. The Calpain Inhibitor A-705253 Attenuates Alcohol-Seeking and Relapse with Low Side-Effect Profile. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26216521 DOI: 10.1038/Npp.2015.225 |
0.446 |
|
| 2015 |
Ojelade SA, Jia T, Rodan AR, Chenyang T, Kadrmas JL, Cattrell A, Ruggeri B, Charoen P, Lemaitre H, Banaschewski T, Büchel C, Bokde AL, Carvalho F, Conrod PJ, Flor H, ... ... Spanagel R, et al. Rsu1 regulates ethanol consumption in Drosophila and humans. Proceedings of the National Academy of Sciences of the United States of America. 112: E4085-93. PMID 26170296 DOI: 10.1073/Pnas.1417222112 |
0.347 |
|
| 2015 |
Vengeliene V, Noori HR, Spanagel R. Activation of Melatonin Receptors Reduces Relapse-Like Alcohol Consumption. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 2897-906. PMID 25994077 DOI: 10.1038/Npp.2015.143 |
0.421 |
|
| 2015 |
Ruggeri B, Nymberg C, Vuoksimaa E, Lourdusamy A, Wong CP, Carvalho FM, Jia T, Cattrell A, Macare C, Banaschewski T, Barker GJ, Bokde AL, Bromberg U, Büchel C, Conrod PJ, ... ... Spanagel R, et al. Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis. The American Journal of Psychiatry. 172: 543-52. PMID 25982659 DOI: 10.1176/Appi.Ajp.2014.14030382 |
0.339 |
|
| 2015 |
Perreau-Lenz S, Spanagel R. Clock genes × stress × reward interactions in alcohol and substance use disorders. Alcohol (Fayetteville, N.Y.). 49: 351-7. PMID 25943583 DOI: 10.1016/J.Alcohol.2015.04.003 |
0.393 |
|
| 2015 |
Bach P, Vollsta Dt-Klein S, Kirsch M, Hoffmann S, Jorde A, Frank J, Charlet K, Beck A, Heinz A, Walter H, Sommer WH, Spanagel R, Rietschel M, Kiefer F. Increased mesolimbic cue-reactivity in carriers of the mu-opioid-receptor gene OPRM1 A118G polymorphism predicts drinking outcome: A functional imaging study in alcohol dependent subjects. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 25937240 DOI: 10.1016/J.Euroneuro.2015.04.013 |
0.422 |
|
| 2015 |
Eisenhardt M, Hansson AC, Spanagel R, Bilbao A. Chronic intermittent ethanol exposure in mice leads to an up-regulation of CRH/CRHR1 signaling. Alcoholism, Clinical and Experimental Research. 39: 752-62. PMID 25833034 DOI: 10.1111/Acer.12686 |
0.392 |
|
| 2015 |
Kiefer F, Kirsch M, Bach P, Hoffmann S, Reinhard I, Jorde A, von der Goltz C, Spanagel R, Mann K, Loeber S, Vollstädt-Klein S. Effects of D-cycloserine on extinction of mesolimbic cue reactivity in alcoholism: a randomized placebo-controlled trial. Psychopharmacology. 232: 2353-62. PMID 25697860 DOI: 10.1007/S00213-015-3882-5 |
0.41 |
|
| 2015 |
Bilbao A, Robinson JE, Heilig M, Malanga CJ, Spanagel R, Sommer WH, Thorsell A. A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice. Biological Psychiatry. 77: 850-8. PMID 25442002 DOI: 10.1016/J.Biopsych.2014.08.021 |
0.387 |
|
| 2015 |
Juraeva D, Treutlein J, Scholz H, Frank J, Degenhardt F, Cichon S, Ridinger M, Mattheisen M, Witt SH, Lang M, Sommer WH, Hoffmann P, Herms S, Wodarz N, Soyka M, ... ... Spanagel R, et al. XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 361-71. PMID 25035082 DOI: 10.1038/Npp.2014.178 |
0.377 |
|
| 2015 |
Spanagel R. Pl3A Systems Medicine Approach Towards Understanding Alcohol Addiction Alcohol and Alcoholism. 50. DOI: 10.1093/Alcalc/Agv077.03 |
0.371 |
|
| 2015 |
Vengeliene V, Moeller A, Meinhardt MW, Beardsley P, Sommer WH, Spanagel R, Bespalov A. Sy09-2The Calpain Inhibitor A-705253 Attenuates Alcohol-Seeking And Relapse With Low Side-Effect Profile Alcohol and Alcoholism. 50. DOI: 10.1093/Alcalc/Agv076.35 |
0.398 |
|
| 2015 |
Spanagel R. Sat1-2The Role Of The Opioid Systems In The Brains Motivational System Alcohol and Alcoholism. 50. DOI: 10.1093/Alcalc/Agv076.123 |
0.402 |
|
| 2015 |
Broccoli L, Jüngling K, Borroto-Escuela DO, Spanagel R, Sommer WH, Pape HC, Fuxe K, Deussing JM, Hansson AC. SY28-4CROSS-TALK OF CORTICOTROPIN RELEASING HORMONE RECEPTOR SUBTYPE 1 WITH DOPAMINE D1 RECEPTOR: FUNCTIONAL RELEVANCE IN ALCOHOL DEPENDENCE Alcohol and Alcoholism. 50: i31.4-i31. DOI: 10.1093/Alcalc/Agv076.116 |
0.414 |
|
| 2015 |
Hirth N, Sommer WH, Bakalkin G, Spanagel R, Hansson AC. SY03-3OPIOIDERGIC MECHANISM IN ALCOHOLISM: TRANSLATIONAL STUDIES IN RODENTS AND HUMANS Alcohol and Alcoholism. 50: i5.1-i5. DOI: 10.1093/Alcalc/Agv076.11 |
0.382 |
|
| 2014 |
Bernardi RE, Spanagel R. A two-injection protocol for nicotine sensitization. Behavioural Brain Research. 275: 11-4. PMID 25192633 DOI: 10.1016/J.Bbr.2014.08.048 |
0.309 |
|
| 2014 |
Bilbao A, Rieker C, Cannella N, Parlato R, Golda S, Piechota M, Korostynski M, Engblom D, Przewlocki R, Schütz G, Spanagel R, Rodriguez Parkitna J. Corrigendum: CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects. Frontiers in Behavioral Neuroscience. 8: 239. PMID 25071493 DOI: 10.3389/Fnbeh.2014.00239 |
0.379 |
|
| 2014 |
Bilbao A, Rieker C, Cannella N, Parlato R, Golda S, Piechota M, Korostynski M, Engblom D, Przewlocki R, Schütz G, Spanagel R, Parkitna JR. CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects. Frontiers in Behavioral Neuroscience. 8: 212. PMID 24966820 DOI: 10.3389/Fnbeh.2014.00212 |
0.42 |
|
| 2014 |
Bernardi RE, Spanagel R. Enhanced extinction of contextual fear conditioning in ClockΔ19 mutant mice. Behavioral Neuroscience. 128: 468-73. PMID 24865659 DOI: 10.1037/A0037020 |
0.323 |
|
| 2014 |
Vengeliene V, Bilbao A, Spanagel R. The alcohol deprivation effect model for studying relapse behavior: a comparison between rats and mice. Alcohol (Fayetteville, N.Y.). 48: 313-20. PMID 24811155 DOI: 10.1016/J.Alcohol.2014.03.002 |
0.427 |
|
| 2014 |
Spanagel R, Noori HR, Heilig M. Stress and alcohol interactions: animal studies and clinical significance. Trends in Neurosciences. 37: 219-27. PMID 24636458 DOI: 10.1016/J.Tins.2014.02.006 |
0.386 |
|
| 2014 |
Noori HR, Helinski S, Spanagel R. Cluster and meta-analyses on factors influencing stress-induced alcohol drinking and relapse in rodents. Addiction Biology. 19: 225-32. PMID 24589296 DOI: 10.1111/Adb.12125 |
0.395 |
|
| 2014 |
Bernardi RE, Spanagel R. Basal activity level in mice predicts the initial and sensitized locomotor response to nicotine only in high responders. Behavioural Brain Research. 264: 143-50. PMID 24508239 DOI: 10.1016/J.Bbr.2014.01.046 |
0.312 |
|
| 2014 |
Halbout B, Bernardi RE, Hansson AC, Spanagel R. Incubation of cocaine seeking following brief cocaine experience in mice is enhanced by mGluR1 blockade. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 1781-90. PMID 24478360 DOI: 10.1523/Jneurosci.1076-13.2014 |
0.763 |
|
| 2014 |
Jorde A, Bach P, Witt SH, Becker K, Reinhard I, Vollstädt-Klein S, Kirsch M, Hermann D, Charlet K, Beck A, Wimmer L, Frank J, Treutlein J, Spanagel R, Mann K, et al. Genetic variation in the atrial natriuretic peptide transcription factor GATA4 modulates amygdala responsiveness in alcohol dependence. Biological Psychiatry. 75: 790-7. PMID 24314346 DOI: 10.1016/J.Biopsych.2013.10.020 |
0.392 |
|
| 2014 |
Vengeliene V, Bessiere B, Pype J, Spanagel R. The effects of xenon and nitrous oxide gases on alcohol relapse. Alcoholism, Clinical and Experimental Research. 38: 557-63. PMID 24118055 DOI: 10.1111/Acer.12264 |
0.423 |
|
| 2014 |
Spanagel R, Vengeliene V, Jandeleit B, Fischer WN, Grindstaff K, Zhang X, Gallop MA, Krstew EV, Lawrence AJ, Kiefer F. Acamprosate produces its anti-relapse effects via calcium. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 783-91. PMID 24081303 DOI: 10.1038/Npp.2013.264 |
0.41 |
|
| 2014 |
Pfarr S, Meinhardt MW, Klee ML, Schönig K, Vengeliene V, Hope BT, Bartsch D, Spanagel R, Sommer WH. P.6.a.016 Losing control: excessive alcohol seeking after selective inactivation of cue-responsive neurons in the infralimbic cortex European Neuropsychopharmacology. 24. DOI: 10.1016/S0924-977X(14)71065-X |
0.352 |
|
| 2014 |
Eisenhardt M, Leixner S, Bilbao A, Spanagel R. P.6.a.007 The role of glutamatergic receptors within the dopaminergic reinforcement system in alcohol-dependent phenotypes European Neuropsychopharmacology. 24. DOI: 10.1016/S0924-977X(14)71056-9 |
0.404 |
|
| 2014 |
Olevska A, Bernardi R, Brambilla R, Spanagel R. P.2.019 The role of Ras guanine nucleotide-releasing factor 1 in cocaine self-administration European Neuropsychopharmacology. 24: S46-S47. DOI: 10.1016/S0924-977X(14)70052-5 |
0.311 |
|
| 2013 |
Spanagel R, Durstewitz D, Hansson A, Heinz A, Kiefer F, Köhr G, Matthäus F, Nöthen MM, Noori HR, Obermayer K, Rietschel M, Schloss P, Scholz H, Schumann G, Smolka M, et al. A systems medicine research approach for studying alcohol addiction. Addiction Biology. 18: 883-96. PMID 24283978 DOI: 10.1111/Adb.12109 |
0.384 |
|
| 2013 |
Bernardi RE, Spanagel R. The ClockΔ19 mutation in mice fails to alter the primary and secondary reinforcing properties of nicotine. Drug and Alcohol Dependence. 133: 733-9. PMID 24054990 DOI: 10.1016/J.Drugalcdep.2013.08.024 |
0.32 |
|
| 2013 |
Holmes A, Spanagel R, Krystal JH. Glutamatergic targets for new alcohol medications. Psychopharmacology. 229: 539-54. PMID 23995381 DOI: 10.1007/S00213-013-3226-2 |
0.419 |
|
| 2013 |
Brand I, Fliegel S, Spanagel R, Noori HR. Global ethanol-induced enhancements of monoaminergic neurotransmission: a meta-analysis study. Alcoholism, Clinical and Experimental Research. 37: 2048-57. PMID 23808660 DOI: 10.1111/Acer.12207 |
0.329 |
|
| 2013 |
Cannella N, Halbout B, Uhrig S, Evrard L, Corsi M, Corti C, Deroche-Gamonet V, Hansson AC, Spanagel R. The mGluR2/3 agonist LY379268 induced anti-reinstatement effects in rats exhibiting addiction-like behavior. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2048-56. PMID 23624743 DOI: 10.1038/Npp.2013.106 |
0.777 |
|
| 2013 |
Meinhardt MW, Hansson AC, Perreau-Lenz S, Bauder-Wenz C, Stählin O, Heilig M, Harper C, Drescher KU, Spanagel R, Sommer WH. Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 2794-806. PMID 23407939 DOI: 10.1523/Jneurosci.4062-12.2013 |
0.457 |
|
| 2013 |
Bilbao A, Blanco E, Luque-Rojas MJ, Suárez J, Palomino A, Vida M, Araos P, Bermúdez-Silva FJ, Fernández-Espejo E, Spanagel R, RodrÃguez de Fonseca F. Oleoylethanolamide dose-dependently attenuates cocaine-induced behaviours through a PPARα receptor-independent mechanism. Addiction Biology. 18: 78-87. PMID 23163925 DOI: 10.1111/Adb.12006 |
0.412 |
|
| 2013 |
Sommer W, Spanagel R. Behavioral neurobiology of alcohol addiction. Preface. Current Topics in Behavioral Neurosciences. 13: v-vii. PMID 23097780 DOI: 10.1007/978-3-642-28720-6 |
0.383 |
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| 2013 |
Vengeliene V, Noori HR, Spanagel R. The use of a novel drinkometer system for assessing pharmacological treatment effects on ethanol consumption in rats. Alcoholism, Clinical and Experimental Research. 37: E322-8. PMID 22757984 DOI: 10.1111/J.1530-0277.2012.01874.X |
0.4 |
|
| 2013 |
Spanagel R, Vengeliene V. New pharmacological treatment strategies for relapse prevention. Current Topics in Behavioral Neurosciences. 13: 583-609. PMID 22389180 DOI: 10.1007/7854_2012_205 |
0.412 |
|
| 2013 |
Lawrence A, Kim J, Chesworth R, Luikinga S, Perry C, Besheer J, Spanagel R, Parkitna JR. S06 * ARE METABOTROPIC GLUTAMATE RECEPTORS PROMISING TARGETS FOR ALCOHOL ADDICTION? Alcohol and Alcoholism. 48: i8-i9. DOI: 10.1093/alcalc/agt079 |
0.413 |
|
| 2012 |
Stacey D, Bilbao A, Maroteaux M, Jia T, Easton AC, Longueville S, Nymberg C, Banaschewski T, Barker GJ, Büchel C, Carvalho F, Conrod PJ, Desrivières S, Fauth-Bühler M, Fernandez-Medarde A, ... ... Spanagel R, et al. RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release. Proceedings of the National Academy of Sciences of the United States of America. 109: 21128-33. PMID 23223532 DOI: 10.1073/Pnas.1211844110 |
0.424 |
|
| 2012 |
Noori HR, Spanagel R, Hansson AC. Neurocircuitry for modeling drug effects. Addiction Biology. 17: 827-64. PMID 22978651 DOI: 10.1111/J.1369-1600.2012.00485.X |
0.368 |
|
| 2012 |
Frölich J, Banaschewski T, Spanagel R, Döpfner M, Lehmkuhl G. [The medical treatment of attention deficit hyperactivity disorder (ADHD) with amphetamines in children and adolescents]. Zeitschrift Fã¼R Kinder- Und Jugendpsychiatrie Und Psychotherapie. 40: 287-99; quiz 299-300. PMID 22869222 DOI: 10.1024/1422-4917/A000185 |
0.311 |
|
| 2012 |
Perreau-Lenz S, Vengeliene V, Noori HR, Merlo-Pich EV, Corsi MA, Corti C, Spanagel R. Inhibition of the casein-kinase-1-ε/δ/ prevents relapse-like alcohol drinking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2121-31. PMID 22549116 DOI: 10.1038/Npp.2012.62 |
0.436 |
|
| 2012 |
Whelan R, Conrod PJ, Poline JB, Lourdusamy A, Banaschewski T, Barker GJ, Bellgrove MA, Büchel C, Byrne M, Cummins TD, Fauth-Bühler M, Flor H, Gallinat J, Heinz A, Ittermann B, ... ... Spanagel R, et al. Adolescent impulsivity phenotypes characterized by distinct brain networks. Nature Neuroscience. 15: 920-5. PMID 22544311 DOI: 10.1038/Nn.3092 |
0.474 |
|
| 2012 |
Brand T, Spanagel R, Schneider M. Decreased reward sensitivity in rats from the Fischer344 strain compared to Wistar rats is paralleled by differences in endocannabinoid signaling. Plos One. 7: e31169. PMID 22347447 DOI: 10.1371/Journal.Pone.0031169 |
0.305 |
|
| 2012 |
Karlsson RM, Adermark L, Molander A, Perreau-Lenz S, Singley E, Solomon M, Holmes A, Tanaka K, Lovinger DM, Spanagel R, Heilig M. Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST. Neuropharmacology. 63: 181-9. PMID 22342743 DOI: 10.1016/J.Neuropharm.2012.01.027 |
0.331 |
|
| 2012 |
Nees F, Tzschoppe J, Patrick CJ, Vollstädt-Klein S, Steiner S, Poustka L, Banaschewski T, Barker GJ, Büchel C, Conrod PJ, Garavan H, Heinz A, Gallinat J, Lathrop M, Mann K, ... ... Spanagel R, et al. Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 986-95. PMID 22113088 DOI: 10.1038/Npp.2011.282 |
0.387 |
|
| 2012 |
Molander A, Vengeliene V, Heilig M, Wurst W, Deussing JM, Spanagel R. Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1047-56. PMID 22113086 DOI: 10.1038/Npp.2011.297 |
0.42 |
|
| 2012 |
Schneider S, Peters J, Bromberg U, Brassen S, Miedl SF, Banaschewski T, Barker GJ, Conrod P, Flor H, Garavan H, Heinz A, Ittermann B, Lathrop M, Loth E, Mann K, ... ... Spanagel R, et al. Risk taking and the adolescent reward system: a potential common link to substance abuse. The American Journal of Psychiatry. 169: 39-46. PMID 21955931 DOI: 10.1176/Appi.Ajp.2011.11030489 |
0.314 |
|
| 2012 |
Hermann D, Weber-Fahr W, Sartorius A, Hoerst M, Frischknecht U, Tunc-Skarka N, Perreau-Lenz S, Hansson AC, Krumm B, Kiefer F, Spanagel R, Mann K, Ende G, Sommer WH. Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats. Biological Psychiatry. 71: 1015-21. PMID 21907974 DOI: 10.1016/J.Biopsych.2011.07.034 |
0.409 |
|
| 2012 |
Weber T, Bilbao A, Berger S, Giros B, Spanagel R, Bartsch D. P.6.b.002 Compulsive-impulsive alcohol consumption in serotonin deficient vesicular monoamine transporter 2 (Vmat2) knockout mice European Neuropsychopharmacology. 22: S395. DOI: 10.1016/S0924-977X(12)70615-6 |
0.358 |
|
| 2011 |
Helinski S, Spanagel R. Publication trends in addiction research. Addiction Biology. 16: 532-9. PMID 21929709 DOI: 10.1111/J.1369-1600.2011.00388.X |
0.329 |
|
| 2011 |
Dong L, Bilbao A, Laucht M, Henriksson R, Yakovleva T, Ridinger M, Desrivieres S, Clarke TK, Lourdusamy A, Smolka MN, Cichon S, Blomeyer D, Treutlein J, Perreau-Lenz S, Witt S, ... ... Spanagel R, et al. Effects of the circadian rhythm gene period 1 (per1) on psychosocial stress-induced alcohol drinking. The American Journal of Psychiatry. 168: 1090-8. PMID 21828288 DOI: 10.1176/Appi.Ajp.2011.10111579 |
0.369 |
|
| 2011 |
Zink M, Ferbert T, Frank ST, Seufert P, Gebicke-Haerter PJ, Spanagel R. Perinatal exposure to alcohol disturbs spatial learning and glutamate transmission-related gene expression in the adult hippocampus. The European Journal of Neuroscience. 34: 457-68. PMID 21722212 DOI: 10.1111/J.1460-9568.2011.07776.X |
0.36 |
|
| 2011 |
Schumann G, Coin LJ, Lourdusamy A, Charoen P, Berger KH, Stacey D, Desrivières S, Aliev FA, Khan AA, Amin N, Aulchenko YS, Bakalkin G, Bakker SJ, Balkau B, Beulens JW, ... ... Spanagel R, et al. Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proceedings of the National Academy of Sciences of the United States of America. 108: 7119-24. PMID 21471458 DOI: 10.1073/Pnas.1017288108 |
0.388 |
|
| 2011 |
Stickel F, Buch S, Lau K, Meyer zu Schwabedissen H, Berg T, Ridinger M, Rietschel M, Schafmayer C, Braun F, Hinrichsen H, Günther R, Arlt A, Seeger M, Müller S, Seitz HK, ... ... Spanagel R, et al. Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians. Hepatology (Baltimore, Md.). 53: 86-95. PMID 21254164 DOI: 10.1002/Hep.24017 |
0.345 |
|
| 2011 |
Klugmann M, Klippenstein V, Leweke FM, Spanagel R, Schneider M. Cannabinoid exposure in pubertal rats increases spontaneous ethanol consumption and NMDA receptor associated protein levels. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 14: 505-17. PMID 21211107 DOI: 10.1017/S1461145710001562 |
0.377 |
|
| 2011 |
Halbout B, Perreau-Lenz S, Dixon CI, Stephens DN, Spanagel R. Per1(Brdm1) mice self-administer cocaine and reinstate cocaine-seeking behaviour following extinction. Behavioural Pharmacology. 22: 76-80. PMID 21127416 DOI: 10.1097/Fbp.0B013E328341E9Ca |
0.778 |
|
| 2011 |
Kiefer F, Witt SH, Frank J, Richter A, Treutlein J, Lemenager T, Nöthen MM, Cichon S, Batra A, Berner M, Wodarz N, Zimmermann US, Spanagel R, Wiedemann K, Smolka MN, et al. Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate. The Pharmacogenomics Journal. 11: 368-74. PMID 20585342 DOI: 10.1038/Tpj.2010.51 |
0.375 |
|
| 2011 |
Zink M, Ferbert T, Frank ST, Seufert P, Gebicke-Härter PJ, Spanagel R. P02-316 - Perinatal exposure to alcohol disturbs spatial learning and glutamatergic neurotransmission in the hippocampus European Psychiatry. 26: 912-912. DOI: 10.1016/S0924-9338(11)72617-7 |
0.359 |
|
| 2010 |
Schumann G, Loth E, Banaschewski T, Barbot A, Barker G, Büchel C, Conrod PJ, Dalley JW, Flor H, Gallinat J, Garavan H, Heinz A, Itterman B, Lathrop M, Mallik C, ... ... Spanagel R, et al. The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology. Molecular Psychiatry. 15: 1128-39. PMID 21102431 DOI: 10.1038/Mp.2010.4 |
0.466 |
|
| 2010 |
Spanagel R, Bartsch D, Brors B, Dahmen N, Deussing J, Eils R, Ende G, Gallinat J, Gebicke-Haerter P, Heinz A, Kiefer F, Jäger W, Mann K, Matthäus F, Nöthen M, et al. An integrated genome research network for studying the genetics of alcohol addiction. Addiction Biology. 15: 369-79. PMID 21040237 DOI: 10.1111/J.1369-1600.2010.00276.X |
0.406 |
|
| 2010 |
Umhau JC, Momenan R, Schwandt ML, Singley E, Lifshitz M, Doty L, Adams LJ, Vengeliene V, Spanagel R, Zhang Y, Shen J, George DT, Hommer D, Heilig M. Effect of acamprosate on magnetic resonance spectroscopy measures of central glutamate in detoxified alcohol-dependent individuals: a randomized controlled experimental medicine study. Archives of General Psychiatry. 67: 1069-77. PMID 20921123 DOI: 10.1001/Archgenpsychiatry.2010.125 |
0.383 |
|
| 2010 |
Novak M, Halbout B, O'Connor EC, Rodriguez Parkitna J, Su T, Chai M, Crombag HS, Bilbao A, Spanagel R, Stephens DN, Schütz G, Engblom D. Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11973-82. PMID 20826661 DOI: 10.1523/Jneurosci.2550-10.2010 |
0.79 |
|
| 2010 |
Friemel CM, Spanagel R, Schneider M. Reward sensitivity for a palatable food reward peaks during pubertal developmental in rats. Frontiers in Behavioral Neuroscience. 4. PMID 20700386 DOI: 10.3389/Fnbeh.2010.00039 |
0.36 |
|
| 2010 |
Vengeliene V, Leonardi-Essmann F, Sommer WH, Marston HM, Spanagel R. Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats. Biological Psychiatry. 68: 704-11. PMID 20655511 DOI: 10.1016/J.Biopsych.2010.05.029 |
0.448 |
|
| 2010 |
Brunk I, Sanchis-Segura C, Blex C, Perreau-Lenz S, Bilbao A, Spanagel R, Ahnert-Hilger G. Amphetamine regulates NR2B expression in Go2α knockout mice and thereby sustains behavioral sensitization. Journal of Neurochemistry. 115: 234-46. PMID 20649838 DOI: 10.1111/J.1471-4159.2010.06921.X |
0.411 |
|
| 2010 |
Spanagel R. Are metabotropic glutamate receptors promising targets for the treatment of alcoholism? Biological Psychiatry. 67: 798-9. PMID 20381698 DOI: 10.1016/J.Biopsych.2010.03.003 |
0.364 |
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| 2010 |
Parkitna JR, Bilbao A, Rieker C, Engblom D, Piechota M, Nordheim A, Spanagel R, Schütz G. Loss of the serum response factor in the dopamine system leads to hyperactivity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 2427-35. PMID 20223941 DOI: 10.1096/Fj.09-151423 |
0.31 |
|
| 2010 |
Schneider M, Heise V, Spanagel R. Differential involvement of the opioid receptor antagonist naloxone in motivational and hedonic aspects of reward. Behavioural Brain Research. 208: 466-72. PMID 20035797 DOI: 10.1016/J.Bbr.2009.12.013 |
0.327 |
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| 2010 |
Mutschler J, Bilbao A, von der Goltz C, Demiralay C, Jahn H, Wiedemann K, Spanagel R, Kiefer F. Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors. Alcohol and Alcoholism (Oxford, Oxfordshire). 45: 13-6. PMID 19828462 DOI: 10.1093/Alcalc/Agp065 |
0.414 |
|
| 2010 |
Stickel F, Buch S, Lau K, Schwabedissen HMz, Berg T, Ridinger M, Wiegandt S, Rietschel M, Schafmayer C, Braun F, Hinrichsen H, Günther R, Arlt A, Seeger M, Mueller S, ... ... Spanagel R, et al. 1183 Genetic Variation In The Pnpla3 Gene Is Associated With Alcoholic Liver Injury In Caucasians Journal of Hepatology. 52. DOI: 10.1016/S0168-8278(10)61184-1 |
0.31 |
|
| 2009 |
Vengeliene V, Celerier E, Chaskiel L, Penzo F, Spanagel R. Compulsive alcohol drinking in rodents. Addiction Biology. 14: 384-96. PMID 19740366 DOI: 10.1111/J.1369-1600.2009.00177.X |
0.413 |
|
| 2009 |
Zink M, Araç G, Frank ST, Gass P, Gebicke-Härter PJ, Spanagel R. Perinatal exposure to alcohol reduces the expression of complexins I and II. Neurotoxicology and Teratology. 31: 400-5. PMID 19671442 DOI: 10.1016/J.Ntt.2009.08.001 |
0.347 |
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| 2009 |
Mameli M, Halbout B, Creton C, Engblom D, Parkitna JR, Spanagel R, Lüscher C. Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Nature Neuroscience. 12: 1036-41. PMID 19597494 DOI: 10.1038/Nn.2367 |
0.763 |
|
| 2009 |
Treutlein J, Cichon S, Ridinger M, Wodarz N, Soyka M, Zill P, Maier W, Moessner R, Gaebel W, Dahmen N, Fehr C, Scherbaum N, Steffens M, Ludwig KU, Frank J, ... ... Spanagel R, et al. Genome-wide association study of alcohol dependence. Archives of General Psychiatry. 66: 773-84. PMID 19581569 DOI: 10.1001/Archgenpsychiatry.2009.83 |
0.36 |
|
| 2009 |
Perreau-Lenz S, Zghoul T, de Fonseca FR, Spanagel R, Bilbao A. Circadian regulation of central ethanol sensitivity by the mPer2 gene. Addiction Biology. 14: 253-9. PMID 19523042 DOI: 10.1111/J.1369-1600.2009.00165.X |
0.359 |
|
| 2009 |
Matthäus F, Smith VA, Fogtman A, Sommer WH, Leonardi-Essmann F, Lourdusamy A, Reimers MA, Spanagel R, Gebicke-Haerter PJ. Interactive molecular networks obtained by computer-aided conversion of microarray data from brains of alcohol-drinking rats. Pharmacopsychiatry. 42: S118-28. PMID 19434550 DOI: 10.1055/S-0029-1216348 |
0.376 |
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| 2009 |
von der Goltz C, Vengeliene V, Bilbao A, Perreau-Lenz S, Pawlak CR, Kiefer F, Spanagel R. Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories. Psychopharmacology. 205: 389-97. PMID 19418040 DOI: 10.1007/S00213-009-1544-1 |
0.402 |
|
| 2009 |
Spanagel R. Alcoholism: a systems approach from molecular physiology to addictive behavior. Physiological Reviews. 89: 649-705. PMID 19342616 DOI: 10.1152/Physrev.00013.2008 |
0.413 |
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| 2009 |
Mutschler J, Bilbao A, der Goltz Cv, Demiralay C, Jahn H, Wiedemann K, Spanagel R, Kiefer F. Stress-induced alcohol drinking and withdrawal in mice lacking functional natriruetic peptide-A receptors Pharmacopsychiatry. 42. DOI: 10.1055/S-0029-1240181 |
0.38 |
|
| 2009 |
Halbout B, Bilbao A, Parkitna JR, Schütz G, Spanagel R. P.4.04 Specific deletion of AMPA-R GluR1 subunits in D1 expressing neurons: cocaine-addiction related behavioural consequences European Neuropsychopharmacology. 19. DOI: 10.1016/S0924-977X(09)70094-X |
0.742 |
|
| 2009 |
von der Goltz C, Vengeliene V, Kiefer F, Spanagel R. P01-84 Disrupting reconsolidation of alcohol memories reduces cue-induced alcohol seeking behavior in rats European Psychiatry. 24: S472. DOI: 10.1016/S0924-9338(09)70705-9 |
0.414 |
|
| 2009 |
von der Goltz C, Vengeliene V, Kiefer F, Spanagel R. S64-03 Pharmacological disruption of alcohol-related memories - therapeutic impact of the theory of memory reconsolidation European Psychiatry. 24: S307. DOI: 10.1016/S0924-9338(09)70540-1 |
0.402 |
|
| 2008 |
Bilbao A, Parkitna JR, Engblom D, Perreau-Lenz S, Sanchis-Segura C, Schneider M, Konopka W, Westphal M, Breen G, Desrivieres S, Klugmann M, Guindalini C, Vallada H, Laranjeira R, de Fonseca FR, ... ... Spanagel R, et al. Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. Proceedings of the National Academy of Sciences of the United States of America. 105: 17549-54. PMID 19001277 DOI: 10.1073/Pnas.0803959105 |
0.406 |
|
| 2008 |
Vengeliene V, Kiefer F, Spanagel R. D-cycloserine facilitates extinction of conditioned alcohol-seeking behaviour in rats. Alcohol and Alcoholism (Oxford, Oxfordshire). 43: 626-9. PMID 18945754 DOI: 10.1093/Alcalc/Agn067 |
0.418 |
|
| 2008 |
Engblom D, Bilbao A, Sanchis-Segura C, Dahan L, Perreau-Lenz S, Balland B, Parkitna JR, Luján R, Halbout B, Mameli M, Parlato R, Sprengel R, Lüscher C, Schütz G, Spanagel R. Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. Neuron. 59: 497-508. PMID 18701074 DOI: 10.1016/J.Neuron.2008.07.010 |
0.768 |
|
| 2008 |
Wiens F, Zitzmann A, Lachance MA, Yegles M, Pragst F, Wurst FM, von Holst D, Guan SL, Spanagel R. Chronic intake of fermented floral nectar by wild treeshrews. Proceedings of the National Academy of Sciences of the United States of America. 105: 10426-31. PMID 18663222 DOI: 10.1073/Pnas.0801628105 |
0.383 |
|
| 2008 |
Schumann G, Johann M, Frank J, Preuss U, Dahmen N, Laucht M, Rietschel M, Rujescu D, Lourdusamy A, Clarke TK, Krause K, Dyer A, Depner M, Wellek S, Treutlein J, ... ... Spanagel R, et al. Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. Archives of General Psychiatry. 65: 826-38. PMID 18606955 DOI: 10.1001/Archpsyc.65.7.826 |
0.407 |
|
| 2008 |
Brunk I, Blex C, Sanchis-Segura C, Sternberg J, Perreau-Lenz S, Bilbao A, Hörtnagl H, Baron J, Juranek J, Laube G, Birnbaumer L, Spanagel R, Ahnert-Hilger G. Deletion of Go2alpha abolishes cocaine-induced behavioral sensitization by disturbing the striatal dopamine system. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3736-46. PMID 18606864 DOI: 10.1096/Fj.08-111245 |
0.398 |
|
| 2008 |
Perreau-Lenz S, Spanagel R. The effects of drugs of abuse on clock genes. Drug News & Perspectives. 21: 211-7. PMID 18560620 DOI: 10.1358/Dnp.2008.21.4.1213350 |
0.375 |
|
| 2008 |
Mann K, Kiefer F, Spanagel R, Littleton J. Acamprosate: recent findings and future research directions. Alcoholism, Clinical and Experimental Research. 32: 1105-10. PMID 18540918 DOI: 10.1111/J.1530-0277.2008.00690.X |
0.433 |
|
| 2008 |
Hampp G, Ripperger JA, Houben T, Schmutz I, Blex C, Perreau-Lenz S, Brunk I, Spanagel R, Ahnert-Hilger G, Meijer JH, Albrecht U. Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood. Current Biology : Cb. 18: 678-83. PMID 18439826 DOI: 10.1016/J.Cub.2008.04.012 |
0.336 |
|
| 2008 |
Raeder H, Holter SM, Hartmann AM, Spanagel R, Moller HJ, Rujescu D. Expression of N-methyl-d-aspartate (NMDA) receptor subunits and splice variants in an animal model of long-term voluntary alcohol self-administration. Drug and Alcohol Dependence. 96: 16-21. PMID 18358639 DOI: 10.1016/J.Drugalcdep.2007.12.013 |
0.393 |
|
| 2008 |
Vengeliene V, Bilbao A, Molander A, Spanagel R. Neuropharmacology of alcohol addiction. British Journal of Pharmacology. 154: 299-315. PMID 18311194 DOI: 10.1038/Bjp.2008.30 |
0.414 |
|
| 2008 |
Spanagel R, Kiefer F. Drugs for relapse prevention of alcoholism: ten years of progress. Trends in Pharmacological Sciences. 29: 109-15. PMID 18262663 DOI: 10.1016/J.Tips.2007.12.005 |
0.415 |
|
| 2008 |
Frank ST, Krumm B, Spanagel R. Cocaine-induced dopamine overflow within the nucleus accumbens measured by in vivo microdialysis: a meta-analysis. Synapse (New York, N.Y.). 62: 243-52. PMID 18236471 DOI: 10.1002/Syn.20489 |
0.378 |
|
| 2008 |
Pawlak CR, Sanchis-Segura C, Soewarto D, Wagner S, Hrabé de Angelis M, Spanagel R. A phenotype-driven ENU mutagenesis screen for the identification of dominant mutations involved in alcohol consumption. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 19: 77-84. PMID 18213483 DOI: 10.1007/S00335-007-9087-4 |
0.397 |
|
| 2008 |
Mutschler J, Bilbao A, von der Goltz C, Jahn H, Spanagel R, Wiedemann K, Kiefer F. Increased alcohol sensitivity to stress in mice lacking a functional natriuretic peptide-A receptor European Psychiatry. 23: S254. DOI: 10.1016/J.Eurpsy.2008.01.501 |
0.354 |
|
| 2007 |
Schneider M, Spanagel R, Zhang SJ, Bading H, Klugmann M. Adeno-associated virus (AAV)-mediated suppression of Ca2+/calmodulin kinase IV activity in the nucleus accumbens modulates emotional behaviour in mice. Bmc Neuroscience. 8: 105. PMID 18053176 DOI: 10.1186/1471-2202-8-105 |
0.311 |
|
| 2007 |
Vengeliene V, Heidbreder CA, Spanagel R. The effects of lamotrigine on alcohol seeking and relapse. Neuropharmacology. 53: 951-7. PMID 17976664 DOI: 10.1016/J.Neuropharm.2007.09.006 |
0.425 |
|
| 2007 |
Perreau-Lenz S, Zghoul T, Spanagel R. Clock genes running amok. Clock genes and their role in drug addiction and depression. Embo Reports. 8: S20-3. PMID 17726437 DOI: 10.1038/Sj.Embor.7401016 |
0.372 |
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| 2007 |
Bottlender M, Spanagel R, Soyka M. [One drink, one drunk--controlled drinking by alcoholics? 3-year-outcome after intensive outpatient treatment]. Psychotherapie, Psychosomatik, Medizinische Psychologie. 57: 32-8. PMID 17357031 DOI: 10.1055/S-2006-951918 |
0.378 |
|
| 2007 |
Sanchis-Segura C, Cline B, Jurd R, Rudolph U, Spanagel R. Etomidate and propofol-hyposensitive GABAA receptor beta3(N265M) mice show little changes in acute alcohol sensitivity but enhanced tolerance and withdrawal. Neuroscience Letters. 416: 275-8. PMID 17350761 DOI: 10.1016/J.Neulet.2007.02.024 |
0.373 |
|
| 2007 |
Füllgrabe MW, Vengeliene V, Spanagel R. Influence of age at drinking onset on the alcohol deprivation effect and stress-induced drinking in female rats. Pharmacology, Biochemistry, and Behavior. 86: 320-6. PMID 17098280 DOI: 10.1016/J.Pbb.2006.10.004 |
0.386 |
|
| 2007 |
Zghoul T, Abarca C, Sanchis-Segura C, Albrecht U, Schumann G, Spanagel R. Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1(Brdm1) mutant mice. Psychopharmacology. 190: 13-9. PMID 17051414 DOI: 10.1007/S00213-006-0592-Z |
0.427 |
|
| 2007 |
Spanagel R. Neurobiology of Addiction Addiction. 102: 493-493. DOI: 10.1111/J.1360-0443.2007.01786.X |
0.387 |
|
| 2007 |
Mutschler J, Bilbao A, Goltz C, Jahn H, Spanagel R, Wiedeman K, Kiefer F. Elevated alcohol consumption in mice lacking functional natriruetic peptide-A receptor Pharmacopsychiatry. 40. DOI: 10.1055/S-2007-991821 |
0.384 |
|
| 2006 |
Vengeliene V, Leonardi-Essmann F, Perreau-Lenz S, Gebicke-Haerter P, Drescher K, Gross G, Spanagel R. The dopamine D3 receptor plays an essential role in alcohol-seeking and relapse. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2223-33. PMID 17077299 DOI: 10.1096/Fj.06-6110Com |
0.451 |
|
| 2006 |
Kiefer F, Spanagel R. Measuring alcohol consumption in man--it is time for a change. Addiction (Abingdon, England). 101: 1215-6; author reply. PMID 16869854 DOI: 10.1111/J.1360-0443.2006.01541.X |
0.352 |
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| 2006 |
Sanchis-Segura C, Spanagel R. Behavioural assessment of drug reinforcement and addictive features in rodents: an overview. Addiction Biology. 11: 2-38. PMID 16759333 DOI: 10.1111/J.1369-1600.2006.00012.X |
0.317 |
|
| 2006 |
Treutlein J, Kissling C, Frank J, Wiemann S, Dong L, Depner M, Saam C, Lascorz J, Soyka M, Preuss UW, Rujescu D, Skowronek MH, Rietschel M, Spanagel R, Heinz A, et al. Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples. Molecular Psychiatry. 11: 594-602. PMID 16550213 DOI: 10.1038/Sj.Mp.4001813 |
0.395 |
|
| 2006 |
Sanchis-Segura C, Borchardt T, Vengeliene V, Zghoul T, Bachteler D, Gass P, Sprengel R, Spanagel R. Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 1231-8. PMID 16436610 DOI: 10.1523/Jneurosci.4237-05.2006 |
0.456 |
|
| 2005 |
Spanagel R, Heilig M. Addiction and its brain science. Addiction (Abingdon, England). 100: 1813-22. PMID 16367982 DOI: 10.1111/J.1360-0443.2005.01260.X |
0.363 |
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| 2005 |
Spanagel R, Rosenwasser AM, Schumann G, Sarkar DK. Alcohol consumption and the body's biological clock. Alcoholism, Clinical and Experimental Research. 29: 1550-7. PMID 16156052 DOI: 10.1097/01.Alc.0000175074.70807.Fd |
0.427 |
|
| 2005 |
Siegmund S, Vengeliene V, Singer MV, Spanagel R. Influence of age at drinking onset on long-term ethanol self-administration with deprivation and stress phases. Alcoholism, Clinical and Experimental Research. 29: 1139-45. PMID 16046868 DOI: 10.1097/01.Alc.0000171928.40418.46 |
0.402 |
|
| 2005 |
Vengeliene V, Bachteler D, Danysz W, Spanagel R. The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect. Neuropharmacology. 48: 822-9. PMID 15829254 DOI: 10.1016/J.Neuropharm.2005.01.002 |
0.431 |
|
| 2005 |
Zink M, Spanagel R. Ethanol induces GAD67 and VGAT in slice cultures of newborn rat cerebral cortex. Neuroreport. 16: 377-80. PMID 15729141 DOI: 10.1097/00001756-200503150-00014 |
0.303 |
|
| 2005 |
Vengeliene V, Vollmayr B, Henn FA, Spanagel R. Voluntary alcohol intake in two rat lines selectively bred for learned helpless and non-helpless behavior. Psychopharmacology. 178: 125-32. PMID 15719228 DOI: 10.1007/S00213-004-2013-5 |
0.389 |
|
| 2005 |
Bachteler D, Economidou D, Danysz W, Ciccocioppo R, Spanagel R. The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 1104-10. PMID 15668725 DOI: 10.1038/Sj.Npp.1300657 |
0.393 |
|
| 2005 |
Spanagel R, Pendyala G, Abarca C, Zghoul T, Sanchis-Segura C, Magnone MC, Lascorz J, Depner M, Holzberg D, Soyka M, Schreiber S, Matsuda F, Lathrop M, Schumann G, Albrecht U. The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nature Medicine. 11: 35-42. PMID 15608650 DOI: 10.1038/Nm1163 |
0.421 |
|
| 2005 |
Spanagel R, Pendyala G, Abarca C, Zghoul T, Sanchis-Segura C, Magnone MC, Lascorz J, Depner M, Holzberg D, Soyka M, Schreiber S, Matsuda F, Lathrop M, Schumann G, Albrecht U. Erratum: The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption Nature Medicine. 11: 233-233. DOI: 10.1038/Nm0205-233C |
0.373 |
|
| 2004 |
Werner C, Raivich G, Cowen M, Strekalova T, Sillaber I, Buters JT, Spanagel R, Hofmann F. Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol. The European Journal of Neuroscience. 20: 3498-506. PMID 15610182 DOI: 10.1111/J.1460-9568.2004.03793.X |
0.406 |
|
| 2004 |
Zink M, Schmitt A, Vengeliene V, Henn FA, Spanagel R. Ethanol induces expression of the glutamate transporters EAAT1 and EAAT2 in organotypic cortical slice cultures. Alcoholism, Clinical and Experimental Research. 28: 1752-7. PMID 15547463 DOI: 10.1097/01.Alc.0000145810.12545.B3 |
0.325 |
|
| 2004 |
Schroff KC, Cowen MS, Koch S, Spanagel R. Strain-specific responses of inbred mice to ethanol following food shortage. Addiction Biology. 9: 265-71. PMID 15511722 DOI: 10.1111/J.1369-1600.2004.Tb00542.X |
0.325 |
|
| 2004 |
Littleton JM, De Witte P, Litten R, Gessa GL, Spanagel R, Kranzler H, Lehert P, Johnson B, Saunders J, Berglund M, Harris A, Anton R, Mann K. Challenges to medications development in treating alcohol dependence: an international perspective. Alcohol and Alcoholism (Oxford, Oxfordshire). 39: 271-5. PMID 15208155 DOI: 10.1093/Alcalc/Agh067 |
0.324 |
|
| 2004 |
Sanchis-Segura C, Cline BH, Marsicano G, Lutz B, Spanagel R. Reduced sensitivity to reward in CB1 knockout mice. Psychopharmacology. 176: 223-32. PMID 15083252 DOI: 10.1007/S00213-004-1877-8 |
0.329 |
|
| 2004 |
Bäckström P, Bachteler D, Koch S, Hyytiä P, Spanagel R. mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 921-8. PMID 14735132 DOI: 10.1038/Sj.Npp.1300381 |
0.398 |
|
| 2004 |
Schumann G, Preuss U, Rujescu D, Depner M, Saam C, Wieman S, Wellek S, Szegedi A, Bondy B, M??ller A, Kissling C, Lascorz J, Soyka M, Poustka A, Mann K, ... ... Spanagel R, et al. GENETIC ANALYSIS OF CIRCADIAN RHYTHM GENES PER1 AND PER2 IN PATIENTS WITH ALCOHOL DEPENDENCE. Alcoholism: Clinical & Experimental Research. 28: 61A. DOI: 10.1097/00000374-200408002-00324 |
0.349 |
|
| 2004 |
Spanagel R, Leonardi-Essmann F, Gebicke-Haerter PJ. MICROARRAY-BASED GENE EXPRESSION PROFILING IN LONG-TERM ALCOHOL DRINKING AA-, P-, AND HAD-RATS. Alcoholism: Clinical & Experimental Research. 28: 57A. DOI: 10.1097/00000374-200408002-00301 |
0.36 |
|
| 2004 |
Perreau-Lenz S, Zghoul T, Vengeliene V, Bachteler D, Leonardi F, Spanagel R. EFFICACY OF ADDITIONAL PSYCHOTHERAPY FOR THE ROLE OF DOPAMINE D3 RECEPTORS IN ALCOHOL CRAVING AND RELAPSE. Alcoholism: Clinical & Experimental Research. 28: 39A. DOI: 10.1097/00000374-200408002-00197 |
0.392 |
|
| 2004 |
Brandt R, Jesenofsky R, Leonardi F, Feick P, Ringel J, Singer MV, Eils R, Brors B, Spanagel R, L??hr M. DIFFERENTIAL GENE EXPRESSION IN THE ALCOHOL TARGET ORGANS LIVER AND PANCREAS OF WISTAR RATS USING DNA CHIP TECHNOLOGY. Alcoholism: Clinical & Experimental Research. 28: 28A. DOI: 10.1097/00000374-200408002-00128 |
0.317 |
|
| 2004 |
Leonardi-Essmann F, Vengeliene V, Gass P, Gebicke-Haerter P, Spanagel R. C-FOS MAPPING AND GENE EXPRESSION PROFILES IN RATS UNDERGOING ALCOHOL DEPRIVATION EFFECT. Alcoholism: Clinical & Experimental Research. 28: 16A. DOI: 10.1097/00000374-200408002-00056 |
0.348 |
|
| 2004 |
Bachteler D, Economidou D, Ciccocioppo R, Spanagel R. ACAMPROSATE, BUT NOT NERAMEXANE, REDUCES CUE-INDUCED REINSTATEMENT OF ETHANOL-SEEKING BEHAVIOR. Alcoholism: Clinical & Experimental Research. 28: 15A. DOI: 10.1097/00000374-200408002-00052 |
0.321 |
|
| 2004 |
Sanchis-Segura C, Zghoul T, Sprengel R, Spanagel R. GLUR-C KNOCKOUT MICE DO NOT EXHIBIT AN ALCOHOL DEPRIVATION EFFECT AND SHOW LESS ALCOHOL SEEKING BEHAVIOUR. Alcoholism: Clinical & Experimental Research. 28: 15A. DOI: 10.1097/00000374-200408002-00050 |
0.401 |
|
| 2003 |
Schumann G, Rujescu D, Kissling C, Soyka M, Dahmen N, Preuss UW, Wieman S, Depner M, Wellek S, Lascorz J, Bondy B, Giegling I, Anghelescu I, Cowen MS, Poustka A, ... Spanagel R, et al. Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts. Biological Psychiatry. 54: 1422-6. PMID 14675807 DOI: 10.1016/S0006-3223(03)00635-8 |
0.369 |
|
| 2003 |
Cowen MS, Schumann G, Yagi T, Spanagel R. Role of Fyn tyrosine kinase in ethanol consumption by mice. Alcoholism, Clinical and Experimental Research. 27: 1213-9. PMID 12966312 DOI: 10.1097/01.Alc.0000081630.14159.02 |
0.375 |
|
| 2003 |
Spanagel R. [The role of the glutamatergic system in alcohol addiction]. Fortschritte Der Neurologie-Psychiatrie. 71: S33-5. PMID 12947541 DOI: 10.1055/s-2003-40503 |
0.338 |
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| 2003 |
Vengeliene V, Siegmund S, Singer MV, Sinclair JD, Li TK, Spanagel R. A comparative study on alcohol-preferring rat lines: effects of deprivation and stress phases on voluntary alcohol intake. Alcoholism, Clinical and Experimental Research. 27: 1048-54. PMID 12878910 DOI: 10.1097/01.Alc.0000075829.81211.0C |
0.402 |
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| 2003 |
Cowen MS, Schroff KC, Gass P, Sprengel R, Spanagel R. Neurobehavioral effects of alcohol in AMPA receptor subunit (GluR1) deficient mice. Neuropharmacology. 45: 325-33. PMID 12871650 DOI: 10.1016/S0028-3908(03)00174-6 |
0.385 |
|
| 2003 |
Spanagel R. Alcohol addiction research: from animal models to clinics. Best Practice & Research. Clinical Gastroenterology. 17: 507-18. PMID 12828952 DOI: 10.1016/S1521-6918(03)00031-3 |
0.407 |
|
| 2003 |
Deroche-Gamonet V, Sillaber I, Aouizerate B, Izawa R, Jaber M, Ghozland S, Kellendonk C, Le Moal M, Spanagel R, Schütz G, Tronche F, Piazza PV. The glucocorticoid receptor as a potential target to reduce cocaine abuse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4785-90. PMID 12805318 DOI: 10.1523/Jneurosci.23-11-04785.2003 |
0.416 |
|
| 2003 |
Schumann G, Spanagel R, Mann K. Candidate genes for alcohol dependence: animal studies. Alcoholism, Clinical and Experimental Research. 27: 880-8. PMID 12766634 DOI: 10.1097/01.Alc.0000065437.18136.86 |
0.389 |
|
| 2003 |
Schumann G, Rujescu D, Szegedi A, Singer P, Wiemann S, Wellek S, Giegling I, Klawe C, Anghelescu I, Heinz A, Spanagel R, Mann K, Henn FA, Dahmen N. No association of alcohol dependence with a NMDA-receptor 2B gene variant. Molecular Psychiatry. 8: 11-2. PMID 12556902 DOI: 10.1038/Sj.Mp.4001245 |
0.367 |
|
| 2003 |
Spanagel R, Sanchis-Segura C. The use of transgenic mice to study addictive behavior Clinical Neuroscience Research. 3: 325-331. DOI: 10.1016/S1566-2772(03)00094-X |
0.363 |
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| 2002 |
Spanagel R, Siegmund S, Cowen M, Schroff KC, Schumann G, Fiserova M, Sillaber I, Wellek S, Singer M, Putzke J. The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8676-83. PMID 12351742 DOI: 10.1523/Jneurosci.22-19-08676.2002 |
0.412 |
|
| 2002 |
Kirschke C, Schadrack J, Zieglgänsberger W, Spanagel R. Effects of morphine withdrawal on micro-opioid receptor-stimulated guanylyl 5'-[gamma-[35S]thio]-triphosphate autoradiography in rat brain. European Journal of Pharmacology. 446: 43-51. PMID 12098584 DOI: 10.1016/S0014-2999(02)01763-6 |
0.309 |
|
| 2002 |
Abarca C, Albrecht U, Spanagel R. Cocaine sensitization and reward are under the influence of circadian genes and rhythm. Proceedings of the National Academy of Sciences of the United States of America. 99: 9026-30. PMID 12084940 DOI: 10.1073/Pnas.142039099 |
0.396 |
|
| 2002 |
Henniger MS, Spanagel R, Wigger A, Landgraf R, Hölter SM. Alcohol self-administration in two rat lines selectively bred for extremes in anxiety-related behavior. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 26: 729-36. PMID 12007743 DOI: 10.1016/S0893-133X(01)00408-0 |
0.413 |
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| 2002 |
Sillaber I, Rammes G, Zimmermann S, Mahal B, Zieglgänsberger W, Wurst W, Holsboer F, Spanagel R. Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. Science (New York, N.Y.). 296: 931-3. PMID 11988580 DOI: 10.1126/Science.1069836 |
0.412 |
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| 2001 |
Boening JA, Lesch OM, Spanagel R, Wolffgramm J, Narita M, Sinclair D, Mason BJ, Wiesbeck GA. Pharmacological relapse prevention in alcohol dependence: from animal models to clinical trials. Alcoholism, Clinical and Experimental Research. 25: 127S-131S. PMID 11391061 DOI: 10.1111/J.1530-0277.2001.Tb02386.X |
0.431 |
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| 2001 |
Li TK, Spanagel R, Colombo G, McBride WJ, Porrino LJ, Suzuki T, Rodd-Henricks ZA. Alcohol reinforcement and voluntary ethanol consumption. Alcoholism, Clinical and Experimental Research. 25: 117S-126S. PMID 11391060 DOI: 10.1111/J.1530-0277.2001.Tb02385.X |
0.426 |
|
| 2001 |
Matsumoto I, Wilce PA, Buckley T, Dodd P, Puzke J, Spanagel R, Zieglgansberger W, Wolf G, Leng S, Rommelspacher H, Finckh U, Schmidt LG. Ethanol and gene expression in brain. Alcoholism, Clinical and Experimental Research. 25: 82S-86S. PMID 11391055 DOI: 10.1111/J.1530-0277.2001.Tb02379.X |
0.396 |
|
| 2001 |
Azad SC, Marsicano G, Eberlein I, Putzke J, Zieglgänsberger W, Spanagel R, Lutz B. Differential role of the nitric oxide pathway on delta(9)-THC-induced central nervous system effects in the mouse. The European Journal of Neuroscience. 13: 561-8. PMID 11168564 DOI: 10.1046/J.1460-9568.2001.01431.X |
0.31 |
|
| 2001 |
Schumann G, Rujescu D, Szegedi A, Singer P, Wiemann S, Klawe C, Anghelescu I, Giegling I, Wellek S, Heinz A, Spanagel R, Mann K, Henn FA, Dahmen N. Alcohol dependence is associated with a NMDA-receptor 2B gene variant American Journal of Medical Genetics - Neuropsychiatric Genetics. 105: 631. DOI: 10.1016/S0924-9338(02)80905-1 |
0.367 |
|
| 2000 |
Hölter SM, Henniger MS, Lipkowski AW, Spanagel R. Kappa-opioid receptors and relapse-like drinking in long-term ethanol-experienced rats. Psychopharmacology. 153: 93-102. PMID 11255932 DOI: 10.1007/S002130000601 |
0.376 |
|
| 2000 |
Spanagel R, Hölter SM. Pharmacological validation of a new animal model of alcoholism. Journal of Neural Transmission (Vienna, Austria : 1996). 107: 669-80. PMID 10943907 DOI: 10.1007/S007020070068 |
0.425 |
|
| 2000 |
Hölter SM, Linthorst AC, Reul JM, Spanagel R. Withdrawal symptoms in a long-term model of voluntary alcohol drinking in Wistar rats. Pharmacology, Biochemistry, and Behavior. 66: 143-51. PMID 10837854 DOI: 10.1016/S0091-3057(00)00196-9 |
0.397 |
|
| 1999 |
Spanagel R, Weiss F. The dopamine hypothesis of reward: past and current status. Trends in Neurosciences. 22: 521-7. PMID 10529820 DOI: 10.1016/S0166-2236(99)01447-2 |
0.35 |
|
| 1999 |
Winkler A, Mahal B, Kiianmaa K, Zieglgänsberger W, Spanagel R. Effects of chronic alcohol consumption on the expression of different NR1 splice variants in the brain of AA and ANA lines of rats. Brain Research. Molecular Brain Research. 72: 166-75. PMID 10529475 DOI: 10.1016/S0169-328X(99)00218-1 |
0.39 |
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| 1999 |
Hölter SM, Spanagel R. Effects of opiate antagonist treatment on the alcohol deprivation effect in long-term ethanol-experienced rats. Psychopharmacology. 145: 360-9. PMID 10460312 DOI: 10.1007/S002130051069 |
0.358 |
|
| 1999 |
Spanagel R, Hölter SM. Long-term alcohol self-administration with repeated alcohol deprivation phases: an animal model of alcoholism? Alcohol and Alcoholism (Oxford, Oxfordshire). 34: 231-43. PMID 10344783 DOI: 10.1093/Alcalc/34.2.231 |
0.412 |
|
| 1999 |
Winkler A, Mahal B, Zieglgänsberger W, Spanagel R. Accurate quantification of the mRNA of NMDAR1 splice variants measured by competitive RT-PCR. Brain Research. Brain Research Protocols. 4: 69-81. PMID 10234454 DOI: 10.1016/S1385-299X(99)00005-7 |
0.303 |
|
| 1999 |
Spanagel R. NEW ALCOHOL ANTICRAVING COMPOUNDS Behavioural Pharmacology. 10: S87. DOI: 10.1097/00008877-199908001-00221 |
0.336 |
|
| 1998 |
Spanagel R, Kirschke C, Tretter F, Holsboer F. Forced opiate withdrawal under anaesthesia augments and prolongs the occurrence of withdrawal signs in rats. Drug and Alcohol Dependence. 52: 251-6. PMID 9839151 DOI: 10.1016/S0376-8716(98)00106-9 |
0.311 |
|
| 1998 |
Putzke J, De Beun R, Schreiber R, De Vry J, Tölle TR, Zieglgänsberger W, Spanagel R. Long-term alcohol self-administration and alcohol withdrawal differentially modulate microtubule-associated protein 2 (MAP2) gene expression in the rat brain. Brain Research. Molecular Brain Research. 62: 196-205. PMID 9813323 DOI: 10.1016/S0169-328X(98)00253-8 |
0.418 |
|
| 1998 |
Spanagel R, Sillaber I, Zieglgänsberger W, Corrigall WA, Stewart J, Shaham Y. Acamprosate suppresses the expression of morphine-induced sensitization in rats but does not affect heroin self-administration or relapse induced by heroin or stress. Psychopharmacology. 139: 391-401. PMID 9809860 DOI: 10.1007/S002130050730 |
0.388 |
|
| 1998 |
Azzi M, Betancur C, Sillaber I, Spanagel R, Rostène W, Bérod A. Repeated administration of the neurotensin receptor antagonist SR 48692 differentially regulates mesocortical and mesolimbic dopaminergic systems. Journal of Neurochemistry. 71: 1158-67. PMID 9721741 DOI: 10.1046/J.1471-4159.1998.71031158.X |
0.338 |
|
| 1998 |
Winkler A, Spanagel R. Differences in the kappa opioid receptor mRNA content in distinct brain regions of two inbred mice strains. Neuroreport. 9: 1459-64. PMID 9631448 DOI: 10.1097/00001756-199805110-00039 |
0.313 |
|
| 1998 |
Darstein M, Albrecht C, López-Francos L, Knörle R, Hölter SM, Spanagel R, Feuerstein TJ. Release and accumulation of neurotransmitters in the rat brain: acute effects of ethanol in vitro and effects of long-term voluntary ethanol intake. Alcoholism, Clinical and Experimental Research. 22: 704-9. PMID 9622453 DOI: 10.1111/J.1530-0277.1998.Tb04314.X |
0.322 |
|
| 1998 |
Sillaber I, Montkowski A, Landgraf R, Barden N, Holsboer F, Spanagel R. Enhanced morphine-induced behavioural effects and dopamine release in the nucleus accumbens in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: influence of long-term treatment with the antidepressant moclobemide. Neuroscience. 85: 415-25. PMID 9622241 DOI: 10.1016/S0306-4522(97)00607-6 |
0.348 |
|
| 1998 |
Timpl P, Spanagel R, Sillaber I, Kresse A, Reul JM, Stalla GK, Blanquet V, Steckler T, Holsboer F, Wurst W. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nature Genetics. 19: 162-6. PMID 9620773 DOI: 10.1038/520 |
0.361 |
|
| 1998 |
Hundt W, Danysz W, Hölter SM, Spanagel R. Ethanol and N-methyl-D-aspartate receptor complex interactions: a detailed drug discrimination study in the rat. Psychopharmacology. 135: 44-51. PMID 9489933 DOI: 10.1007/S002130050484 |
0.327 |
|
| 1998 |
Sillaber I, Timpl P, Wurst W, Holsboer F, Spanagel R. ALCOHOL DRINKING AND WITHDRAWAL IN MICE LACKING A FUNCTIONAL CRH RECEPTOR 1 Behavioural Pharmacology. 9: S82. DOI: 10.1097/00008877-199808000-00191 |
0.408 |
|
| 1997 |
Hölter SM, Landgraf R, Zieglgänsberger W, Spanagel R. Time course of acamprosate action on operant ethanol self-administration after ethanol deprivation. Alcoholism, Clinical and Experimental Research. 21: 862-8. PMID 9267536 DOI: 10.1111/J.1530-0277.1997.Tb03850.X |
0.335 |
|
| 1997 |
Spanagel R, Zieglgänsberger W. Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes. Trends in Pharmacological Sciences. 18: 54-9. PMID 9090311 DOI: 10.1016/S0165-6147(97)89800-8 |
0.407 |
|
| 1997 |
Skutella T, Schwarting RK, Huston JP, Sillaber I, Probst JC, Holsboer F, Spanagel R. Infusions of tyrosine hydroxylase antisense oligodeoxynucleotide into substantia nigra of the rat: effects on tyrosine hydroxylase mRNA and protein content, striatal dopamine release and behaviour. The European Journal of Neuroscience. 9: 210-20. PMID 9058042 DOI: 10.1111/J.1460-9568.1997.Tb01392.X |
0.319 |
|
| 1996 |
Putzke J, Spanagel R, Tölle TR, Zieglgänsberger W. The anti-craving drug acamprosate reduces c-fos expression in rats undergoing ethanol withdrawal. European Journal of Pharmacology. 317: 39-48. PMID 8982717 DOI: 10.1016/S0014-2999(96)00696-6 |
0.348 |
|
| 1996 |
Hölter SM, Danysz W, Spanagel R. Evidence for alcohol anti-craving properties of memantine. European Journal of Pharmacology. 314: R1-2. PMID 8957265 DOI: 10.1016/S0014-2999(96)00670-X |
0.418 |
|
| 1996 |
Spanagel R. The influence of opioid antagonists on the discriminative stimulus effects of ethanol. Pharmacology, Biochemistry, and Behavior. 54: 645-9. PMID 8853184 DOI: 10.1016/0091-3057(95)02288-0 |
0.321 |
|
| 1996 |
Spanagel R, Zieglgänsberger W, Hundt W. Acamprosate and alcohol: III. Effects on alcohol discrimination in the rat. European Journal of Pharmacology. 305: 51-6. PMID 8813531 DOI: 10.1016/0014-2999(96)00176-8 |
0.354 |
|
| 1996 |
Spanagel R, Putzke J, Stefferl A, Schöbitz B, Zieglgänsberger W. Acamprosate and alcohol: II. Effects on alcohol withdrawal in the rat. European Journal of Pharmacology. 305: 45-50. PMID 8813530 DOI: 10.1016/0014-2999(96)00175-6 |
0.408 |
|
| 1996 |
Spanagel R, Hölter SM, Allingham K, Landgraf R, Zieglgänsberger W. Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat. European Journal of Pharmacology. 305: 39-44. PMID 8813529 DOI: 10.1016/0014-2999(96)00174-4 |
0.402 |
|
| 1995 |
Spanagel R, Montkowski A, Allingham K, Stöhr T, Shoaib M, Holsboer F, Landgraf R. Anxiety: a potential predictor of vulnerability to the initiation of ethanol self-administration in rats. Psychopharmacology. 122: 369-73. PMID 8657835 DOI: 10.1007/Bf02246268 |
0.34 |
|
| 1995 |
Spanagel R. Modulation of drug-induced sensitization processes by endogenous opioid systems. Behavioural Brain Research. 70: 37-49. PMID 8519427 DOI: 10.1016/0166-4328(94)00176-G |
0.353 |
|
| 1995 |
Shoaib M, Spanagel R, Stohr T, Shippenberg TS. Strain differences in the rewarding and dopamine-releasing effects of morphine in rats. Psychopharmacology. 117: 240-7. PMID 7753973 DOI: 10.1007/Bf02245193 |
0.331 |
|
| 1994 |
Shoaib M, Spanagel R. Mesolimbic sites mediate the discriminative stimulus effects of morphine. European Journal of Pharmacology. 252: 69-75. PMID 8149996 DOI: 10.1016/0014-2999(94)90576-2 |
0.325 |
|
| 1994 |
Skutella T, Probst JC, Jirikowski GF, Holsboer F, Spanagel R. Ventral tegmental area (VTA) injections of tyrosine hydroxylase phosphorothioate antisense oligonucleotide suppress operant behavior in rats. Neuroscience Letters. 167: 55-8. PMID 7909932 DOI: 10.1016/0304-3940(94)91026-X |
0.303 |
|
| 1994 |
Spanagel R, Shoaib M. Involvement of mesolimbic kappa-opioid systems in the discriminative stimulus effects of morphine. Neuroscience. 63: 797-804. PMID 7898679 DOI: 10.1016/0306-4522(94)90524-X |
0.31 |
|
| 1994 |
Spanagel R, Almeida OF, Bartl C, Shippenberg TS. Endogenous kappa-opioid systems in opiate withdrawal: role in aversion and accompanying changes in mesolimbic dopamine release. Psychopharmacology. 115: 121-7. PMID 7862883 DOI: 10.1007/Bf02244761 |
0.331 |
|
| 1994 |
Spanagel R, Eilbacher B, Wilke R. Memantine-induced dopamine release in the prefrontal cortex and striatum of the rat--a pharmacokinetic microdialysis study. European Journal of Pharmacology. 262: 21-6. PMID 7813574 DOI: 10.1016/0014-2999(94)90023-X |
0.304 |
|
| 1993 |
Spanagel R, Shippenberg TS. Modulation of morphine-induced sensitization by endogenous kappa opioid systems in the rat. Neuroscience Letters. 153: 232-6. PMID 8392157 DOI: 10.1016/0304-3940(93)90329-J |
0.303 |
|
| 1992 |
Spanagel R, Herz A, Shippenberg TS. Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proceedings of the National Academy of Sciences of the United States of America. 89: 2046-50. PMID 1347943 DOI: 10.1073/Pnas.89.6.2046 |
0.328 |
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