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Grant E. Blouse, Ph.D.

Affiliations: 
2003 Wayne State University, Detroit, MI, United States 
Area:
Biochemistry, Molecular Biology, General Biophysics
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Joseph D. Shore grad student 2003 Wayne State
 (Protein engineering of plasminogen activator inhibitor-1 provides new insights into the inhibition mechanism of serpins.)

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Publications

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Kristensen LH, Olsen OH, Blouse GE, et al. (2016) Releasing the brakes in coagulation Factor IXa by cooperative maturation of the substrate binding site. The Biochemical Journal
Botkjaer KA, Fogh S, Bekes EC, et al. (2011) Targeting the autolysis loop of urokinase-type plasminogen activator with conformation-specific monoclonal antibodies. The Biochemical Journal. 438: 39-51
Bøtkjaer KA, Byszuk AA, Andersen LM, et al. (2009) Nonproteolytic induction of catalytic activity into the single-chain form of urokinase-type plasminogen activator by dipeptides. Biochemistry. 48: 9606-17
Dupont DM, Madsen JB, Kristensen T, et al. (2009) Biochemical properties of plasminogen activator inhibitor-1. Frontiers in Bioscience. 14: 1337-1361
Blouse GE, Dupont DM, Schar CR, et al. (2009) Interactions of plasminogen activator inhibitor-1 with vitronectin involve an extensive binding surface and induce mutual conformational rearrangements. Biochemistry. 48: 1723-35
Blouse GE, Bøtkjaer KA, Deryugina E, et al. (2009) A novel mode of intervention with serine protease activity: targeting zymogen activation. The Journal of Biological Chemistry. 284: 4647-57
Schar CR, Jensen JK, Christensen A, et al. (2008) Characterization of a site on PAI-1 that binds to vitronectin outside of the somatomedin B domain. The Journal of Biological Chemistry. 283: 28487-96
Mathiasen L, Dupont DM, Christensen A, et al. (2008) A peptide accelerating the conversion of plasminogen activator inhibitor-1 to an inactive latent state. Molecular Pharmacology. 74: 641-53
Schar CR, Blouse GE, Minor KH, et al. (2008) A deletion mutant of vitronectin lacking the somatomedin B domain exhibits residual plasminogen activator inhibitor-1-binding activity. The Journal of Biological Chemistry. 283: 10297-309
Dupont DM, Blouse GE, Hansen M, et al. (2006) Evidence for a pre-latent form of the serpin plasminogen activator inhibitor-1 with a detached beta-strand 1C. The Journal of Biological Chemistry. 281: 36071-81
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