Cole M. Haynes, Ph.D.

Affiliations: 
2003 University of Missouri - Kansas City, USA 
Area:
Cell Biology, General Biophysics
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Antony A. Cooper grad student 2003 University of Missouri - Kansas City
 (Degradation of misfolded proteins from the endoplasmic reticulum: Identification of a novel mechanism and prevention of cell death.)
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Publications

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Dai CY, Ng CC, Hung GCC, et al. (2023) ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription. Nature Cell Biology
Uma Naresh N, Kim S, Shpilka T, et al. (2022) Mitochondrial genome recovery by ATFS-1 is essential for development after starvation. Cell Reports. 41: 111875
Haynes CM, Hekimi S. (2022) Mitochondrial dysfunction, aging, and the mitochondrial unfolded protein response in Caenorhabditis elegans. Genetics
Statzer C, Meng J, Venz R, et al. (2022) ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1. Nature Communications. 13: 967
Yang Q, Liu P, Anderson NS, et al. (2022) LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria. Nature Cell Biology. 24: 181-193
Shpilka T, Du Y, Yang Q, et al. (2021) UPR scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans. Nature Communications. 12: 479
Ali L, Haynes CM. (2020) Mitochondrial translation, dynamics, and lysosomes combine to extend lifespan. The Journal of Cell Biology. 219
Anderson NS, Haynes CM. (2020) Folding the Mitochondrial UPR into the Integrated Stress Response. Trends in Cell Biology. 30: 428-439
Milstone ZJ, Saheera S, Bourke LM, et al. (2020) Histone deacetylases 1 and 2 silence cryptic transcription to promote mitochondrial function during cardiogenesis. Science Advances. 6: eaax5150
Tremblay BP, Haynes CM. (2020) Mitochondrial distress call moves to the cytosol to trigger a response to stress. Nature. 579: 348-349
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