Brian M. Button, Ph.D.

Affiliations: 
2000 University of Texas Medical Branch, Galveston, TX 
Area:
Animal Physiology Biology, Medical Biophysics, Molecular Biology
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Luis Reuss grad student 2000 UTMB (Physiology Academic Tree)
 (Molecular basis of the activation of human and Xenopus CFTR by PKA- and PKC-mediated phosphorylation.)
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Publications

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Mikami Y, Grubb BR, Rogers TD, et al. (2023) Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration. Science Translational Medicine. 15: eabo7728
Kato T, Radicioni G, Papanikolas MJ, et al. (2022) Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis. Science Advances. 8: eabm9718
Hill DB, Button B, Rubinstein M, et al. (2022) Physiology and Pathophysiology of Human Airway Mucus. Physiological Reviews
van Heusden C, Grubb BR, Button B, et al. (2021) Airway Epithelial Nucleotide Release Contributes to Mucociliary Clearance. Life (Basel, Switzerland). 11
Bennett WD, Henderson AG, Ceppe A, et al. (2020) Effect of hypertonic saline on mucociliary clearance and clinical outcomes in chronic bronchitis. Erj Open Research. 6
Danahay HL, Lilley S, Fox R, et al. (2020) TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis. American Journal of Respiratory and Critical Care Medicine
van Heusden C, Button B, Anderson WH, et al. (2019) Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia. American Journal of Physiology. Lung Cellular and Molecular Physiology
Ramsey KA, Chen ACH, Radicioni G, et al. (2019) Airway Mucus Hyperconcentration in Non-Cystic Fibrosis Bronchiectasis. American Journal of Respiratory and Critical Care Medicine
Chen G, Sun L, Kato T, et al. (2019) IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis. The Journal of Clinical Investigation
Brinks V, Lipinska K, de Jager M, et al. (2019) The Cystic Fibrosis-Like Airway Surface Layer Is not a Significant Barrier for Delivery of Eluforsen to Airway Epithelial Cells. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 32: 303-316
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