Daniel R. Zakhary, Ph.D.

Affiliations: 
2000 Case Western Reserve University School of Medicine, Cleveland, OH, United States 
Area:
Medical Biophysics, Molecular Biology
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Meredith Bond grad student 2000 Case Western Medical School
 (beta-adrenergic pathway and PKA targeting in human dilated cardiomyopathy.)
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Publications

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Sprung J, Ogletree-Hughes ML, McConnell BK, et al. (2001) The effects of propofol on the contractility of failing and nonfailing human heart muscles. Anesthesia and Analgesia. 93: 550-9
Fink MA, Zakhary DR, Mackey JA, et al. (2001) AKAP-mediated targeting of protein kinase a regulates contractility in cardiac myocytes. Circulation Research. 88: 291-7
Zakhary DR, Fink MA, Ruehr ML, et al. (2000) Selectivity and regulation of A-kinase anchoring proteins in the heart. The role of autophosphorylation of the type II regulatory subunit of cAMP-dependent protein kinase. The Journal of Biological Chemistry. 275: 41389-95
Zakhary DR, Moravec CS, Bond M. (2000) Regulation of PKA binding to AKAPs in the heart: alterations in human heart failure. Circulation. 101: 1459-64
Ruehr ML, Zakhary DR, Damron DS, et al. (1999) Cyclic AMP-dependent protein kinase binding to A-kinase anchoring proteins in living cells by fluorescence resonance energy transfer of green fluorescent protein fusion proteins. The Journal of Biological Chemistry. 274: 33092-6
Zakhary DR, Moravec CS, Stewart RW, et al. (1999) Protein kinase A (PKA)-dependent troponin-I phosphorylation and PKA regulatory subunits are decreased in human dilated cardiomyopathy. Circulation. 99: 505-10
Kanaya N, Zakhary DR, Murray PA, et al. (1998) Differential effects of fentanyl and morphine on intracellular Ca2+ transients and contraction in rat ventricular myocytes. Anesthesiology. 89: 1532-42
Kanaya N, Zakhary DR, Murray PA, et al. (1998) Thiopental alters contraction, intracellular Ca2+, and pH in rat ventricular myocytes. Anesthesiology. 89: 202-14
Zakhary DR, Kanaya N, Murray PA, et al. (1998) PROPOFOL INHIBITS Ca2+ UPTAKE INTO ISOLATED SARCOPLASMIC RETICULUM VESICLES FROM RAT CARDIOMYOCYTES Anesthesiology. 89: 591A
Moravec CS, Zakhary D, Darvish A, et al. (1997) A280 PROPOFOL INHIBITS Ca sup 2+ UPTAKE BY THE HUMAN CARDIAC SARCOPLASMIC RETICULUM Anesthesiology. 87: 280A
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