Chiatogu Onyewu, Ph.D.

Affiliations: 
2007 Duke University, Durham, NC 
Area:
Sex in Fungi, Signaling, Pathogenesis, Cryptococcus,
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"Chiatogu Onyewu"

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Joseph Heitman grad student 2007 Regeneron
 (Harnessing the calcineurin pathway for the development of novel antifungal drug interventions against Candida species.)
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Publications

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Onyewu C, Eads E, Schell WA, et al. (2007) Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model. Antimicrobial Agents and Chemotherapy. 51: 3743-6
Onyewu C, Heitman J. (2007) Unique applications of novel antifungal drug combinations Anti-Infective Agents in Medicinal Chemistry. 6: 3-15
Onyewu C, Afshari NA, Heitman J. (2006) Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy. Antimicrobial Agents and Chemotherapy. 50: 3963-5
Onyewu C, Wormley FL, Perfect JR, et al. (2004) The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans. Infection and Immunity. 72: 7330-3
Steinbach WJ, Schell WA, Blankenship JR, et al. (2004) In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy. 48: 1664-9
Onyewu C, Blankenship JR, Del Poeta M, et al. (2003) Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei. Antimicrobial Agents and Chemotherapy. 47: 956-64
Xu J, Onyewu C, Yoell HJ, et al. (2001) Dynamic and heterogeneous mutations to fluconazole resistance in Cryptococcus neoformans. Antimicrobial Agents and Chemotherapy. 45: 420-7
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