Megan E. Nelles, Ph.D.

Affiliations: 
2012 Medical Biophysics University of Toronto, Toronto, ON, Canada 
Area:
Immunology, Oncology, Medical Biophysics
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Parents

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Christopher J. Piage grad student 2012 University of Toronto
 (Characterization of an IL-12-driven anticancer response, and the CD4+ CTL population incited, in a murine model of leukaemia.)
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Publications

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Nguyen LT, Saibil SD, Sotov V, et al. (2019) Phase II clinical trial of adoptive cell therapy for patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and low-dose interleukin-2. Cancer Immunology, Immunotherapy : Cii
Butler MO, Saibil S, Bonilla L, et al. (2019) Effect of minimal lymphodepletion prior to ACT with TBI-1301, NY-ESO-1 specific gene-engineered TCR-T cells, on clinical responses and CRS. Journal of Clinical Oncology. 37: 2537-2537
Butler MO, Sotov V, Saibil S, et al. (2019) Adoptive T cell therapy with TBI-1301 results in gene-engineered T cell persistence and anti-tumour responses in patients with NY-ESO-1 expressing solid tumours Annals of Oncology. 30
Butler MO, Majeed H, Nelles M, et al. (2018) Study of TBI-1301 (NY-ESO-1 specific TCR gene transduced autologous T lymphocytes) in patients with solid tumors. Annals of Oncology : Official Journal of the European Society For Medical Oncology. 29: viii441
Moreau JM, Berger A, Nelles ME, et al. (2015) Inflammation rapidly reorganizes mouse bone marrow B cells and their environment in conjunction with early IgM responses. Blood. 126: 1184-92
Nelles ME, Paige CJ. (2015) CD4(+) T cell plasticity engenders robust immunity in response to cytokine therapy. Oncoimmunology. 4: e994370
Au BC, Liu Y, Huang J, et al. (2015) 413. Pre-Clinical Preparation and Validation of Tumor Cell-Based IL-12 Immunotherapy for Acute Myeloid Leukemia Molecular Therapy. 23: S163
Nelles ME, Moreau JM, Furlonger CL, et al. (2014) Murine splenic CD4⁺ T cells, induced by innate immune cell interactions and secreted factors, develop antileukemia cytotoxicity. Cancer Immunology Research. 2: 1113-24
Labbe A, Nelles M, Walia J, et al. (2009) IL-12 immunotherapy of murine leukaemia: comparison of systemic versus gene modified cell therapy. Journal of Cellular and Molecular Medicine. 13: 1962-76
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