Cindy Hodakoski, Ph.D.

Affiliations: 
2012 Cellular, Molecular and Biomedical Studies Columbia University, New York, NY 
Area:
Molecular Biology, Biochemistry
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"Cindy Hodakoski"
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Ramon E. Parsons grad student 2012 Columbia
 (P-REX2 PH Domain Inhibition of PTEN Regulates Transformation, Insulin Signaling, and Glucose Homeostasis.)
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Publications

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Wang DG, Paddock MN, Lundquist MR, et al. (2019) PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism. Cell Reports. 27: 1991-2001.e5
Hodakoski C, Hopkins BD, Zhang G, et al. (2019) Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer. Cancers. 11
Hopkins BD, Pauli C, Du X, et al. (2018) Suppression of insulin feedback enhances the efficacy of PI3K inhibitors. Nature
Barrows D, Schoenfeld SM, Hodakoski C, et al. (2015) PAK kinases mediate the phosphorylation of PREX2 to initiate feedback inhibition of Rac1. The Journal of Biological Chemistry
Mense SM, Barrows D, Hodakoski C, et al. (2015) PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion. Science Signaling. 8: ra32
Hodakoski C, Fine B, Hopkins B, et al. (2015) Analysis of intracellular PTEN signaling and secretion. Methods (San Diego, Calif.). 77: 164-71
Hopkins BD, Hodakoski C, Barrows D, et al. (2014) PTEN function: the long and the short of it. Trends in Biochemical Sciences. 39: 183-90
Hodakoski C, Hopkins BD, Barrows D, et al. (2014) Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 111: 155-60
Hopkins BD, Fine B, Steinbach N, et al. (2013) A secreted PTEN phosphatase that enters cells to alter signaling and survival. Science (New York, N.Y.). 341: 399-402
Keniry M, Pires MM, Mense S, et al. (2013) Survival factor NFIL3 restricts FOXO-induced gene expression in cancer. Genes & Development. 27: 916-27
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