Joe Bentz
Affiliations: | Drexel University, Philadelphia, PA, United States |
Area:
General Biophysics, Biochemistry, Molecular BiologyWebsite:
http://drexel.edu/coas/faculty-research/faculty-directory/bentz-joseph/Google:
"Joe Bentz"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Shlomo Nir | grad student | 1979 | SUNY Buffalo (Chemistry Tree) | |
| (On the analysis of aggregation of acidic phospholipid vesicles with regard to cation environment, temperature and their free energy of interaction.) | ||||
Children
Sign in to add trainee| Aditya Mittal | grad student | 2002 | Drexel |
| Poulomi Acharya | grad student | 2007 | Drexel |
| Annie A. Lumen | grad student | 2011 | Drexel |
BETA: Related publications
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Publications
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| Bentz J, Ellens H. (2021) Case Study 8: Status of the Structural Mass Action Kinetic Model of P-gp-Mediated Transport Through Confluent Cell Monolayers. Methods in Molecular Biology (Clifton, N.J.). 2342: 737-763 |
| Ellens H, Meng Z, Le Marchand SJ, et al. (2018) Mechanistic kinetic modeling generates system-independent P-glycoprotein mediated transport elementary rate constants for inhibition and, in combination with 3D SIM microscopy, elucidates the importance of microvilli morphology on P-glycoprotein mediated efflux activity. Expert Opinion On Drug Metabolism & Toxicology |
| Chaudhry A, Chung G, Lynn A, et al. (2018) Derivation of a system-independent Ki for Pgp-mediated digoxin transport from system-dependent IC50 data by accounting for the contribution of additional digoxin transporters. Drug Metabolism and Disposition: the Biological Fate of Chemicals |
| Meng Z, Ellens H, Bentz J. (2016) Extrapolation of elementary rate constants of P-glycoprotein mediated transport from MDCKII-hMDR1 to Caco-2 cells. Drug Metabolism and Disposition: the Biological Fate of Chemicals |
| Meng Z, Le Marchand S, Agnani D, et al. (2016) Microvilli morphology can affect efflux active P-glycoprotein in confluent MDCKII-NKI_hMDR1 and Caco-2 cell monolayers. Drug Metabolism and Disposition: the Biological Fate of Chemicals |
| O'Connor M, Lee C, Ellens H, et al. (2015) A novel application of t-statistics to objectively assess the quality of IC50 fits for P-glycoprotein and other transporters. Pharmacology Research & Perspectives. 3: e00078 |
| Bentz J, Ellens H. (2014) A structural model for the mass action kinetic analysis of P-gp mediated transport through confluent cell monolayers. Methods in Molecular Biology (Clifton, N.J.). 1113: 289-316 |
| Lumen AA, Li L, Li J, et al. (2013) Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp. Plos One. 8: e69394 |
| Zamek-Gliszczynski MJ, Lee CA, Poirier A, et al. (2013) ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans. Clinical Pharmacology and Therapeutics. 94: 64-79 |
| Bentz J. (2013) The IC50 for Inhibition of Digoxin Transport Across Confluent Cell Monolayers of P-gp Expressing Cell Lines is Often a Function of Inhibitor Binding to Both P-gp and an Unidentified Basolateral Digoxin Uptake Transporter Biophysical Journal. 104: 110a-111a |