Linyuan Wang, Ph.D.

Affiliations: 
2012 Medical Biophysics University of Toronto, Toronto, ON, Canada 
Area:
Genetics, Cell Biology, Neuroscience Biology
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"Linyuan Wang"
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Minna Woo grad student 2012 University of Toronto
 (The Role of PTEN in Pancreatic Beta Cells and Insulin Promoter-expressing Neurons in Modulating Glucose Metabolism and Energy Homeostasis.)
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Publications

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Wang L, Luk CT, Cai EP, et al. (2015) PTEN deletion in pancreatic α-cells protects against high-fat diet-induced hyperglucagonemia and insulin resistance. Diabetes. 64: 147-57
Wang L, Luk CT, Schroer SA, et al. (2014) Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions. Diabetologia. 57: 1889-98
Wang L, Opland D, Tsai S, et al. (2014) Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex. Nature Medicine. 20: 484-92
Choi D, Cai EP, Schroer SA, et al. (2011) Vhl is required for normal pancreatic β cell function and the maintenance of β cell mass with age in mice. Laboratory Investigation; a Journal of Technical Methods and Pathology. 91: 527-38
Choi D, Schroer SA, Lu SY, et al. (2010) Erythropoietin protects against diabetes through direct effects on pancreatic beta cells. The Journal of Experimental Medicine. 207: 2831-42
Wang L, Liu Y, Yan Lu S, et al. (2010) Deletion of Pten in pancreatic ß-cells protects against deficient ß-cell mass and function in mouse models of type 2 diabetes. Diabetes. 59: 3117-26
Wu X, Wang L, Schroer S, et al. (2009) Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice. Diabetologia. 52: 2130-41
Radziszewska A, Schroer SA, Choi D, et al. (2009) Absence of caspase-3 protects pancreatic {beta}-cells from c-Myc-induced apoptosis without leading to tumor formation. The Journal of Biological Chemistry. 284: 10947-56
Radziszewska A, Choi D, Nguyen KT, et al. (2009) PTEN deletion and concomitant c-Myc activation do not lead to tumor formation in pancreatic beta cells. The Journal of Biological Chemistry. 284: 2917-22
Choi D, Nguyen KT, Wang L, et al. (2008) Partial deletion of Pten in the hypothalamus leads to growth defects that cannot be rescued by exogenous growth hormone. Endocrinology. 149: 4382-6
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